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Endovascular Reperfusion of Acute Large Vessel Occlusion Stroke

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Neurointervention in the Medical Specialties

Part of the book series: Current Clinical Neurology ((CCNEU))

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Abstract

Acute stroke treatment continues to evolve with optimization of systemic intravenous thrombolysis and endovascular mechanical thrombectomy (MT) for intracranial large vessel occlusion (LVO). Neurointerventional techniques to achieve reperfusion in acute LVO stroke initially involved local intra-arterial infusion of thrombolytic agents. The subsequent development of MT devices has resulted in more complete and faster arterial recanalization while maintaining patient safety. Today, MT is standard of care for LVO stroke up to 24 h from last known well. In this chapter, we discuss various endovascular recanalization techniques for LVO stroke with illustrative cases.

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References

  1. Nenci GG, Gresele P, Taramelli M, Agnelli G, Signorini E. Thrombolytic therapy for thromboembolism of vertebrobasilar artery. Angiology. 1983;34(9):561–71.

    CAS  PubMed  Google Scholar 

  2. Brückmann H, Ferbert A, del Zoppo GJ, Hacke W, Zeumer H. Acute vertebral-basilar thrombosis. Angiologic-clinical comparison and therapeutic implications. Acta Radiol Suppl. 1986;369:38–42.

    PubMed  Google Scholar 

  3. Hentschel KA, et al. Comparison of non-stent retriever and stent retriever mechanical thrombectomy devices for the endovascular treatment of acute ischemic stroke. J Neurosurg. 2017;126:1123–30.

    PubMed  Google Scholar 

  4. Goyal M, et al. Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet. 2016;387:1723–31.

    PubMed  Google Scholar 

  5. Albers GW, et al. Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging. N Engl J Med. 2018;378:708–18.

    PubMed  PubMed Central  Google Scholar 

  6. Nogueira RG, et al. Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct. N Engl J Med. 2018;378:11–21.

    PubMed  Google Scholar 

  7. Yang P, et al. Endovascular thrombectomy with or without intravenous alteplase in acute stroke. N Engl J Med. 2020;382:1981–93.

    CAS  PubMed  Google Scholar 

  8. Suzuki K, Kimura K, Takeuchi M, et al. The randomized study of endovascular therapy with versus without intravenous tissue plasminogen activator in acute stroke with ICA and M1 occlusion (SKIP study). Int J Stroke. 2019;14:752–5.

    PubMed  Google Scholar 

  9. Gariel F, et al. Mechanical thrombectomy outcomes with or without intravenous thrombolysis. Stroke. 2018;49:2383–90.

    PubMed  Google Scholar 

  10. Furlan A, Higashida R, Wechsler L, Gent M, Rowley H, Kase C, et al. Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in acute cerebral thromboembolism. JAMA. 1999;282(21):2003–11.

    CAS  PubMed  Google Scholar 

  11. Zaidat OO, Suarez JI, Santillan C, Sunshine JL, Tarr RW, Paras VH, et al. Response to intra-arterial and combined intravenous and intra-arterial thrombolytic therapy in patients with distal internal carotid artery occlusion. Stroke. 2002;33(7):1821–6.

    CAS  PubMed  Google Scholar 

  12. Lee KY, Kim DI, Kim SH, Lee SI, Chung HW, Shim YW, et al. Sequential combination of intravenous recombinant tissue plasminogen activator and intra-arterial urokinase in acute ischemic stroke. AJNR Am J Neuroradiol. 2004;25(9):1470–5.

    PubMed  PubMed Central  Google Scholar 

  13. Shaltoni HM, Albright KC, Gonzales NR, Weir RU, Khaja AM, Sugg RM, et al. Is intra-arterial thrombolysis safe after full-dose intravenous recombinant tissue plasminogen activator for acute ischemic stroke? Stroke. 2007;38(1):80–4.

    CAS  PubMed  Google Scholar 

  14. Misra V, El Khoury R, Arora R, Chen PR, Suzuki S, Harun N, et al. Safety of high doses of urokinase and reteplase for acute ischemic stroke. AJNR Am J Neuroradiol. 2011;32(6):998–1001.

    CAS  PubMed  PubMed Central  Google Scholar 

  15. Eckert B, Kucinski T, Neumaier-Probst E, Fiehler J, Röther J, Zeumer H. Local intra-arterial fibrinolysis in acute hemispheric stroke: effect of occlusion type and fibrinolytic agent on recanalization success and neurological outcome. Cerebrovasc Dis. 2003;15(4):258–63.

    CAS  PubMed  Google Scholar 

  16. Sugg RM, Noser EA, Shaltoni HM, Gonzales NR, Campbell MS, Weir R, et al. Intra-arterial reteplase compared to urokinase for thrombolytic recanalization in acute ischemic stroke. AJNR Am J Neuroradiol. 2006;27(4):769–73.

    CAS  PubMed  PubMed Central  Google Scholar 

  17. Qureshi AI, Siddiqui AM, Suri MF, Kim SH, Ali Z, Yahia AM, et al. Aggressive mechanical clot disruption and low-dose intra-arterial third-generation thrombolytic agent for ischemic stroke: a prospective study. Neurosurgery. 2002;51(5):1319–27. discussion 1327–9

    PubMed  Google Scholar 

  18. Yoon W, Park MS, Cho KH. Low-dose intra-arterial urokinase and aggressive mechanical clot disruption for acute ischemic stroke after failure of intravenous thrombolysis. AJNR Am J Neuroradiol. 2010;31(1):161–4.

    CAS  PubMed  PubMed Central  Google Scholar 

  19. Smith WS, Sung G, Starkman S, Saver JL, Kidwell CS, Gobin YP, et al. Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial. Stroke. 2005;36(7):1432–8.

    PubMed  Google Scholar 

  20. Smith WS, Sung G, Saver J, Budzik R, Duckwiler G, Liebeskind DS, et al. Mechanical thrombectomy for acute ischemic stroke: final results of the multi MERCI trial. Stroke. 2008;39(4):1205–12.

    PubMed  Google Scholar 

  21. Zhu L, Liebeskind DS, Jahan R, Starkman S, Salamon N, Duckwiler G, et al. Thrombus branching and vessel curvature are important determinants of middle cerebral artery trunk recanalization with Merci thrombectomy devices. Stroke. 2012;43(3):787–92.

    PubMed  PubMed Central  Google Scholar 

  22. Yuki I, Kan I, Vinters HV, Kim RH, Golshan A, Vinuela FA, et al. The impact of thromboemboli histology on the performance of a mechanical thrombectomy device. AJNR Am J Neuroradiol. 2012;33(4):643–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  23. Loh Y, Jahan R, McArthur DL, Shi ZS, Gonzalez NR, Duckwiler GR, et al. Recanalization rates decrease with increasing thrombectomy attempts. AJNR Am J Neuroradiol. 2010;31(5):935–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  24. Bose A, Henkes H, Alfke K, Reith W, Mayer TE, Berlis A, et al. The penumbra system: a mechanical device for the treatment of acute stroke due to thromboembolism. AJNR Am J Neuroradiol. 2008;29(7):1409–13.

    CAS  PubMed  PubMed Central  Google Scholar 

  25. Tarr R, et al. The POST trial: initial post-market experience of the Penumbra system: revascularization of large vessel occlusion in acute ischemic stroke in the United States and Europe. J Neurointerv Surg. 2018;10:i35–8.

    PubMed  Google Scholar 

  26. Penumbra Pivotal Stroke Trial Investigators. The penumbra pivotal stroke trial: safety and effectiveness of a new generation of mechanical devices for clot removal in intracranial large vessel occlusive disease. Stroke. 2009;40(8):2761–8.

    Google Scholar 

  27. Almekhlafi MA, Menon BK, Freiheit EA, Demchuk AM, Goyal M. A meta-analysis of observational intra-arterial stroke therapy studies using the merci device, penumbra system, and retrievable stents. AJNR Am J Neuroradiol. 2013;34(1):140–5.

    CAS  PubMed  PubMed Central  Google Scholar 

  28. Lapergue B, Blanc R, Gory B, et al. Effect of endovascular contact aspiration vs stent retriever on revascularization in patients with acute ischemic stroke and large vessel occlusion: the ASTER randomized clinical trial. JAMA. 2017;318:443–52.

    PubMed  PubMed Central  Google Scholar 

  29. Turk AS 3rd, Siddiqui A, Fifi JT, De Leacy RA, Fiorella DJ, Gu E, Levy EI, Snyder KV, Hanel RA, Aghaebrahim A, Woodward BK, Hixson HR, Chaudry MI, Spiotta AM, Rai AT, Frei D, Almandoz JED, Kelly M, Arthur A, Baxter B, English J, Linfante I, Fargen KM, Mocco J. Aspiration thrombectomy versus stent retriever thrombectomy as first-line approach for large vessel occlusion (COMPASS): a multicentre, randomised, open label, blinded outcome, non-inferiority trial. Lancet. 2019;393(10175):998–1008.

    PubMed  Google Scholar 

  30. Broussalis E, Trinka E, Hitzl W, Wallner A, Chroust V, Killer-Oberpfalzer M. Comparison of stent-retriever devices versus the merci retriever for endovascular treatment of acute stroke. AJNR Am J Neuroradiol. 2013;34(2):366–72.

    CAS  PubMed  PubMed Central  Google Scholar 

  31. Deng L, et al. Comparison of four food and drug administration-approved mechanical thrombectomy devices for acute ischemic stroke: a network meta-analysis. World Neurosurg. 2019;127:e49–57.

    PubMed  Google Scholar 

  32. Humphries W, et al. Distal aspiration with retrievable stent assisted thrombectomy for the treatment of acute ischemic stroke. J Neurointerv Surg. 2015;7:90–4.

    PubMed  Google Scholar 

  33. Saqqur M, Uchino K, Demchuk AM, Molina CA, Garami Z, Calleja S, et al. Site of arterial occlusion identified by transcranial Doppler predicts the response to intravenous thrombolysis for stroke. Stroke. 2007;38(3):948–54.

    PubMed  Google Scholar 

  34. Schonewille WJ, Algra A, Serena J, Molina C, Kappelle LJ. Outcome in patients with basilar artery occlusion treated conventionally. J Neurol Neurosurg Psychiatry. 2005;76(9):1238–41.

    CAS  PubMed  PubMed Central  Google Scholar 

  35. Hacke W, Zeumer H, Ferbert A, Brückmann H, del Zoppo GJ. Intra-arterial thrombolytic therapy improves outcome in patients with acute vertebrobasilar occlusive disease. Stroke. 1988;19(10):1216–22.

    CAS  PubMed  Google Scholar 

  36. Brandt T, von Kummer R, Müller-Küppers M, Hacke W. Thrombolytic therapy of acute basilar artery occlusion. Variables affecting recanalization and outcome. Stroke. 1996;27(5):875–81.

    CAS  PubMed  Google Scholar 

  37. Watson CCL, Feria A, Chen CJ, Camacho A. Outcomes and complications of endovascular mechanical thrombectomy in the treatment of acute posterior circulation occlusions: a systematic review. World Neurosurg. 2020;145:35–44.

    PubMed  Google Scholar 

  38. Arnold M, Nedeltchev K, Schroth G, Baumgartner RW, Remonda L, Loher TJ, et al. Clinical and radiological predictors of recanalisation and outcome of 40 patients with acute basilar artery occlusion treated with intra-arterial thrombolysis. J Neurol Neurosurg Psychiatry. 2004;75(6):857–62.

    CAS  PubMed  PubMed Central  Google Scholar 

  39. Styczen H, et al. Approaching the boundaries of endovascular treatment in acute ischemic stroke : multicenter experience with mechanical thrombectomy in vertebrobasilar artery branch occlusions. Clin Neuroradiol. 2020;31(3):791–8. https://doi.org/10.1007/s00062-020-00970-7.

    Article  PubMed  Google Scholar 

  40. Urbach H, Ries F, Ostertun B, Solymosi L. Local intra-arterial fibrinolysis in thromboembolic “T” occlusions of the internal carotid artery. Neuroradiology. 1997;39(2):105–10.

    CAS  PubMed  Google Scholar 

  41. Arnold M, Nedeltchev K, Mattle HP, Loher TJ, Stepper F, Schroth G, et al. Intra-arterial thrombolysis in 24 consecutive patients with internal carotid artery T occlusions. J Neurol Neurosurg Psychiatry. 2003;74(6):739–42.

    CAS  PubMed  PubMed Central  Google Scholar 

  42. Möhlenbruch M, Seifert M, Okulla T, Wüllner U, Hadizadeh DR, Nelles M, et al. Mechanical thrombectomy compared to local-intraarterial thrombolysis in carotid T and middle cerebral artery occlusions: a single center experience. Clin Neuroradiol. 2012;22(2):141–7.

    PubMed  Google Scholar 

  43. Rubiera M, Ribo M, Delgado-Mederos R, Santamarina E, Delgado P, Montaner J, et al. Tandem internal carotid artery/middle cerebral artery occlusion: an independent predictor of poor outcome after systemic thrombolysis. Stroke. 2006;37(9):2301–5.

    PubMed  Google Scholar 

  44. Ozdemir O, Bussière M, Leung A, Gulka I, Lee D, Chan R, et al. Intra-arterial thrombolysis of occluded middle cerebral artery by use of collateral pathways in patients with tandem cervical carotid artery/middle cerebral artery occlusion. AJNR Am J Neuroradiol. 2008;29(8):1596–600.

    CAS  PubMed  PubMed Central  Google Scholar 

  45. Malik AM, Vora NA, Lin R, Zaidi SF, Aleu A, Jankowitz BT, et al. Endovascular treatment of tandem extracranial/intracranial anterior circulation occlusions: preliminary single-center experience. Stroke. 2011;42(6):1653–7.

    PubMed  Google Scholar 

  46. Machi P, Lobotesis K, Maldonado IL, Costalat V, Vendrell JF, Riquelme C, et al. Endovascular treatment of tandem occlusions of the anterior cerebral circulation with solitaire FR thrombectomy system. Initial experience. Eur J Radiol. 2012;81(11):3479–84.

    PubMed  Google Scholar 

  47. Lavalleé PC, Mazighi M, Saint-Maurice JP, Meseguer E, Abboud H, Klein IF, et al. Stent-assisted endovascular thrombolysis versus intravenous thrombolysis in internal carotid artery dissection with tandem internal carotid and middle cerebral artery occlusion. Stroke. 2007;38(8):2270–4.

    PubMed  Google Scholar 

  48. Wilson MP, et al. Management of tandem occlusions in acute ischemic stroke - intracranial versus extracranial first and extracranial stenting versus angioplasty alone: a systematic review and meta-analysis. J Neurointerv Surg. 2018;10:721–8.

    PubMed  Google Scholar 

  49. Linfante I, Reddy AS, Andreone V, Caplan LR, Selim M, Hirsch JA. Intra-arterial thrombolysis in patients treated with warfarin. Cerebrovasc Dis. 2005;19(2):133–5.

    PubMed  Google Scholar 

  50. Janjua N, Alkawi A, Georgiadis A, Suri MF, Ibrahim MS, Kirmani JF, et al. Feasibility of IA thrombolysis for acute ischemic stroke among anticoagulated patients. Neurocrit Care. 2007;7(2):152–5.

    PubMed  Google Scholar 

  51. Powers WJ, et al. Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2019;50:e344–418.

    PubMed  Google Scholar 

  52. Raychev R, et al. The impact of general anesthesia, baseline ASPECTS, time to treatment, and IV tPA on intracranial hemorrhage after neurothrombectomy: pooled analysis of the SWIFT PRIME, SWIFT, and STAR trials. J Neurointerv Surg. 2020;12:2–6.

    PubMed  Google Scholar 

  53. Boisseau W, et al. Predictors of parenchymal hematoma after mechanical thrombectomy: a multicenter study. Stroke. 2019;50:2364–70.

    PubMed  Google Scholar 

  54. Huang X, et al. Influence of procedure time on outcome and hemorrhagic transformation in stroke patients undergoing thrombectomy. J Neurol. 2019;266:2560–70.

    PubMed  Google Scholar 

  55. Alawieh A, et al. Impact of procedure time on outcomes of thrombectomy for stroke. J Am Coll Cardiol. 2019;73:879–90.

    PubMed  Google Scholar 

  56. Wan TF, Xu R, Zhao ZA, Lv Y, Chen HS, Liu L. Outcomes of general anesthesia versus conscious sedation for stroke undergoing endovascular treatment: a meta-analysis. BMC Anesthesiol. 2019;19:69.

    PubMed  PubMed Central  Google Scholar 

  57. Cappellari M, Pracucci G, Forlivesi S, et al. General anesthesia versus conscious sedation and local anesthesia during thrombectomy for acute ischemic stroke. Stroke. 2020;51(7):2036–44.

    CAS  PubMed  Google Scholar 

  58. Löwhagen Hendén P, Rentzos A, Karlsson JE, Rosengren L, Leiram B, Sundeman H, Dunker D, Schnabel K, Wikholm G, Hellström M, et al. General anesthesia versus conscious sedation for endovascular treatment of acute ischemic stroke: the an stroke trial (anesthesia during stroke). Stroke. 2017;48:1601–7.

    PubMed  Google Scholar 

  59. Mistry EA, et al. Systolic blood pressure within 24 hours after thrombectomy for acute ischemic stroke correlates with outcome. J Am Heart Assoc. 2017;6:10.1161.

    Google Scholar 

  60. Mistry EA, et al. Blood pressure after endovascular therapy for ischemic stroke (BEST): a multicenter prospective cohort study. Stroke. 2019;50:3449–55.

    PubMed  PubMed Central  Google Scholar 

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Luo, A., Misra, V., Birnbaum, L.A. (2022). Endovascular Reperfusion of Acute Large Vessel Occlusion Stroke. In: Edgell, R.C., M. Christopher, K. (eds) Neurointervention in the Medical Specialties. Current Clinical Neurology. Humana, Cham. https://doi.org/10.1007/978-3-030-87428-5_7

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  • DOI: https://doi.org/10.1007/978-3-030-87428-5_7

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