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Wound Repair and Antimicrobial Peptides

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Antimicrobial Peptides and Innate Immunity

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Wounding of protective barriers is a major insult to the organism and immediately sets in motion a complex cascade of cellular responses in order to re-establish tissue integrity. Antimicrobial proteins, AMPs, are important components in the innate immune system and play a vital role in this process. The defensin family of proteins and the human cathelicidin, hCAP18, are the most documented AMPs in human and the focus of this review. Still, many proteins display antimicrobial activity, suggesting that the capacity to defend against microbes has been a driving force during evolution. In addition to direct killing of microbes, AMPs are involved in the inflammatory reaction through chemotaxis and control of cytokine response. Furthermore, recent data also show that AMPs have growth-factor like effects and signal via receptors promoting angiogenesis and re-epithelialization. Thus, the role of AMPs in wound healing is only beginning to be understood and may be far-reaching.

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Abbreviations

AMP:

Antimicrobial protein

EGFR:

Epidermal growth factor receptor

FPRL1:

Formyl peptide receptor-like 1

LPS:

Lipopolysaccharide

LTA:

Lipoteichoic acid

MAPK:

Mitogen activated kinases

P2X7:

Purinergic receptor

PI3K:

Phosphoinositide 3-kinase

PDC:

Plasmocytoid dendritic cell

SLPI:

Secretory leukocyte protease inhibitor

TLR:

Toll-like receptor

TGF-β:

Transforming growth factor beta

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Authors and Affiliations

  1. Unit of Dermatology and Venereology, Karolinska Institutet, Stockholm, Sweden

    Mona Ståhle

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  1. Mona Ståhle
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  1. , Department of Pulmonology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2300 RC, Netherlands

    Pieter S. Hiemstra

  2. Ctr for Infection & Immun. Amsterdam, Dept. Medical Microbiology, University of Amsterdam, Meibergdreef 15, Amsterdam, 1105 AZ, Netherlands

    Sebastian A. J. Zaat

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Ståhle, M. (2013). Wound Repair and Antimicrobial Peptides. In: Hiemstra, P., Zaat, S. (eds) Antimicrobial Peptides and Innate Immunity. Progress in Inflammation Research. Springer, Basel. https://doi.org/10.1007/978-3-0348-0541-4_5

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