Abstract
This chapter concerns the possible use of natural molecules from vegetable sources in food and pharma preparations, including also the ambit of cosmetic industries. This possibility has been often considered with success in the recent years because of ‘natural’ claimed properties. In general, polyphenols and other substances named as ‘natural’ additives or nutraceuticals are considered and advertised as good surrogates for synthetic additives because of the following claimed feature at least: antioxidant power. In this ambit, the main part of natural antioxidant agents of vegetable origin is secondary metabolites responsible for different plant features and—consequently—food features such as colours and aroma: Phenolics; terpenoids; some proteins; chain-breakers or scavengers and, last but not least, vegetable enzymes and several mineral elements. Because of the relationship between oxidative stress (cause) and pathophysiological effects (illness) on the human health, the use of new and non-synthetic compounds with antioxidant power should be preferred and recommended in the ambit of well-balanced dietary lifestyles. Consequently, therapeutic or economic accessibility to antioxidants may be difficult, unless vegetable plants and herbal extracts are considered as strong antioxidant foods. In conclusion, the consumption of antioxidant compounds from readily and easily available foods of vegetable origin should be recommended when speaking of public health issues, and the promotion of traditional medicine may explain partially interesting medicinal effects in this ambit.
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Abbreviations
- AP:
-
Antioxidant Power
- MDD:
-
Metabolic Diseases and Disorder
- ROS:
-
Reactive Oxygen Species
- RNS:
-
Reactive Nitrogen Species
References
Albarracin SL, Stab B, Casas Z, Sutachan JJ, Samudio I, Gonzalez J, Capani F, Morales L, Barreto GE (2012) Effects of natural antioxidants in neurodegenerative disease. Nutr Neurosci 15(1):1–9. https://doi.org/10.1179/1476830511Y.0000000028
Apel M, Limberger RP, Sobral M, Menut C, Henriques A (2001) Chemical composition of the essential oil of Siphoneugena reitzii D. Legr. J Essent Oil Res 13(6):429–430. https://doi.org/10.1080/10412905.2001.9699716
Arulselvan P, Fard MT, Tan WS, Gothai S, Fakurazi S, Norhaizan ME, Kumar SS (2016) Role of antioxidants and natural products in inflammation. Oxid Med Cell Longev 2016:Article ID 5276130. https://doi.org/10.1155/2016/5276130
Balsano C, Alisi A (2009) Antioxidant effects of natural bioactive compounds. Curr Pharm Des 15(26):3063–3073. https://doi.org/10.2174/138161209789058084
Batista R (2014) Uses and potential applications of ferulic acid. Warren B (ed) Ferulic acid: antioxidant properties, uses and potential health benefits, 1st edn. Nova Science Publishers Inc., New York, pp 39–70
Bicas JL, Neri-Numa IA, Ruiz ALTG, De Carvalho JE, Pastore GM (2011) Evaluation of the antioxidant and antiproliferative potential of bioflavors. Food Chem Toxicol 49(7):1610–1615. https://doi.org/10.1016/j.fct.2011.04.012
Campêlo LML (2011) Pharmacological evaluation of the essential oil of Citrus limon (Burm) central nervous system: a study behavioral, neurochemical and histological. Dissertation, Federal University of Piauí, Teresina, Brazil
Choi DY, Lee YJ, Hong JT, Lee HJ (2012) Antioxidant properties of natural polyphenols and their therapeutic potentials for Alzheimer’s disease. Brain Res Bull 87(2–3):144–153. https://doi.org/10.1016/j.brainresbull.2011.11.014
Costa Junior JS, Ferraz ABF, Filho BAB, Feitosa CM, Citó AMGL, Freitas RM, Saffi J (2011) Evaluation of antioxidant effects in vitro of garcinielliptone FC (GFC) isolated from Platonia insignis Mart. J Med Plants Res 5(2):293–299
De B, Bhandari K, Singla RK, Saha G, Goswami TK (2020) In silico molecular GRIP docking of some secondary metabolites combating diabesity. Bull Natl Res Centre 44(1):1–13. https://doi.org/10.1186/s42269-020-00327-7
de Oliveira TM, de Carvalho RBF, da Costa IHF, de Oliveira GAL, de Souza AA, de Lima SG, de Freitas RM (2015) Evaluation of p-cymene, a natural antioxidant. Pharm Biol 53(3):423–428. https://doi.org/10.3109/13880209.2014.923003
Delgado AM, Vaz Almeida MD, Parisi S (2016) Chemistry of the Mediterranean Diet. Springer International Publishing, Cham, Switzerland. https://doi.org/10.1007/978-3-319-29370-7
Frei B (ed) (2012) Natural antioxidants in human health and disease. Academic Press, San Diego
Freitas RM (2001) Antioxidant properties and therapeutic potential of essential oils. In: Sousa DP (ed) Medicinal essential oils: chemical, pharmacological and therapeutic aspects. New Science Publishers, New York, pp 1–9
Freitas RM (2009) The evaluation of effects of lipoic acid on the lipid peroxidation, nitrite formation and antioxidant enzymes in the hippocampus of rats after pilocarpine-induced seizures. Neurosci Lett 455(2):140–144. https://doi.org/10.1016/j.neulet.2009.03.065
Haddad MA, Dmour H, Al-Khazaleh JFM, Obeidat M, Al-Abbadi A, Al-Shadaideh AN, Al-mazra’awi MS, Shatnawi MA, Iommi C (2020) Herbs and medicinal plants in Jordan. J AOAC Int 103(4):925–929. https://doi.org/10.1093/jaocint/qsz026
Haddad MA, El-Qudah J, Abu-Romman S, Obeidat M, Iommi C, Jaradat DSM (2020) Phenolics in Mediterranean and Middle East important fruits. J AOAC Int 103(4):930–934. https://doi.org/10.1093/jaocint/qsz027
Hertog MG, Feskens EJ, Kromhout D, Hollman PCH, Katan MB (1993) Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 342(8878):1007–1011. https://doi.org/10.1016/0140-6736(93)92876-U
Imran M, Ghorat F, Ul-Haq I, Ur-Rehman H, Aslam F, Heydari M, Shariati MA, Okuskhanova E, Yessimbekov Z, Thiruvengadam M, Hashempur MA, Rebezov M (2020) Lycopene as a natural antioxidant used to prevent human health disorders. Antioxid 9(8):706. https://doi.org/10.3390/antiox9080706
Issaoui M, Delgado AM, Caruso G, Micali M, Barbera M, Atrous H, Ouslati A, Chammem N (2020) Phenols, flavors, and the Mediterranean diet. J AOAC Int 103(4):915–924. https://doi.org/10.1093/jaocint/qsz018
Kaur C, Kapoor HC (2002) Anti-oxidant activity and total phenolic content of some Asian vegetables. Int J Food Sci Technol 37(2):153–161. https://doi.org/10.1046/j.1365-2621.2002.00552.x
Laganà P, Anastasi G, Marano F, Piccione S, Singla RK, Dubey AK, Coniglio MA, Facciolà A, Di Pietro A, Haddad MA, Al-Hiary M, Caruso G (2019) Phenolic substances in foods: health effects as anti-inflammatory and antimicrobial agents. J AOAC Int 102(5):1378–1387. https://doi.org/10.1093/jaoac/102.5.1378
Maciel MAM, Pinto AC, Veiga Junior VF, Grynberg NF, Echevarria A (2002) Medicinal plants: the need for multidisciplinary studies. New Chem 25(3):429–438. https://doi.org/10.1590/S0100-40422002000300016
Martins Gregório B, Benchimol De Souza D, de Morais A, Nascimento F, Matta L, Fernandes-Santos C (2016) The potential role of antioxidants in metabolic syndrome. Curr Pharm Des 22(7):859–869. https://doi.org/10.2174/1381612822666151209152352
Maxwell SR (1995) Prospects for the use of antioxidant therapies. Drugs 49(3):345–361. https://doi.org/10.2165/00003495-199549030-00003
Mengues SS, Mentz LA, Schenkel EP (2011) Use of medicinal plants in pregnancy. Rev Bras Farmacogn 11:21–35
Mothana RAA, Hasson SS, Schultze W, Mowitz A, Lindequist U (2001) Phytochemical composition and in vitro antimicrobial and antioxidant activities of essential oils of three endemic Soqotraen boswellia species. Food Chem 126:1149–1154
Nogueira Neto JD, Sousa DP, Freitas RM (2013) Evaluation of antioxidant potential in vitro of nerolidol. J Pharmaceut Sci Basic Appl 34:125–130
Parisi S (2020) Characterization of major phenolic compounds in selected foods by the technological and health promotion viewpoints. J AOAC Int 103(4):904–905. https://doi.org/10.1093/jaoacint/qsaa011
Podsędek A (2007) Natural antioxidants and antioxidant capacity of Brassica vegetables: a review. LWT-Food Sci Technol 40(1):1–11. https://doi.org/10.1016/j.lwt.2005.07.023
Rafieian-Kopaei M, Baradaran A, Rafieian M (2013) Plants anti-oxidants: from laboratory to clinic. J Nephropathol 2(2):152–153. https://doi.org/10.12860/JNP.2013.26
Ruberto G, Baratta MT (2000) Antioxidant activity of selected essential oil components in two lipid model systems. Food Chem 69:167–174. https://doi.org/10.1016/S0308-8146(99)00247-2
Santos PS, Costa JP, Tome´ AR, Saldanha GB, de Souza GF, Feng D, de Freitas RM (2011) Oxidative stress in rat striatum af-ter pilocarpine-induced seizures is diminished by alphatocopherol. Eur J Pharmacol 668(1–2):65–71.https://doi.org/10.1016/j.ejphar.2011.06.035
Scotti L, Singla RK, Scotti MT (2016) Editorial (thematic issue: natural leads in drug discovery against metabolic disorders and their related infectious diseases). Curr Top Med Chem 16(23):2523–2524. https://doi.org/10.2174/1568026616999160510121418
Shen B, Singla RK (2020) Secondary metabolites as treatment of choice for metabolic disorders and infectious diseases & their metabolic profiling-Part 2. Curr Drug Metab 21(14):1070–1071. https://doi.org/10.2174/138920022114201230142204
Shen L, Shen K, Bai J, Wang J, Singla RK, Shen B (2020) Data-driven microbiota biomarker discovery for personalized drug therapy of cardiovascular disease. Pharmacol Res 161:105225. https://doi.org/10.1016/j.phrs.2020.105225
Singla RK (2020) Secondary metabolites as treatment of choice for metabolic disorders and infectious diseases and their metabolic profiling: Part 1. Curr Drug Metab 21(7):480–481. https://doi.org/10.2174/138920022107200925101631
Singla RK, Ali M, Kamal MA, Dubey AK (2018) Isolation and characterization of nuciferoic acid, a novel keto fatty acid with hyaluronidase inhibitory activity from Cocos nucifera Linn. Endocarp. Curr Top Med Chem 18(27):2367–2378. https://doi.org/10.2174/1568026619666181224111319
Veiga Junior VF, Pinto AC, Maciel MAM (2005) Medicinal plants: safe cure? New Chem 28(3):519–528. https://doi.org/10.1590/S0100-40422005000300026
Wang S, Melnyk JP, Tsao R, Marcone MF (2011) How natural dietary antioxidants in fruits, vegetables and legumes promote vascular health. Food Res Int 44(1):14–22. https://doi.org/10.1016/j.foodres.2010.09.028
Wannes WA, Mhamdi B, Sriti J, Jemia MB, Ouchikh O, Hamdaoui G, Kchouk ME, Marzouk B (2010) Antioxidant activities of the essential oils and methanol extracts from myrtle (Myrtus communis var. italica L.) leaf, stem and flower. Food Chem Toxicol 48(5):1362–1370. https://doi.org/10.1016/j.fct.2010.03.002
Wickens AP (2001) Ageing and the free radical theory. Respir Physiol 128(3):379–391. https://doi.org/10.1016/S0034-5687(01)00313-9
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Sharma, R.K., Micali, M., Rana, B.K., Pellerito, A., Singla, R.K. (2021). Natural Antioxidant Agents for Treatment of Metabolic Diseases and Disorders. In: Indian Herbal Medicines. SpringerBriefs in Molecular Science(). Springer, Cham. https://doi.org/10.1007/978-3-030-80918-8_4
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