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Absolute Glaucoma

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Abstract

Glaucoma is a generic term used to describe diseases in which the intraocular pressure is at a level sufficient to cause damage to the tissues within an individual eye, resulting in “glaucomatous optic neuropathy”. Around 30% of the globes received in the laboratory will have been enucleated due to failed treatment for glaucoma. Glaucoma may be classified as primary open angle, primary acute angle closure, congenital glaucoma and secondary glaucoma where the chamber angle may be closed due to a fibrovascular membrane or where the chamber angle is open but the trabecular meshwork is blocked (e.g. with blood or tumour cells). A rapid rise in intraocular pressure will result in acute ischaemic damage to ocular tissues and may cause infarction in the optic nerve. A chronic sustained raised intraocular pressure leads to atrophy of intraocular tissues with loss of the ganglion cell layer of the retina and the prelaminar region of the optic nerve with bowing of the lamina cribrosa posteriorly. The changes of surgical intervention will also usually be evident in enucleation specimens.

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Authors and Affiliations

  1. Department of Pathology, Queen Elizabeth University Hospital, Glasgow, UK

    Fiona Roberts

  2. Department of Pathology, Royal Infirmary of Edinburgh, Edinburgh, UK

    Chee Koon Thum

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Roberts, F., Thum, C.K. (2021). Absolute Glaucoma. In: Lee's Ophthalmic Histopathology. Springer, Cham. https://doi.org/10.1007/978-3-030-76525-5_3

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  • Print ISBN: 978-3-030-76524-8

  • Online ISBN: 978-3-030-76525-5

  • eBook Packages: MedicineMedicine (R0)

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