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The Role of Inflammasomes in Viral Infection

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The Inflammasomes

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

There are three known receptors capable of inducing inflammasome formation in response to viral infections: NLRP3, AIM2, and RIG-I. Here, we discuss the viruses and mechanisms of activation involved in inflammasome signaling. We also briefly discuss some of the viruses known to activate caspase-1 and induce secretion of IL-1β or IL-18, but for which the upstream inflammasome signaling pathway is not fully elucidated. Finally, the ability of several virus-encoded proteins to counteract inflammasome activation and their role in the pathogenesis of disease is reviewed.

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Acknowledgments

The authors’ own work is supported by NIH (AR056296), a Cancer Center Support Grant (CCSG 2 P30 CA 21765), Centers of Excellence for Influenza Research and Surveillance (CEIRS) project, and the American Lebanese Syrian Associated Charities (to T-D. K).

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Authors and Affiliations

  1. Department of Immunology, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, MS 351, Memphis, TN, 38105, USA

    Christopher R. Lupfer & Thirumala-Devi Kanneganti

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  1. Christopher R. Lupfer
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  2. Thirumala-Devi Kanneganti
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Correspondence to Thirumala-Devi Kanneganti .

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Editors and Affiliations

  1. Institut de Transgénose, Labo. d'Immunologie et, CNRS, rue de la Férollerie 3B, Orléans CX 2, 45071, France

    Isabelle Couillin

  2. CNRS UMR 5201, Labo. Génétique et Cancer, Université de Lyon I, rue Laënnec 28, Lyon, 69008, France

    Virginie Pétrilli

  3. Dept. Immunology & Infectious, Diseases, Harvard School of Public Health, Huntington Ave. 651, Boston, 02115-6017, Massachusetts, USA

    Fabio Martinon

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Lupfer, C.R., Kanneganti, TD. (2011). The Role of Inflammasomes in Viral Infection. In: Couillin, I., Pétrilli, V., Martinon, F. (eds) The Inflammasomes. Progress in Inflammation Research. Springer, Basel. https://doi.org/10.1007/978-3-0348-0148-5_4

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  • DOI: https://doi.org/10.1007/978-3-0348-0148-5_4

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