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Matrix Metalloproteinase Inhibitors as New Anti-inflammatory Drugs

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Proteases and Their Receptors in Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Matrix metalloproteinases (MMPs) are a group of proteases known to regulate the turnover of extracellular matrix (ECM) and thus are suggested to be important in the process of several diseases associated with tissue remodeling and inflammation. Degradation of ECM is currently associated with structural and recruited cell activation and release of inflammatory mediators and MMPs. Indeed, a marked increase in their expression is observed associated with a variety of inflammatory diseases. In these conditions, we have to consider MMPs as therapeutic targets which can be inhibited by nonselective and/or selective inhibitors as anti-inflammatory compounds. The present review aims to discuss the potential interest of selective and nonselective MMP inhibitors in several inflammatory diseases including respiratory and cardiovascular pathologies, liver fibrosis, and arthritis. This chapter also includes a special part on macrophage metalloelastase (MMP-12) as a target for inflammatory respiratory diseases.

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Acknowledgements

The authors thank Florence Jacquet for the corrections of the manuscript.

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Authors and Affiliations

  1. INSERM UMR 991, Université de Rennes 1, 2 avenue du professeur Léon Bernard, 35043, Rennes cedex, France

    Vincent Lagente, Tatiana Victoni & Elisabeth Boichot

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  1. Vincent Lagente
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  2. Tatiana Victoni
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  3. Elisabeth Boichot
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Correspondence to Vincent Lagente .

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  1. CHU Purpan, INSERM U 563, BP 3028, Toulouse Cedex, 31024, France

    Nathalie Vergnolle

  2. Institut Pasteur, Unite de Defense Innee et Inflammation, INSERM U 874, Rue du Dr. Roux 25, Paris Cedex 15, 75724, France

    Michel Chignard

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Lagente, V., Victoni, T., Boichot, E. (2011). Matrix Metalloproteinase Inhibitors as New Anti-inflammatory Drugs. In: Vergnolle, N., Chignard, M. (eds) Proteases and Their Receptors in Inflammation. Progress in Inflammation Research. Springer, Basel. https://doi.org/10.1007/978-3-0348-0157-7_5

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