Abstract
We developed the first model simulator of leg movements activity during sleep. We designed and calibrated a phenomenological model on control subjects not showing significant periodic leg movements (PLM). To test a single generator hypothesis behind PLM—a single pacemaker possibly resulting from two (or more) interacting spinal/supraspinal generators—we added a periodic excitatory input to the control model. We describe the onset of a movement in one leg as the firing of a neuron integrating physiological excitatory and inhibitory inputs from the central nervous system, while the duration of the movement was drawn in accordance with statistical evidence. The period and the intensity of the periodic input were calibrated on a dataset of subjects showing PLM (mainly restless legs syndrome patients). Despite its many simplifying assumptions—the strongest being the stationarity of the neural processes during night sleep—the model simulations are in remarkable agreement with the polysomnographically recorded data.
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References
Ferri, R., et al.: World Association of Sleep Medicine (WASM) 2016 standards for recording and scoring leg movements in polysomnograms developed by a joint task force from the International and European Restless Legs Syndrome Study Groups (IRLSSG and EURLSSG). Sleep Med. 26, 86–95 (2016)
Pennestri, M.H., Whittom, S., Adam, B., Petit, D., Carrier, J., Montplaisir, J.: PLMS and PLMW in healthy subjects as a function of age: prevalence and interval distribution. Sleep 29(9), 1183–1187 (2006)
Ferri, R.: The time structure of leg movement activity during sleep: the theory behind the practice. Sleep Med. 13(4), 433–441 (2012)
American Academy of Sleep Medicine: International classification of sleep disorders (2014)
Ferri, R., Koo, B., Picchietti, D.L., Fulda, S.: Periodic leg movements during sleep: phenotype, neurophysiology, and clinical significance. Sleep Med. 31, 29–38 (2017)
Ferri, R., et al.: Neurophysiological correlates of sleep leg movements in acute spinal cord injury. Clin. Neurophysiol. 126(2), 333–338 (2015)
Salminen, V., et al.: Disconnection between periodic leg movements and cortical arousals in spinal cord injury. J. Clin. Sleep Med. 9(11), 1207–1209 (2013)
Figorilli, M., Puligheddu, M., Congiu, P., Ferri, R.: The clinical importance of periodic leg movements in sleep. Current Treat. Opt. Neurol. 19(3), 10 (2017)
Allen, R.P., et al.: Animal models of RLS phenotypes. Sleep Med. 31, 23–28 (2017)
Italia, M., Danani, A., Dercole, F., Ferri, R., Manconi, M.: A calibrated model with a single-generator simulating polysomnographically recorded periodic leg movements. J. Sleep Res. 31(5), e13567 (2022)
Stein, R.B.: A theoretical analysis of neuronal variability. Biophys. J. 5(2), 173–194 (1965)
Burkitt, A.N.: A review of the integrate-and-fire neuron model: I. Homogeneous synaptic input. Biol. Cybern. 95, 1–19 (2006)
Ferri, R., Zucconi, M., Manconi, M., Plazzi, G., Bruni, O., Ferini-Strambi, L.: New approaches to the study of periodic leg movements during sleep in restless legs syndrome. Sleep 29(6), 759–769 (2006)
Ferri, R., et al.: Putting the periodicity back into the periodic leg movement index: an alternative data-driven algorithm for the computation of this index during sleep and wakefulness. Sleep Med. 16, 1229–1235 (2015)
Ferri, R., et al.: Bilateral leg movements during sleep: detailing their structure and features in normal controls and in patients with restless legs syndrome. Sleep Med. 32, 10–15 (2017)
Gramacki, A.: Nonparametric Kernel Density Estimation and its Computational Aspects. Springer (2018)
Acknowledgements
The authors thank the valuable suggestions received by the many reviewers. We also appreciate all the participants of the International Conference on Computational Intelligence Methods for Bioinformatics and Biostatistics, CIBB 2021, for their constructive feedback.
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Italia, M., Danani, A., Dercole, F., Ferri, R., Manconi, M. (2022). The First in-silico Model of Leg Movement Activity During Sleep. In: Chicco, D., et al. Computational Intelligence Methods for Bioinformatics and Biostatistics. CIBB 2021. Lecture Notes in Computer Science(), vol 13483. Springer, Cham. https://doi.org/10.1007/978-3-031-20837-9_4
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