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Future of Aneurysm Surgery: Flow Disruption

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Neurointervention in the Medical Specialties

Part of the book series: Current Clinical Neurology ((CCNEU))

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Abstract

A cerebral aneurysm is a bulge on the wall of the blood vessel due to localized weakness of the vessel (Brisman et al. N Engl J Med. 355(9):928–39, 2006). The prevalence of cerebral aneurysms in the general population is 3–5% with approximate 1% risk of rupture per year. Ruptured aneurysms lead to great morbidity and mortality; hence, treatment before rupture must be considered. It has been well established that treatment of unruptured cerebral aneurysms will impact long-term outcomes (International Study of Unruptured Intracranial Aneurysms Investigators. N Engl J Med. 339(24):1725–33, 1998); however, the operative risk of 2–5% is not negligible. Several treatment options exist to disrupt intrasaccular flow dynamics, which will be discussed in this chapter. The treatment options for saccular disruption and aneurysm closure depend on several factors such as the aneurysm characteristics (aneurysm type, morphology, size, and location) as well as the aneurysm flow dynamics. Understanding these factors will optimize the choice of treatment and reduce operative risks. In this chapter, we will also discuss the available flow disruptors including those under investigation.

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Author information

Authors and Affiliations

  1. Saint Louis University, St. Louis, MO, USA

    Chike Ilorah

  2. Neuroscience Institute, DePaul Hospital and St. Louis University, St. Louis, MO, USA

    Chizoba Ezepue & Amer Alshekhlee

Authors
  1. Chike Ilorah
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  2. Chizoba Ezepue
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  3. Amer Alshekhlee
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Corresponding author

Correspondence to Amer Alshekhlee .

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Editors and Affiliations

  1. Neurology and Psychiatry, Saint Louis University, Saint Louis, MO, USA

    Randall C. Edgell

  2. Department of Neurology, Saint Louis University, St. Louis, MO, USA

    Kara M. Christopher

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Ilorah, C., Ezepue, C., Alshekhlee, A. (2022). Future of Aneurysm Surgery: Flow Disruption. In: Edgell, R.C., M. Christopher, K. (eds) Neurointervention in the Medical Specialties. Current Clinical Neurology. Humana, Cham. https://doi.org/10.1007/978-3-030-87428-5_18

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  • DOI: https://doi.org/10.1007/978-3-030-87428-5_18

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  • Publisher Name: Humana, Cham

  • Print ISBN: 978-3-030-87427-8

  • Online ISBN: 978-3-030-87428-5

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