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The Corneal Disc

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Lee's Ophthalmic Histopathology

Abstract

Corneal transplantation is one of the most successful forms of homograft. This can be undertaken for a variety of diseases that cause corneal opacification, vascularisation, scarring and ulceration. Keratoplasty has transformed in recent years and although penetrating keratoplasty is still performed on a wide range of conditions techniques such as deep anterior lamellar keratoplasty for anterior pathology and Descemet’s membrane stripping with endothelial keratoplasty for posterior problems is now commonplace. The most common cause for keratoplasty used to be bullous keratopathy related to endothelial cell deficiency caused by anterior chamber lens implants. This has now decreased incidence and keratoconus is more common. There are also a host of infectious agents which cause keratitis including bacteria, fungi and parasites. Corneal dystrophies are uncommon but of pathological interest and can affect the anterior cornea and Bowman’s layer, the stroma and the endothelium. A significant number of specimens will result from repeat keratoplasty and the potential findings in these specimens include inflammation in relation to the host graft junction and endothelium, a retrocorneal fibrous membrane or simply loss of endothelial cells. The cornea may also be subject to mechanical trauma, burns and damage by heat and irradiation.

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  1. Department of Pathology, Queen Elizabeth University Hospital, Glasgow, UK

    Fiona Roberts

  2. Department of Pathology, Royal Infirmary of Edinburgh, Edinburgh, UK

    Chee Koon Thum

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Roberts, F., Thum, C.K. (2021). The Corneal Disc. In: Lee's Ophthalmic Histopathology. Springer, Cham. https://doi.org/10.1007/978-3-030-76525-5_13

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