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Ocular Inflammation

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Lee's Ophthalmic Histopathology

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Abstract

This chapter deals predominantly with inflammatory disease in the eye as it is seen in surgical enucleation specimens. Operative procedures may be complicated by secondary exogenous infection in a small percentage of total cases treated surgically. Non-surgical trauma may also be complicated by infection. Endogenous infection occurs due to haematogenous spread from a primary source elsewhere in the body such as a lung abscess. If the inflammatory process is restricted to the tissues within the scleral envelope, the condition is referred to as endophthalmitis; if the episcleral tissues are involved, the term panophthalmitis is appropriate. Whilst infection is an important cause of ocular inflammation rheumatoid eye disease may cause a sight threatening sclerokeratitis due to immune complex mediated vasculitis. Other systemic conditions such as Granulomatosis with polyangiitis may cause sclerokeratitis so a serological screen is important. Vogt-Koyanagi-Harada Syndrome is an autoimmune condition that may cause a granulomatous uveitis identical to sympathetic ophthalmitis but without the prior history of trauma.

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Authors and Affiliations

  1. Department of Pathology, Queen Elizabeth University Hospital, Glasgow, UK

    Fiona Roberts

  2. Department of Pathology, Royal Infirmary of Edinburgh, Edinburgh, UK

    Chee Koon Thum

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  1. Fiona Roberts
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  2. Chee Koon Thum
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Correspondence to Fiona Roberts .

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Roberts, F., Thum, C.K. (2021). Ocular Inflammation. In: Lee's Ophthalmic Histopathology. Springer, Cham. https://doi.org/10.1007/978-3-030-76525-5_6

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  • DOI: https://doi.org/10.1007/978-3-030-76525-5_6

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