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Coxsackievirus and Adenovirus Receptor (CXADR): Recent Findings and Its Role and Regulation in Spermatogenesis

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Molecular Mechanisms in Spermatogenesis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1381))

Abstract

Coxsackievirus and adenovirus receptor (CXADR) belongs to immunoglobulin superfamily of cell adhesion molecules. It expresses in most tissues, but displays unique and indispensable functions in some tissues such as heart and testis. CXADR is a multifunctional protein that can serve as a viral receptor, a junction structural protein and a signalling molecule. Thus, it exerts a wide range of functions such as facilitating leukocyte transmigration, regulating barrier function and cell adhesion, promoting EMT transition, and mediating spermatogenesis. This review aims to provide an overview and highlights some recent findings on CXADR in the field with emphasis on studies in the testis, upon which future studies can be designed to delineate the roles and regulation of CXADR in spermatogenesis.

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Acknowledgement

Grant support: The work was funded by Hong Kong Research Grants Council (17100816) and HKU/CRCG Seed Funding for Basic Research.

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  1. School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong

    Yang Zhang & Wing-Yee Lui

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  1. Yang Zhang
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Correspondence to Wing-Yee Lui .

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  1. Sir Run Run Shaw Hospital (SRRSH), Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

    C.Yan Cheng

  2. Sir Run Run Shaw Hospital (SRRSH), Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

    Fei Sun

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Zhang, Y., Lui, WY. (2021). Coxsackievirus and Adenovirus Receptor (CXADR): Recent Findings and Its Role and Regulation in Spermatogenesis. In: Cheng, C., Sun, F. (eds) Molecular Mechanisms in Spermatogenesis. Advances in Experimental Medicine and Biology, vol 1381. Springer, Cham. https://doi.org/10.1007/978-3-030-77779-1_5

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