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Arteriovenous Malformations of the Brain

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Neurointervention in the Medical Specialties

Part of the book series: Current Clinical Neurology ((CCNEU))

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Abstract

Brain arteriovenous malformations (AVMs) are complex vascular lesions characterized by a tangle of vessels with no interposed normal brain tissue. This tangle, the nidus, constitutes a high-flow vascular malformation connecting feeding arteries to draining veins. While relatively rare, AVMs are emphasized because of their potentially devastating effects on otherwise healthy young adults. In fact, AVMs are one of the leading causes of hemorrhagic stroke in young patients. We have seen a significant improvement in the management of AVMs over the past few decades. These classically challenging lesions have benefited from advances in the fields of microsurgery, endovascular surgery, and radiation oncology. Clinical trials have also helped refine our understanding of the natural history of the disease and the best management options. Despite these advances, AVM’s biologic and hemodynamic complexity still requires that each lesion be studied carefully and evaluated with a holistic approach to the patient to determine the best course of action (Bendok et al, Advances and innovations in brain arteriovenous malformation surgery. Neurosurgery 74:S60–S73, 2014).

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Authors and Affiliations

  1. Department of Neurosurgery, Saint Louis University School of Medicine, St. Louis, MO, USA

    Najib E. El Tecle, Samuel T. Griffin, Nabiha Quadri & Jeroen R. Coppens

  2. Department of Neurology, Saint Louis University Hospital, St. Louis, MO, USA

    Ahmed Abdelsalam

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  1. Najib E. El Tecle
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Correspondence to Jeroen R. Coppens .

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  1. Neurology and Psychiatry, Saint Louis University, Saint Louis, MO, USA

    Randall C. Edgell

  2. Department of Neurology, Saint Louis University, St. Louis, MO, USA

    Kara M. Christopher

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El Tecle, N.E., Abdelsalam, A., Griffin, S.T., Quadri, N., Coppens, J.R. (2022). Arteriovenous Malformations of the Brain. In: Edgell, R.C., M. Christopher, K. (eds) Neurointervention in the Medical Specialties. Current Clinical Neurology. Humana, Cham. https://doi.org/10.1007/978-3-030-87428-5_12

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