Aging in the Human Species

Libertini, Giacinto; Corbi, Graziamaria; Conti, Valeria; Shubernetskaya, Olga; Ferrara, Nicola

doi:10.1007/978-3-030-73774-0_6

Giacinto Libertini⁹,
Graziamaria Corbi¹⁰,
Valeria Conti¹¹,
Olga Shubernetskaya¹² &
…
Nicola Ferrara¹³

Part of the book series: Advances in Studies of Aging and Health ((ADSAH,volume 2))

314 Accesses

Abstract

The result of the actions of the telomere-subtelomere-telomerase system, in our species and in many similar species, is the atrophic syndrome, already briefly outlined in the preceding Chapter 5 – Subtelomere-Telomere aging theory, which manifests itself progressively and in relation to age in all tissues and organs. The characteristics of the atrophic syndrome are now discussed with more details.

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References

Aarsland, D., Londos, E., & Ballard, C. (2009). Parkinson’s disease dementia and dementia with Lewy bodies: Different aspects of one entity. International Psychogeriatrics, 21(2), 216–219. https://doi.org/10.1017/S1041610208008612.
Article Google Scholar
Abbott, A. (2008). The plaque plan. Nature, 456(7219), 161–164. https://doi.org/10.1038/456161a.
Article Google Scholar
Abu Eid, R., Sawair, F., Landini, G., & Saku, T. (2012). Age and the architecture of oral mucosa. Age (Dordrecht, Netherlands), 34(3), 651–658. https://doi.org/10.1007/s11357-011-9261-1.
Article Google Scholar
Adams, V., Gielen, S., Hambrecht, R., & Schuler, G. (2001). Apoptosis in skeletal muscle. Frontiers in Bioscience, 6, D1–D11.
Article Google Scholar
Alberts, B., Bray, D., Hopkin, K., Johnson, A., Lewis, J., Raff, M., Roberts, K., & Walter, P. (Eds.). (2014). Essential cell biology (4th ed.). New York: Garland Science.
Google Scholar
Andrew, W., & Andrew, N. V. (1957). An age involution in the small intestin of the mouse. Journal of Gerontology, 12(2), 136–149. https://doi.org/10.1093/geronj/12.2.136.
Article Google Scholar
Anversa, P., Kajstura, J., Leri, A., & Bolli, R. (2006). Life and death of cardiac stem cells. Circulation, 113(11), 1451–1463. https://doi.org/10.1161/CIRCULATIONAHA.105.595181.
Article Google Scholar
Armanios, M., Alder, J. K., Parry, E. M., Karim, B., Strong, M. A., & Greider, C. W. (2009). Short telomeres are sufficient to cause the degenerative defects associated with aging. American Journal of Human Genetics, 85(6), 823–832. https://doi.org/10.1016/j.ajhg.2009.10.028.
Article Google Scholar
Aronow, W. S. (1998). Effects of aging on the heart. In R. C. Tallis, H. M. Fillit, & J. C. Brocklehurst (Eds.), Brocklehurst’s textbook of geriatric medicine and gerontology (5th ed., pp. 255–262). New York: Churchill Livingstone.
Google Scholar
Artandi, S. E. (2002). Telomere shortening and cell fates in mouse models of neoplasia. Trends in Molecular Medicine, 8(1), 44–47. https://doi.org/10.1016/s1471-4914(01)02222-5.
Article Google Scholar
Attems, J., Walker, L., & Jellinger, K. A. (2015). Olfaction and aging: A mini-review. Gerontology, 61(6), 485–490. https://doi.org/10.1159/000381619.
Article Google Scholar
Baime, M. J., Nelson, J. B., & Castell, D. O. (1994). Aging of the gastrointestinal system. In W. R. Hazzard, J. Blass, W. H. Ettinger, J. Halter, & J. Ouslander (Eds.), Principles of geriatric medicine and gerontology (3rd ed., pp. 665–681). New York: McGraw-Hill.
Google Scholar
Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., & Clevers, H. (2007). Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature, 449(7165), 1003–1007. https://doi.org/10.1038/nature06196.
Article Google Scholar
Barnett-Cowan, M., Dyde, R. T., Foxe, S. H., Moro, E., Hutchison, W. D., & Harris, L. R. (2010). Multisensory determinants of orientation perception in Parkinson’s disease. Neuroscience, 167(4), 1138–1150. https://doi.org/10.1016/j.neuroscience.2010.02.065.
Article Google Scholar
Barresi, M., Ciurleo, R., Giacoppo, S., Foti Cuzzola, V., Celi, D., Bramanti, P., & Marino, S. (2012). Evaluation of olfactory dysfunction in neurodegenerative diseases. Journal of the Neurological Sciences, 323(1–2), 16–24. https://doi.org/10.1016/j.jns.2012.08.028.
Article Google Scholar
Beltrami, A. P., Urbanek, K., Kajstura, J., Yan, S. M., Finato, N., Bussani, R., Nadal-Ginard, B., Silvestri, F., Leri, A., Beltrami, C. A., & Anversa, P. (2001). Evidence that human cardiac myocytes divide after myocardial infarction. The New England Journal of Medicine, 334(23), 1750–1757. https://doi.org/10.1056/NEJM200106073442303.
Article Google Scholar
Benedetti, A., Jezequel, A. M., & Orlandi, F. (1988). A quantitative evaluation of apoptotic bodies in rat liver. Liver, 8(3), 172–177. https://doi.org/10.1111/j.1600-0676.1988.tb00987.x.
Article Google Scholar
Ben-Porath, I., & Weinberg, R. (2005). The signals and pathways activating cellular senescence. The International Journal of Biochemistry & Cell Biology, 37(5), 961–976. https://doi.org/10.1016/j.biocel.2004.10.013.
Article Google Scholar
Berger, J. M., Fine, S. L., & Maguire, M. G. (1999). Age-related macular degeneration. St. Louis: Mosby.
Google Scholar
Bermingham-McDonogh, O., & Reh, T. A. (2011). Regulated reprogramming in the regeneration of sensory receptor cells. Neuron, 71(3), 389–405. https://doi.org/10.1016/j.neuron.2011.07.015.
Article Google Scholar
Bertram, L., Blacker, D., Mullin, K., Keeney, D., Jones, J., Basu, S., Yhu, S., McInnis, M. G., Go, R. C., Vekrellis, K., Selkoe, D. J., Saunders, A. J., & Tanzi, R. E. (2000). Evidence for genetic linkage of Alzheimer’s disease to chromosome 10q. Science, 290(5500), 2302–2303. https://doi.org/10.1126/science.290.5500.2302.
Article Google Scholar
Bijlsma, A. Y., Meskers, C. G., Westendorp, R. G., & Maier, A. B. (2012). Chronology of age-related disease definitions: Osteoporosis and sarcopenia. Ageing Research Reviews, 11(2), 320–324. https://doi.org/10.1016/j.arr.2012.01.001.
Article Google Scholar
Blackburn, E. H. (2000). Telomere states and cell fates. Nature, 408(6808), 53–56. https://doi.org/10.1038/35040500.
Article Google Scholar
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C. P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998). Extension of life-span by introduction of telomerase into Normal human cells. Science, 279(5349), 349–352. https://doi.org/10.1126/science.279.5349.349.
Article Google Scholar
Bonner-Weir, S. (2000). Islet growth and development in the adult. Journal of Molecular Endocrinology, 24(3), 297–302. https://doi.org/10.1677/jme.0.0240297.
Article Google Scholar
Branchet, M. C., Boisnic, S., Frances, C., & Robert, A. M. (1990). Skin thickness changes in normal aging skin. Gerontology, 36(1), 28–35. https://doi.org/10.1159/000213172.
Article Google Scholar
Brodie, S. E. (1998). Aging and disorders of the eye. In R. C. Tallis, F. Hm, & J. C. Brocklehurst (Eds.), Brocklehurst’s textbook of geriatric medicine and gerontology (5th ed., pp. 659–672). New York: Churchill Livingstone.
Google Scholar
Brück, D., Wenning, G. K., Stefanova, N., & Fellner, L. (2016). Glia and alpha-synuclein in neurodegeneration: A complex interaction. Neurobiology of Disease, 85, 262–274. https://doi.org/10.1016/j.nbd.2015.03.003.
Article Google Scholar
Buchtová, M., Stembírek, J., Glocová, K., Matalová, E., & Tucker, A. S. (2012). Early regression of the dental Lamina underlies the development of Diphyodont dentitions. Journal of Dental Research, 91(5), 491–498. https://doi.org/10.1177/0022034512442896.
Article Google Scholar
Caballol, N., Martí, M. J., & Tolosa, E. (2007). Cognitive dysfunction and dementia in Parkinson disease. Movement Disorders, 22(Suppl 17), S358–S366. https://doi.org/10.1002/mds.21677.
Article Google Scholar
Caggiano, M., Kauer, J. S., & Hunter, D. D. (1994). Globose basal cells are neuronal progenitors in the olfactory epithelium: A lineage analysis using a replication-incompetent retrovirus. Neuron, 13(2), 339–352. https://doi.org/10.1016/0896-6273(94)90351-4.
Article Google Scholar
Cain, W. S., & Stevens, J. C. (1989). Uniformity of olfactory loss in aging. Annals of the New York Academy of Sciences, 561, 29–38. https://doi.org/10.1111/j.1749-6632.1989.tb20967.x.
Article Google Scholar
Caird, F. I., & Dall, J. L. C. (1978). The cardiovascular system. In J. C. Brocklehurst (Ed.), Textbook of geriatric medicine and gerontology (2nd ed., pp. 125–157). New York: Churchill Livingstone.
Google Scholar
Calleja-Agius, J., Brincat, M., & Borg, M. (2013). Skin connective tissue and ageing. Best Practice & Research. Clinical Obstetrics & Gynaecology, 27(5), 727–740. https://doi.org/10.1016/j.bpobgyn.2013.06.004.
Article Google Scholar
Candia, O. A. (2004). Electrolyte and fluid transport across corneal, conjunctival and lens epithelia. Experimental Eye Research, 78(3), 527–535. https://doi.org/10.1016/j.exer.2003.08.015.
Article Google Scholar
Cardani, R., & Zavanella, T. (2000). Age-related cell proliferation and apoptosis in the kidney of male Fischer 344 rats with observations on a spontaneous tubular cell adenoma. Toxicologic Pathology, 28(6), 802–806. https://doi.org/10.1177/019262330002800606.
Article Google Scholar
Cerasi, E., Kaiser, N., & Leibowitz, G. (2000). Type 2 diabetes and beta cell apoptosis (article in French). Diabetes & Metabolism, 26(Suppl 3), 13–16.
Google Scholar
Chacko, C. J., Paulson, K. A., Mathan, V. I., & Baker, S. J. (1969). The villus architecture of the small intestine in the tropics: A necropsy study. The Journal of Pathology, 98(2), 146–151. https://doi.org/10.1002/path.1710980209.
Article Google Scholar
Chauhan, J. (1989). Relationships between sour and salt taste perception and selected subject attributes. Journal of the American Dietetic Association, 89(5), 652–658.
Article Google Scholar
Chen, X., Fang, H., & Schwob, J. E. (2004). Multipotency of purified, transplanted globose basal cells in olfactory epithelium. The Journal of Comparative Neurology, 469(4), 457–474. https://doi.org/10.1002/cne.11031.
Article Google Scholar
Chimenti, C., Kajstura, J., Torella, D., Urbanek, K., Heleniak, H., Colussi, C., Di Meglio, F., Nadal-Ginard, B., Frustaci, A., Leri, A., Maseri, A., & Anversa, P. (2003). Senescence and death of primitive cells and myocytes lead to premature cardiac aging and heart failure. Circulation Research, 93(7), 604–613. https://doi.org/10.1161/01.RES.0000093985.76901.AF.
Article Google Scholar
Chłopicki, S., & Gryglewski, R. J. (2005). Angiotensin converting enzyme (ACE) and HydroxyMethylGlutaryl-CoA (HMG-CoA) reductase inhibitors in the forefront of pharmacology of endothelium. Pharmacological Reports, 57S, 86–96.
Google Scholar
Chu, H.-P., Cifuentes-Rojas, C., Kesner, B., Aeby, E., Lee, H.-G., Wei, C., Oh, H. J., Boukhali, M., Haas, W., & Lee, J. T. (2017). TERRA RNA antagonizes ATRX and protects telomeres. Cell, 170(1), 86–101. https://doi.org/10.1016/j.cell.2017.06.017.
Article Google Scholar
Chu, H.-P., Froberg, J. E., Kesner, B., Oh, H. J., Ji, F., Sadreyev, R., Pinter, S. F., & Lee, J. T. (2017). PAR-TERRA directs homologous sex chromosome pairing. Nature Structural & Molecular Biology, 24(8), 620–631. https://doi.org/10.1038/nsmb.3432.
Article Google Scholar
Connolly, M. J. (1998). Age-related changes in the respiratory system. In R. C. Tallis, H. M. Fillit, & J. C. Brocklehurst (Eds.), Brocklehurst’s textbook of geriatric medicine and gerontology (5th ed., pp. 1073–1078). New York: Churchill Livingstone.
Google Scholar
Cooper, C., & Melton, L. J., 3rd. (1992). Epidemiology of osteoporosis. Trends in Endocrinology and Metabolism, 3(6), 224–229. https://doi.org/10.1016/1043-2760(92)90032-v.
Article Google Scholar
Counter, C. M., Hahn, W. C., Wei, W., Caddle, S. D., Beijersbergen, R. L., Lansdorp, P. M., Sedivy, J. M., & Weinberg, R. A. (1998). Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Proceedings of the National Academy of Sciences of the United States of America, 95(25), 14723–14728. https://doi.org/10.1073/pnas.95.25.14723.
Article Google Scholar
Cowie, C. C., Rust, K. F., Byrd-Holt, D. D., Eberhardt, M. S., Flegal, K. M., Engelgau, M. M., Saydah, S. H., Williams, D. E., Geiss, L. S., & Gregg, E. W. (2006). Prevalence of diabetes and impaired fasting glucose in adults in the U.S. population: National Health and Nutrition Examination Survey 1999–2002. Diabetes Care, 29(6), 1263–1268. https://doi.org/10.2337/dc06-0062.
Article Google Scholar
Crouch, R. K., Koutalos, Y., Kono, M., Schey, K., & Ablonczy, Z. (2015). A2E and Lipofuscin. Progress in Molecular Biology and Translational Science, 134, 449–463. https://doi.org/10.1016/bs.pmbts.2015.06.005.
Article Google Scholar
Cumming, W. J. K. (1998). Aging and neuromuscolar disease. In R. C. Tallis, H. M. Fillit, & J. C. Brocklehurst (Eds.), Brocklehurst’s textbook of geriatric medicine and gerontology (5th ed., pp. 1115–1130). New York: Churchill Livingstone.
Google Scholar
Cusanelli, E., & Chartrand, P. (2015). Telomeric repeat-containing RNA TERRA: A noncoding RNA connecting telomere biology to genome integrity. Frontiers in Genetics, 6, 143. https://doi.org/10.3389/fgene.2015.00143.
Article Google Scholar
D’Emic, M. D., Whitlock, J. A., Smith, K. M., Fisher, D. C., & Wilson, J. A. (2013). Evolution of high tooth replacement rates in sauropod dinosaurs. PLoS One, 8(7), e69235. https://doi.org/10.1371/journal.pone.0069235.
Article Google Scholar
David, H., & Reinke, P. (1988). Liver morphology with aging. In L. Bianchi, P. Holt, & O. F. W. James (Eds.), Aging in liver and gastro-intestinal tracts (pp. 143–159). Lancaster: MTP Press.
Google Scholar
Davidson, M. H. (2007). Overview of prevention and treatment of atherosclerosis with lipid-altering therapy for pharmacy directors. The American Journal of Managed Care, 13(Suppl 10), S260–S269.
Google Scholar
Davie, C. A. (2008). A review of Parkinson’s disease. British Medical Bulletin, 86, 109–127. https://doi.org/10.1093/bmb/ldn013.
Article Google Scholar
Davies, C. T. M., Thomas, D. O., & White, M. J. (1986). Mechanical properties of young and elderly human muscle. Acta Medica Scandinavica, 711, 219–226. https://doi.org/10.1111/j.0954-6820.1986.tb08954.x.
Article Google Scholar
de Lange, T., & Jacks, T. (1999). For better or worse? Telomerase inhibition and cancer. Cell, 98(3), 273–275. https://doi.org/10.1016/s0092-8674(00)81955-8.
Article Google Scholar
de Lau, L. M., & Breteler, M. M. (2006). Epidemiology of Parkinson’s disease. Lancet Neurology, 5(6), 525–535. https://doi.org/10.1016/S1474-4422(06)70471-9.
Article Google Scholar
DePinho, R. A. (2000). The age of cancer. Nature, 408(6809), 248–254. https://doi.org/10.1038/35041694.
Article Google Scholar
Devlin, H., & Ferguson, M. W. J. (1998). Aging and the Orofacial tissues. In R. C. Tallis, H. M. Fillit, & J. C. Brocklehurst (Eds.), Brocklehurst’s textbook of geriatric medicine and gerontology (5th ed., pp. 789–802). New York: Churchill Livingstone.
Google Scholar
Dickson, D. W. (2007). Neuropathology of movement disorders. In J. Jankovic & E. Tolosa (Eds.), Parkinson’s disease and movement disorders (pp. 271–283). Philadelphia: Lippincott Williams and Wilkins.
Google Scholar
Dieppe, P., & Tobias, J. (1998). Bone and joint aging. In R. C. Tallis, H. M. Fillit, & J. C. Brocklehurst (Eds.), Brocklehurst’s textbook of geriatric medicine and gerontology (5th ed., pp. 1131–1135). New York: Churchill Livingstone.
Google Scholar
Dixon, J. B., & O’Brien, P. E. (2006). Obesity and the white blood cell count: Changes with sustained weight loss. Obesity Surgery, 16(3), 251–257. https://doi.org/10.1381/096089206776116453.
Article Google Scholar
Dorsey, E. R., Constantinescu, R., Thompson, J. P., Biglan, K. M., Holloway, R. G., Kieburtz, K., Marshall, F. J., Ravina, B. M., Schifitto, G., Siderowf, A., & Tanner, C. M. (2007). Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030. Neurology, 68(5), 384–386. https://doi.org/10.1212/01.wnl.0000247740.47667.03.
Article Google Scholar
Doty, R. L. (2012). Olfactory dysfunction in Parkinson disease. Nature Reviews. Neurology, 8(6), 329–339. https://doi.org/10.1038/nrneurol.2012.80.
Article Google Scholar
Doty, R. L., & Kamath, V. (2014). The influences of age on olfaction: A review. Frontiers in Psychology, 5, 20. https://doi.org/10.3389/fpsyg.2014.00020.
Article Google Scholar
Doty, R. L., Shaman, P., Applebaum, S. L., Giberson, R., Siksorski, L., & Rosenberg, L. (1984). Smell identification ability: Changes with age. Science, 226(4681), 1441–1443. https://doi.org/10.1126/science.6505700.
Article Google Scholar
Dremier, S., Golstein, J., Mosselmans, R., Dumont, J. E., Galand, P., & Robaye, B. (1994). Apoptosis in dog thyroid cells. Biochemical and Biophysical Research Communications, 200(1), 52–58. https://doi.org/10.1006/bbrc.1994.1412.
Article Google Scholar
Duff, K., McCaffrey, R. J., & Solomon, G. S. (2002). The pocket smell test: Successfully discriminating probable Alzheimer’s dementia from vascular dementia and major depression. The Journal of Neuropsychiatry and Clinical Neurosciences, 14(2), 197–201. https://doi.org/10.1176/jnp.14.2.197.
Article Google Scholar
Duffy, V. B., Backstrand, J. R., & Ferris, A. M. (1995). Olfactory dysfunction and related nutritional risk in free-living, elderly women. Journal of the American Dietetic Association, 95(8), 879–884. https://doi.org/10.1016/S0002-8223(95)00244-8.
Article Google Scholar
Dyck, P. J., Schultz, P. W., & O’Brien, P. C. (1972). Quantitation of touch-pressure sensation. Archives of Neurology, 26(5), 465–473. https://doi.org/10.1001/archneur.1972.00490110099010.
Article Google Scholar
Ellul, J., Archer, N., Foy, C. M., Poppe, M., Boothby, H., Nicholas, H., Brown, R. G., & Lovestone, S. (2007). The effects of commonly prescribed drugs in patients with Alzheimer’s disease on the rate of deterioration. Journal of Neurology, Neurosurgery, and Psychiatry, 78(3), 233–239. https://doi.org/10.1136/jnnp.2006.104034.
Article Google Scholar
Elmore, S. (2007). Apoptosis: A review of programmed cell death. Toxicologic Pathology, 35(4), 495–516. https://doi.org/10.1080/01926230701320337.
Article Google Scholar
Enright, P. L., Kronmal, R. A., Higgins, M., Schenker, M., & Haponik, E. F. (1993). Spirometry reference values for women and men 65 to 85 years of age. Cardiovascular health study. The American Review of Respiratory Disease, 147(1), 125–133. https://doi.org/10.1164/ajrccm/147.1.125.
Article Google Scholar
Ermilov, V. V., & Nesterova, A. A. (2016). β-Amyloidopathy in the pathogenesis of age-related macular degeneration in correlation with neurodegenerative diseases. Advances in Experimental Medicine and Biology, 854, 119–125. https://doi.org/10.1007/978-3-319-17121-0_17.
Article Google Scholar
Esposito, C., Plati, A., Mazzullo, T., Fasoli, G., De Mauri, A., Grosjean, F., Mangione, F., Castoldi, F., Serpieri, N., Cornacchia, F., & Dal Canton, A. (2007). Renal function and functional reserve in healthy elderly individuals. Journal of Nephrology, 20(5), 617–625.
Google Scholar
Factor, S. A., & Weiner, W. J. (Eds.). (2008). Parkinson’s disease: Diagnosis and clinical management (2nd ed.). Demos Medical Publishing, New York.
Google Scholar
Fine, S. L., Berger, J. W., Maguire, M. G., & Ho, A. C. (2000). Age-related macular degeneration. The New England Journal of Medicine, 342(7), 483–492. https://doi.org/10.1056/NEJM200002173420707.
Article Google Scholar
Finegood, D. T., Scaglia, L., & Bonner-Weir, S. (1995). Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes, 44(3), 249–256. https://doi.org/10.2337/diab.44.3.249.
Article Google Scholar
Flanary, B. (2009). Telomeres: Function, shortening, and lengthening. In L. Mancini (Ed.), Telomeres: Function, shortening and lengthening (pp. 379–386). New York: Nova Science Publ Inc.
Google Scholar
Forrester, J. V., Dick, A. D., McMenamin, P., & Lee, W. (1996). The eye: Basic sciences in practice. London: W. B. Saunders Company Ltd..
Google Scholar
Fossel, M. B. (1996). Reversing human aging. New York: William Morrow and Company.
Google Scholar
Fossel, M. B. (2004). Cells, aging and human disease. New York: Oxford University Press.
Google Scholar
Fox, S. I., & Rompolski, K. (2019). Human physiology (15th ed.). New York: McGraw-Hill Education.
Google Scholar
Francis, R. M. (1998). Metabolic bone disease. In R. C. Tallis, H. M. Fillit, & J. C. Brocklehurst (Eds.), Brocklehurst’s textbook of geriatric medicine and gerontology (5th ed., pp. 1137–1154). New York: Churchill Livingstone.
Google Scholar
Frisch, B., Lewis, S. M., Burkhardt, R., & Bartl, R. (1985). Biopsy pathology of bone and marrow. London: Chapman and Hall.
Google Scholar
Fry, R. J., Lesher, S., & Kohn, H. I. (1961). Age effect on cell-transit time in mouse jejunal epithelium. The American Journal of Physiology, 201, 213–216. https://doi.org/10.1152/ajplegacy.1961.201.1.213.
Article Google Scholar
Fuenzalida, M., Lemus, S., Illanes, J., Montiel, E., Acuña, O., & Lemus, D. (2000). Histochemical detection of sugar residues in lizard teeth (Liolaemus gravenhorsti): A lectin-binding study. Biological Research, 33(3–4), 215–226. https://doi.org/10.4067/s0716-97602000000300008.
Article Google Scholar
Fukuda, T., Kikuchi, M., Kurotaki, T., Oyamada, T., Yoshikawa, H., & Yoshikawa, T. (2001). Age-related changes in the testes of horses. Equine Veterinary Journal, 33(1), 20–25. https://doi.org/10.2746/042516401776767449.
Article Google Scholar
Gaete, M., & Tucker, A. S. (2013). Organized emergence of multiple-generations of teeth in snakes is dysregulated by activation of Wnt/Beta-catenin Signalling. PLoS One, 8(9), e74484. https://doi.org/10.1371/journal.pone.0074484.
Article Google Scholar
Galpern, W. R., & Lang, A. E. (2006). Interface between tauopathies and synucleinopathies: A tale of two proteins. Annals of Neurology, 59(3), 449–458. https://doi.org/10.1002/ana.20819.
Article Google Scholar
Geiger, H., & van Zant, G. (2002). The aging of lympho-hematopoietic stem cells. Nature Immunology, 3(4), 329–333. https://doi.org/10.1038/ni0402-329.
Article Google Scholar
Gescheider, G. A., Bolanowski, S. J., Hall, K. L., Hoffman, K. E., & Verrillo, R. T. (1994). The effects of aging on information-processing channels in the sense of touch: I. Absolute sensitivity. Somatosensory & Motor Research, 11(4), 347–357. https://doi.org/10.3109/08990229409028878.
Article Google Scholar
Gilchrest, B. A., Blog, F. B., & Szabo, G. (1969). Effects of aging and chronic sun exposure on melanocytes in human skin. Journal of Investigative Dermatology, 73(2), 141–143. https://doi.org/10.1111/1523-1747.ep12581580.
Article Google Scholar
Gilchrest, B. A., Stoff, J. S., & Soter, N. A. (1982). Chronologic aging alters the response to ultraviolet-induced inflammation in human skin. The Journal of Investigative Dermatology, 79(1), 11–15. https://doi.org/10.1111/1523-1747.ep12510417.
Article Google Scholar
Gilleece, M. H., & Dexter, T. M. (1998). Aging and the blood. In R. C. Tallis, H. M. Fillit, & J. C. Brocklehurst (Eds.), Brocklehurst’s textbook of geriatric medicine and gerontology (5th ed., pp. 1241–1246). New York: Churchill Livingstone.
Google Scholar
Gorelick, P. B. (2004). Risk factors for vascular dementia and Alzheimer disease. Stroke, 35(11 Suppl 1), 2620–2622. https://doi.org/10.1161/01.STR.0000143318.70292.47.
Article Google Scholar
Gouveri, E., Katotomichelakis, M., Gouveris, H., Danielides, V., Maltezos, E., & Papanas, N. (2014). Olfactory dysfunction in type 2 diabetes mellitus: An additional manifestation of microvascular disease? Angiology, 65(10), 869–876. https://doi.org/10.1177/0003319714520956.
Article Google Scholar
Graziadei, P. P. C., & Monti Graziadei, G. A. (1978). Continuous nerve cell renewal in the olfactory system. In M. Jacobson (Ed.), Handbook of sensory physiology (Development of sensory systems) (Vol. IX, pp. 55–83). Berlin/Heidelberg: Springer.
Google Scholar
Griffiths, C. E. M. (1998). Aging of the skin. In R. C. Tallis, H. M. Fillit, & J. C. Brocklehurst (Eds.), Brocklehurst’s textbook of geriatric medicine and gerontology (5th ed., pp. 1293–1298). New York: Churchill Livingstone.
Google Scholar
Grimby, G., Danneskiold-Samsøe, B., Hvid, K., & Saltin, B. (1982). Morphology and enzymatic capacity in arm and leg muscles in 78–81 year old men and women. Acta Physiol Scand, 115(1), 125–134. https://doi.org/10.1111/j.1748-1716.1982.tb07054.x.
Article Google Scholar
Grizzi, F., Di Caro, G., Laghi, L., Hermonat, P., Mazzola, P., Nguyen, D. D., Radhi, S., Figueroa, J. A., Cobos, E., Annoni, G., & Chiriva-Internati, M. (2013). Mast cells and the liver aging process. Immunity & Ageing, 10(1), 9. https://doi.org/10.1186/1742-4933-10-9.
Article Google Scholar
Grove, G. L. (1989). Age-associated changes in human epidermal cell renewal and repair. In A. K. Balin & A. M. Kligman (Eds.), Aging and the skin (pp. 193–204). New York: Raven Press.
Google Scholar
Grzegorczyk, P. B., Jones, S. W., & Mistretta, C. M. (1979). Age related differences in salt-tast acuity. Journal of Gerontology, 34(6), 834–840. https://doi.org/10.1093/geronj/34.6.834.
Article Google Scholar
Guerrier, Y., & Uziel, A. (1979). Clinical aspects of taste disorders. Acta Oto-Laryngologica, 87(3–6), 232–235. https://doi.org/10.3109/00016487909126413.
Article Google Scholar
Gupta, V. B., Rajagopala, M., & Ravishankar, B. (2014). Etiopathogenesis of cataract: An appraisal. Indian Journal of Ophthalmology, 62(2), 103–110. https://doi.org/10.4103/0301-4738.121141.
Article Google Scholar
Halliday, G. M., & Stevens, C. H. (2011). Glia: Initiators and progressors of pathology in Parkinson’s disease. Movement Disorders, 26(1), 6–17. https://doi.org/10.1002/mds.23455.
Article Google Scholar
Handelsman, D. J., & Staraj, S. (1985). Testicular size: The effects of aging, malnutrition, and illness. Journal of Andrology, 6(3), 144–151. https://doi.org/10.1002/j.1939-4640.1985.tb00830.x.
Article Google Scholar
Hao, L. Y., Armanios, M., Strong, M. A., Karim, B., Feldser, D. M., Huso, D., & Greider, C. W. (2005). Short telomeres, even in the presence of telomerase, limit tissue renewal capacity. Cell, 123(6), 1121–1131. https://doi.org/10.1016/j.cell.2005.11.020.
Article Google Scholar
Harada, K., Iwata, M., Kono, N., Koda, W., Shimonishi, T., & Nakanuma, Y. (2000). Distribution of apoptotic cells and expression of apoptosis-related proteins along the intrahepatic biliary tree in normal and non-biliary diseased liver. Histopathology, 37(4), 347–354. https://doi.org/10.1046/j.1365-2559.2000.00982.x.
Article Google Scholar
Harris, M. I., Hadden, W. C., Knowler, W. C., & Bennett, P. H. (1987). Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in U.S. population aged 20-74 yr. Diabetes, 36(4), 523–534. https://doi.org/10.2337/diab.36.4.523.
Article Google Scholar
Hartsock, R. J., Smith, E. B., & Petty, C. S. (1965). Normal variations with aging of the amount of hematopoietic tissue in bone marrow from the anterior iliac crest. A study made from 177 cases of sudden death examined by necropsy. American Journal of Clinical Pathology, 43, 326–331. https://doi.org/10.1093/ajcp/43.4.326.
Article Google Scholar
Hayflick, L. (1977). The cellular basis for biological aging. In C. E. Finch & L. Hayflick (Eds.), Handbook of the biology of aging (pp. 159–186). New York: Van Nostrand Reinhold Co.
Google Scholar
Henchcliffe, C., Dodel, R., & Beal, M. F. (2011). Biomarkers of Parkinson’s disease and Dementia with Lewy bodies. Progress in Neurobiology, 95(4), 601–613. https://doi.org/10.1016/j.pneurobio.2011.09.002.
Article Google Scholar
Henkin, R. I., Graziadei, P. P. G., & Bradley, D. F. (1969). NIH clinical staff conference. The molecular basis of taste and his disorders. Annals of Internal Medicine, 71(4), 791–821. https://doi.org/10.7326/0003-4819-71-4-791.
Article Google Scholar
Héraud, F., Héraud, A., & Harmand, M. F. (2000). Apoptosis in normal and osteoarthritic human articular cartilage. Annals of the Rheumatic Diseases, 59(12), 959–965. https://doi.org/10.1136/ard.59.12.959.
Article Google Scholar
Hill, K., & Hurtado, A. M. (1996). Ache life history. New York: Aldine De Gruyter.
Google Scholar
Hill, J. M., Zalos, G., Halcox, J. P., Schenke, W. H., Waclawiw, M. A., Quyyumi, A. A., & Finkel, T. (2003). Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. The New England Journal of Medicine, 348(7), 593–600. https://doi.org/10.1056/NEJMoa022287.
Article Google Scholar
Huard, J. M., Youngentob, S. L., Goldstein, B. J., Luskin, M. B., & Schwob, J. E. (1998). Adult olfactory epithelium contains multipotent progenitors that give rise to neurons and non-neural cells. The Journal of Comparative Neurology, 400(4), 469–486. https://doi.org/10.1002/(SICI)1096-9861(19981102)400:4<469::AID-CNE3>3.0.CO;2-8.
Article Google Scholar
Iwai, N., Zhou, Z., Roop, D. R., & Behringer, R. R. (2008). Horizontal basal cells are multipotent progenitors in normal and injured adult olfactory epithelium. Stem Cells, 26(5), 1298–1306. https://doi.org/10.1634/stemcells.2007-0891.
Article Google Scholar
Jacobson, M. D., Weil, M., & Raff, M. C. (1997). Programmed cell death in animal development. Cell, 88(3), 347–354. https://doi.org/10.1016/s0092-8674(00)81873-5.
Article Google Scholar
Jankovic, J. (2008). Parkinson’s disease: Clinical features and diagnosis. Journal of Neurology, Neurosurgery, and Psychiatry, 79(4), 368–376. https://doi.org/10.1136/jnnp.2007.131045.
Article Google Scholar
Jassal, V., Fillit, H., & Oreopoulos, D. G. (1998). Aging of the urinary tract. In R. C. Tallis, H. M. Fillit, & J. C. Brocklehurst (Eds.), Brocklehurst’s textbook of geriatric medicine and gerontology (5th ed., pp. 919–924). New York: Churchill Livingstone.
Google Scholar
Jonassaint, N. L., Guo, N., Califano, J. A., Montgomery, E. A., & Armanios, M. (2013). The gastrointestinal manifestations of telomere-mediated disease. Aging Cell, 12(2), 319–323. https://doi.org/10.1111/acel.12041.
Article Google Scholar
Kaeberlein, M., Burtner, C. R., & Kennedy, B. K. (2007). Recent developments in yeast aging. PLoS Genetics, 3(5), e84. https://doi.org/10.1371/journal.pgen.0030084.
Article Google Scholar
Kajstura, J., Leri, A., Finato, N., Di Loreto, C., Beltrami, C. A., & Anversa, P. (1998). Myocyte proliferation in end-stage cardiac failure in humans. Proceedings of the National Academy of Sciences of the United States of America, 95(15), 8801–8805. https://doi.org/10.1073/pnas.95.15.8801.
Article Google Scholar
Katzberg, A. A. (1958). The area of the dermo-epidermal junction in human skin. The Anatomical Record, 131(4), 717–725. https://doi.org/10.1002/ar.1091310408.
Article Google Scholar
Keller, K. M., & Howlett, S. E. (2016). Sex differences in the biology and pathology of the aging heart. The Canadian Journal of Cardiology, 32(9), 1065–1073. https://doi.org/10.1016/j.cjca.2016.03.017.
Article Google Scholar
Kenshalo, D. R. (1986). Somesthetic sensitivity in young and elderly humans. Journal of Gerontology, 41(6), 732–742. https://doi.org/10.1093/geronj/41.6.732.
Article Google Scholar
Kerr, J. F., Wyllie, A. H., & Currie, A. R. (1972). Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. British Journal of Cancer, 26(4), 239–257. https://doi.org/10.1038/bjc.1972.33.
Article Google Scholar
Kim, I. H., Kisseleva, T., & Brenner, D. A. (2015). Aging and liver disease. Current Opinion in Gastroenterology, 31(3), 184–191. https://doi.org/10.1097/MOG.0000000000000176.
Article Google Scholar
Kirkland, J. L., & Tchkonia, T. (2017). Cellular senescence: A translational perspective. eBioMedicine, 21, 21–28. https://doi.org/10.1016/j.ebiom.2017.04.013.
Article Google Scholar
Klein, R., Deng, Y., Klein, B. E., Hyman, L., Seddon, J., Frank, R. N., Wallace, R. B., Hendrix, S. L., Kuppermann, B. D., Langer, R. D., Kuller, L., Brunner, R., et al. (2007). Cardiovascular disease, its risk factors and treatment, and age-related macular degeneration: Women’s health Initiative sight exam ancillary study. American Journal of Ophthalmology, 143(3), 473–483. https://doi.org/10.1016/j.ajo.2006.11.058.
Article Google Scholar
Klein, R., Cruickshanks, K. J., Nash, S. D., Krantz, E. M., Nieto, F. J., Huang, G. H., Pankow, J. S., & Klein, B. E. (2010). The prevalence of age-related macular degeneration and associated risk factors. Archives of Ophthalmology, 128(6), 750–758. https://doi.org/10.1001/archophthalmol.2010.92.
Article Google Scholar
Klitgaard, H., Mantoni, M., Schiaffino, S., Ausoni, S., Gorza, L., Laurent-Winter, C., Schnohr, P., & Saltin, B. (1990). Function. Morphology and protein expression of ageing skeletal muscle: A cross-sectional study of elderly men with different training backgrounds. Acta Physiologica Scandinavica, 140(1), 41–54. https://doi.org/10.1111/j.1748-1716.1990.tb08974.x.
Article Google Scholar
Kubota, K., Shirakura, T., Orui, T., Muratani, M., Maki, T., Tamura, J., & Morita, T. (1991). Changes in the blood cell counts with aging (article in Japanese). Nihon Ronen Igakkai Zasshi, 28(4), 509–514. https://doi.org/10.3143/geriatrics.28.509.
Article Google Scholar
Kydd, W. L., & Daly, C. H. (1982). The biological and mechanical effects of stress on oral mucosa. Journal of Prosthetic Dentistry, 47(3), 317–329. https://doi.org/10.1016/0022-3913(82)90162-7.
Article Google Scholar
Lai, S. W., Liao, K. F., Lin, C. L., Lin, C. C., & Sung, F. C. (2014). Hearing loss may be a non-motor feature of Parkinson’s disease in older people in Taiwan. European Journal of Neurology, 21(5), 752–757. https://doi.org/10.1111/ene.12378.
Article Google Scholar
Laun, P., Bruschi, C. V., Dickinson, J. R., Rinnerthaler, M., Heeren, G., Schwimbersky, R., Rid, R., & Breitenbach, M. (2007). Yeast mother cell-specific ageing, genetic (in)stability, and the somatic mutation theory of ageing. Nucleic Acids Research, 35(22), 7514–7526. https://doi.org/10.1093/nar/gkm919.
Article Google Scholar
Lebrasseur, N. K., Tchkonia, T., & Kirkland, J. L. (2015). Cellular senescence and the biology of aging, disease, and frailty. Nestlé Nutrition Institute Workshop Series, 83, 11–18. https://doi.org/10.1159/000382054.
Article Google Scholar
Lee, H. W., Blasco, M. A., Gottlieb, G. J., Horner, J. W., 2nd, Greider, C. W., & DePinho, R. A. (1998). Essential role of mouse telomerase in highly proliferative organs. Nature, 392(6676), 569–574. https://doi.org/10.1038/33345.
Article Google Scholar
Leri, A., Barlucchi, L., Limana, F., Deptala, A., Darzynkiewicz, Z., Hintze, T. H., Kajstura, J., Nadal-Ginard, B., & Anversa, P. (2001). Telomerase expression and activity are coupled with myocyte proliferation and preservation of telomeric length in the failing heart. Proceedings of the National Academy of Sciences of the United States of America, 98(15), 8626–8631. https://doi.org/10.1073/pnas.151013298.
Article Google Scholar
Lesher, S., & Sacher, G. A. (1968). Effects of age on cell proliferation in mouse duodenal crypts. Experimental Gerontology, 3(3), 211–217. https://doi.org/10.1016/0531-5565(68)90004-1.
Article Google Scholar
Lesher, S., Fry, R. J., & Kohn, H. I. (1961). Influence of age on transit time of cells of mouse intestinal epithelium. I. Duodenum. Laboratory Investigation, 10, 291–300.
Google Scholar
Leung, C. T., Coulombe, P. A., & Reed, R. R. (2007). Contribution of olfactory neural stem cells to tissue maintenance and regeneration. Nature Neuroscience, 10(6), 720–726. https://doi.org/10.1038/nn1882.
Article Google Scholar
Lexell, J., Taylor, C. C., & Sjöström, M. (1988). What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men. Journal of the Neurological Sciences, 84(2–3), 275–294. https://doi.org/10.1016/0022-510x(88)90132-3.
Article Google Scholar
Libertini, G. (2009a). The role of telomere-telomerase system in age-related fitness decline, a tameable process. In L. Mancini (Ed.), Telomeres: Function, shortening and lengthening (pp. 77–132). New York: Nova Science Publ.
Google Scholar
Libertini, G. (2009b). Prospects of a longer life span beyond the beneficial effects of a healthy lifestyle. In J. V. Bentely & M. A. Keller (Eds.), Handbook on longevity: Genetics, diet and disease (pp. 35–95). New York: Nova Science Publ.
Google Scholar
Libertini, G. (2012). Classification of Phenoptotic phenomena. Biochem (Mosc), 77(7), 707–715. https://doi.org/10.1134/S0006297912070024.
Article Google Scholar
Libertini, G. (2015a). Non-programmed versus programmed aging paradigm. Current Aging Science, 8(1), 56–68. https://doi.org/10.2174/1874609808666150422111623.
Article Google Scholar
Libertini, G. (2015b). Phylogeny of aging and related Phenoptotic phenomena. Biochem (Mosc), 80(12), 1529–1546. https://doi.org/10.1134/S0006297915120019.
Article Google Scholar
Libertini, G. (2017). The feasibility and necessity of a revolution in Geriatric medicine. OBM Geriatrics, 1(2). https://doi.org/10.21926/obm.geriat.1702002
Libertini, G. (2018). Programmed aging paradigm and aging of perennial neurons. In S. I. Ahmad (Ed.), Aging. exploring a complex phenomenon (pp. 91–116). Boca Raton: CRC Press/Taylor & Francis Group.
Google Scholar
Libertini, G., & Ferrara, N. (2016). Aging of perennial cells and organ parts according to the programmed aging paradigm. Age (Dordrecht, Netherlands), 38(2), 35. https://doi.org/10.1007/s11357-016-9895-0.
Article Google Scholar
Lim, J. Y. (2016). Therapeutic potential of eccentric exercises for age-related muscle atrophy. Integrative Medicine Research, 5(3), 176–181. https://doi.org/10.1016/j.imr.2016.06.003.
Article Google Scholar
Lin, F. R., Metter, E. J., O’Brien, R. J., Resnick, S. M., Zonderman, A. B., & Ferrucci, L. (2011). Hearing loss and incident dementia. Archives of Neurology, 68(2), 214–220. https://doi.org/10.1001/archneurol.2010.362.
Article Google Scholar
Lin, F. R., Thorpe, R., Gordon-Salant, S., & Ferrucci, L. (2011). Hearing loss prevalence and risk factors among older adults in the United States. The Journals of Gerontology, Series A, Biological Sciences and Medical Sciences, 66A(5), 582–590. https://doi.org/10.1093/gerona/glr002.
Article Google Scholar
Liu, P. I., Takanari, H., Yatani, R., & Nelson, G. (1989). Comparative studies of bone marrow from the United States and Japan. Annals of Clinical & Laboratory Science, 19(5), 345–351.
Google Scholar
López de Silanes, I., Graña, O., De Bonis, M. L., Dominguez, O., Pisano, D. G., & Blasco, M. A. (2014). Identification of TERRA locus unveils a telomere protection role through association to nearly all chromosomes. Nature Communications, 5, 4723. https://doi.org/10.1038/ncomms5723.
Article Google Scholar
Lynch, M. P., Nawaz, S., & Gerschenson, L. E. (1986). Evidence for soluble factors regulating cell death and cell proliferation in primary cultures of rabbit endometrial cells grown on collagen. Proceedings of the National Academy of Sciences of the United States of America, 83(13), 4784–4788. https://doi.org/10.1073/pnas.83.13.4784.
Article Google Scholar
MacGregor, R. R., & Shalit, M. (1990). Neutrophil function in healthy elderly subjects. Journal of Gerontology, 45(2), M55–M60. https://doi.org/10.1093/geronj/45.2.m55.
Article Google Scholar
Maier, E. C., Saxena, A., Alsina, B., Bronner, M. E., & Whitfielda, T. T. (2014). Sensational placodes: Neurogenesis in the otic and olfactory systems. Developmental Biology, 389(1), 50–67. https://doi.org/10.1016/j.ydbio.2014.01.023.
Article Google Scholar
Marchesini, G., Bua, V., Brunori, A., Bianchi, G., Pisi, P., Fabbri, A., Zoli, M., & Pisi, E. (1988). Galactose elimination capacity and liver volume in aging man. Hepatology, 8(5), 1079–1083. https://doi.org/10.1002/hep.1840080516.
Article Google Scholar
Martin, G. M., & Oshima, J. (2000). Lessons from human progeroid syndromes. Nature, 408(6809), 263–266. https://doi.org/10.1038/35041705.
Article Google Scholar
Martinez, C. H., Diaz, A. A., Meldrum, C., Curtis, J. L., Cooper, C. B., Pirozzi, C., Kanner, R. E., Paine, R., 3rd, Woodruff, P. G., Bleecker, E. R., Hansel, N. N., Barr, R. G., SPIROMICS Investigators, et al. (2017). Age and small airway imaging abnormalities in subjects with and without airflow obstruction in SPIROMICS. American Journal of Respiratory and Critical Care Medicine, 195(4), 464–472. https://doi.org/10.1164/rccm.201604-0871OC.
Article Google Scholar
McKeith, I. (2004). Dementia with Lewy bodies. Dialogues in Clinical Neuroscience, 6(3), 333–341. www.ncbi.nlm.nih.gov/pmc/articles/PMC3181810/.
Article Google Scholar
McLachlan, M. S. F. (1978). The ageing kidney. The Lancet, 312(8081), 143–146. www.sciencedirect.com/science/article/pii/S0140673678915222.
Article Google Scholar
Medh, R. D., & Thompson, E. B. (2000). Hormonal regulation of physiological cell turnover and apoptosis. Cell and Tissue Research, 301(1), 101–124. https://doi.org/10.1007/s004419900159.
Article Google Scholar
Meunier, P., Aaron, J., Edouard, C., & Vignon, G. (1971). Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. A quantitative study of 84 iliac bone biopsies. Clinical Orthopaedics and Related Research, 80, 147–154.
Article Google Scholar
Migheli, A., Mongini, T., Doriguzzi, C., Chiadò-Piat, L., Piva, R., Ugo, I., & Palmucci, L. (1997). Muscle apoptosis in humans occurs in normal and denervated muscle, but not in myotonic dystrophy, dystrophinopathies or inflammatory disease. Neurogenetics, 1(2), 81–87. https://doi.org/10.1007/s100480050012.
Article Google Scholar
Morales, I., Sanchez, A., Rodriguez-Sabate, C., & Rodriguez, M. (2015). The degeneration of dopaminergic synapses in Parkinson’s disease: A selective animal model. Behavioural Brain Research, 289, 19–28. https://doi.org/10.1016/j.bbr.2015.04.019.
Article Google Scholar
Mościcki, E. K., Elkins, E. F., Baum, H. M., & McNamara, P. M. (1985). Hearing loss in the elderly: An epidemiologic study of the Framingham heart study cohort. Ear and Hearing, 6(4), 184–190. https://europepmc.org/article/med/4043571.
Article Google Scholar
Motlagh, M., & Geetha, R. (2019). Physiology, accommodation. Treasure Island: StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK542189/.
Google Scholar
Murasko, D. M., Nelson, B. J., Silver, R., Matour, D., & Kaye, D. (1986). Immunologic response in an elderly population with a mean age of 85. The American Journal of Medicine, 81(4), 612–618. https://doi.org/10.1016/0002-9343(86)90546-2.
Article Google Scholar
Murphy, R. C. (1925). Bird Islands of Peru. New York: GP Putnam’s Sons.
Google Scholar
Murphy, C. (1987). Ageing and chemosensory perception. In D. B. Ferguson (Ed.), The ageing mouth (pp. 135–150). Basel: Karger.
Google Scholar
Murphy, C., Schubert, C. R., Cruickshanks, K. J., Klein, B. E., Klein, R., & Nondahl, D. M. (2002). Prevalence of olfactory impairment in older adults. JAMA, 288(18), 2307–2312. https://doi.org/10.1001/jama.288.18.2307.
Article Google Scholar
Mutch, W. J., & Inglis, F. G. (1998). Parkinsonism and other movement disorders. In R. C. Tallis, H. M. Fillit, & J. C. Brocklehurst (Eds.), Brocklehurst’s textbook of geriatric medicine and gerontology (5th ed., pp. 565–594). New York: Churchill Livingstone.
Google Scholar
Norwood, O. T. (2001). Incidence of female androgenetic alopecia (female pattern alopecia). Dermatologic Surgery, 27(1), 53–54. https://insights.ovid.com/pubmed?pmid=11231244.
Google Scholar
Nuytemans, K., Theuns, J., Cruts, M., & Van Broeckhoven, C. (2010). Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: A mutation update. Human Mutation, 31(7), 763–780. https://doi.org/10.1002/humu.21277.
Article Google Scholar
Obeso, J. A., Rodríguez-Oroz, M. C., Benitez-Temino, B., Blesa, F. J., Guridi, J., Marin, C., & Rodriguez, M. (2008). Functional organization of the basal ganglia: Therapeutic implications for Parkinson’s disease. Movement Disorders, 23(Suppl 3), S548–S559. https://doi.org/10.1002/mds.22062.
Article Google Scholar
Obeso, J. A., Rodriguez-Oroz, M. C., Goetz, C. G., Marin, C., Kordower, J. H., Rodriguez, M., Hirsch, E. C., Farrer, M., Schapira, A. H., & Halliday, G. (2010). Missing pieces in the Parkinson’s disease puzzle. Nature Medicine, 16(6), 653–661. https://doi.org/10.1038/nm.2165.
Article Google Scholar
Olivetti, G., Melissari, M., Capasso, J. M., & Anversa, P. (1991). Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy. Circulation Research, 68(6), 1560–1568. https://doi.org/10.1161/01.res.68.6.1560.
Article Google Scholar
Olivetti, G., Giordano, G., Corradi, D., Melissari, M., Lagrasta, C., Gambert, S. R., & Anversa, P. (1995). Gender differences and aging: Effects on the human heart. Journal of the American College of Cardiology, 26(4), 1068–1079. https://doi.org/10.1016/0735-1097(95)00282-8.
Article Google Scholar
Paik, J. H., Yoon, J. B., Sim, W. Y., Kim, B. S., & Kim, N. I. (2001). The prevalence and types of androgenetic alopecia in Korean men and women. The British Journal of Dermatology, 145(1), 95–99. https://doi.org/10.1046/j.1365-2133.2001.04289.x.
Article Google Scholar
Pescosolido, N., Barbato, A., Giannotti, R., Komaiha, C., & Lenarduzzi, F. (2016). Age-related changes in the kinetics of human lenses: prevention of the cataract. International Journal of Ophthalmology, 9(10), 1506–1517. https://doi.org/10.18240/ijo.2016.10.23.
Article Google Scholar
Petrash, J. M. (2013). Aging and age-related diseases of the ocular lens and vitreous body. Investigative Ophthalmology & Visual Science, 54(14), ORSF54-9. https://doi.org/10.1167/iovs.13-12940.
Phillips, S. K., Bruce, S. A., Newton, D., & Woledge, R. C. (1992). The weakness of old age is not due to failure of muscle activation. Journal of Gerontology, 47(2), M45–M49. https://doi.org/10.1093/geronj/47.2.m45.
Article Google Scholar
Pollack, M., & Leeuwenburgh, C. (2001). Apoptosis and aging: Role of the mitochondria. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 56(11), B475–B482. https://doi.org/10.1093/gerona/56.11.b475.
Article Google Scholar
Pontèn, J., Stein, W. D., & Shall, S. (1983). A quantitative analysis of the aging of human glial cells in culture. Journal of Cellular Physiology, 117(3), 342–352. https://doi.org/10.1002/jcp.1041170309.
Article Google Scholar
Potvin, A. R., Syndulko, K., Tourtellotte, W. W., Lemmon, J. A., & Potvin, J. H. (1980). Human neurologic function and the aging process. Journal of the American Geriatrics Society, 28(1), 1–9. https://doi.org/10.1111/j.1532-5415.1980.tb00115.x.
Article Google Scholar
Price, W. A. (1939). Nutrition and physical degeneration. New York/London: Paul B. Hoeber [Other editions in 1945, 1970, 1989, 1997, 2004, 2006, 2008, 2011; the last edition has been used].
Google Scholar
Pringsheim, T., Jette, N., Frolkis, A., & Steeves, T. D. (2014). The prevalence of Parkinson’s disease: A systematic review and meta-analysis. Movement Disorders, 29(13), 1583–1590. https://doi.org/10.1002/mds.25945.
Article Google Scholar
Prins, J. B., & O’Rahilly, S. (1997). Regulation of adipose cell number in man. Clinical Science (London, England), 92(1), 3–11. https://doi.org/10.1042/cs0920003.
Article Google Scholar
Qiu, W. Q., Walsh, D. M., Ye, Z., Vekrellis, K., Zhang, J., Podlisny, M. B., Rosner, M. R., Safavi, A., Hersh, L. B., & Selkoe, D. J. (1998). Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. The Journal of Biological Chemistry, 273(49), 32730–32738. https://doi.org/10.1074/jbc.273.49.32730.
Article Google Scholar
Ramos, P. M., & Miot, H. A. (2015). Female pattern hair loss: A clinical and pathophysiological review. Anais Brasileiros de Dermatologia, 90(4), 529–543. https://doi.org/10.1590/abd1806-4841.20153370.
Article Google Scholar
Reed, J. C. (1999). Dysregulation of apoptosis in cancer. Journal of Clinical Oncology, 17(9), 2941–2953. https://doi.org/10.1200/JCO.1999.17.9.2941.
Article Google Scholar
Reinus, J. F., & Brandt, L. J. (1998). The upper gastrointestinal tract. In Brocklehurst’s textbook of geriatric medicine and gerontology (5th ed., pp. 803–826). New York: Churchill Livingstone.
Google Scholar
Reitmeir, P., Linkohr, B., Heier, M., Molnos, S., Strobl, R., Schulz, H., Breier, M., Faus, T., Küster, D. M., Wulff, A., Grallert, H., Grill, E., et al. (2017). Common eye diseases in older adults of southern Germany: Results from the KORA-age study. Age and Ageing, 46(3), 481–486. https://doi.org/10.1093/ageing/afw234.
Article Google Scholar
Richardson, B. R., Allan, D. S., & Le, Y. (2014). Greater organ involution in highly proliferative tissues associated with the early onset and acceleration of ageing in humans. Experimental Gerontology, 55, 80–91. https://doi.org/10.1016/j.exger.2014.03.015.
Article Google Scholar
Rosendorff, C., Beeri, M. S., & Silverman, J. M. (2007). Cardiovascular risk factors for Alzheimer’s disease. The American Journal of Geriatric Cardiology, 16(3), 143–149. https://doi.org/10.1111/j.1076-7460.2007.06696.x.
Article Google Scholar
Rudnicka, A. R., Jarrar, Z., Wormald, R., Cook, D. G., Fletcher, A., & Owen, C. G. (2012). Age and gender variations in age-related macular degeneration prevalence in populations of European ancestry: A meta-analysis. Ophthalmology, 119(3), 571–580. https://doi.org/10.1016/j.ophtha.2011.09.027.
Article Google Scholar
Rutherford, O. M., & Jones, D. A. (1992). The relationship of muscle and bone loss and activity levels with age in women. Age and Ageing, 21(4), 286–293. https://doi.org/10.1093/ageing/21.4.286.
Article Google Scholar
Samii, A., Nutt, J. G., & Ransom, B. R. (2004). Parkinson’s disease. Lancet, 363(9423), 1783–1793. https://doi.org/10.1016/S0140-6736(04)16305-8.
Article Google Scholar
Sanderson, W. C., & Scherbov, S. (2005). Average remaining lifetimes can increase as human populations age. Nature, 435(7043), 811–813. https://doi.org/10.1038/nature03593.
Article Google Scholar
Schludermann, E., & Zubek, J. P. (1962). Effect of age on pain sensitivity. Perceptual & Motor Skills Research Exchange, 14(2), 295–301.
Article Google Scholar
Schubert, C. R., Cruickshanks, K. J., Fischer, M. E., Huang, G. H., Klein, B. E., Klein, R., Pankow, J. S., & Nondahl, D. M. (2012). Olfactory impairment in an adult population: The Beaver Dam offspring study. Chemical Senses, 37(4), 325–334. https://doi.org/10.1093/chemse/bjr102.
Article Google Scholar
Schulz-Schaeffer, W. J. (2010). The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson’s disease and Parkinson’s disease dementia. Acta Neuropathologica, 120(2), 131–143. https://doi.org/10.1007/s00401-010-0711-0.
Article Google Scholar
Schwab, R., Hausman, P. B., Rinnooy-Kan, E., & Weksler, M. E. (1985). Immunological studies of ageing. X. Impaired T lymphocytes and normal monocyte response from elderly humans to the mitogenic antibodies OKT3 and Leu 4. Immunology, 55(4), 677–684. www.ncbi.nlm.nih.gov/pmc/articles/PMC1453768/.
Google Scholar
Scott, J. (1986). Structure and function in ageing human salivary glands. Gerodontology, 5(3), 149–158. https://doi.org/10.1111/j.1741-2358.1986.tb00062.x.
Article Google Scholar
Scott, J., Valentine, J. A., St Hill, C. A., & Balasooriya, B. A. (1983). A quantitative histological analysis of the effects of age and sex on human lingual epithelium. Journal de Biologie Buccale, 11(4), 303–315.
Google Scholar
Seale, P., Asakura, A., & Rudnicki, M. A. (2001). The potential of muscle stem cells. Developmental Cell, 1(3), 333–342. https://doi.org/10.1016/s1534-5807(01)00049-1.
Article Google Scholar
Segel, M., Neumann, B., Hill, M. F. E., Weber, I. P., Viscomi, C., Zhao, C., Young, A., Agley, C. C., Thompson, A. J., Gonzalez, G. A., Sharma, A., Holmqvist, S., et al. (2019). Niche stiffness underlies the ageing of central nervous system progenitor cells. Nature, 573(7772), 130–134. https://doi.org/10.1038/s41586-019-1484-9.
Article Google Scholar
Sergeyenko, Y., Lall, K., Liberman, M. C., & Kujawa, S. G. (2013). Age-related cochlear synaptopathy: An early-onset contributor to auditory functional decline. The Journal of Neuroscience, 33(34), 13686–13694. https://doi.org/10.1523/JNEUROSCI.1783-13.2013.
Article Google Scholar
Shapiro, J. (2007). Clinical practice. Hair loss in women. The New England Journal of Medicine, 357(16), 1620–1630. https://doi.org/10.1056/NEJMcp072110.
Article Google Scholar
Shoshani, J. (2000). Elephants: Majestic creatures of the wild. New York: Checkmark Books.
Google Scholar
Sim, F. J., Zhao, C., Penderis, J., & Franklin, R. J. M. (2002). The age-related decrease in CNS Remyelination efficiency is attributable to an impairment of both oligodendrocyte progenitor recruitment and differentiation. The Journal of Neuroscience, 22(7), 2451–2459. 20026217.
Article Google Scholar
Sinclair, A. J., & Croxson, S. C. M. (1998). Diabete mellitus in the older adult. In R. C. Tallis, H. M. Fillit, & J. C. Brocklehurst (Eds.), Brocklehurst’s textbook of geriatric medicine and gerontology (5th ed., pp. 1051–1071). New York: Churchill Livingstone.
Google Scholar
Single, G., Dickman, C. R., & MacDonald, D. W. (2001). Rodents. In D. W. MacDonald (Ed.), The new encyclopedia of mammals (pp. 578–587). Oxford: Oxford University Press.
Google Scholar
Sözen, T., Özışık, L., & Başaran, N. Ç. (2017). An overview and management of osteoporosis. European Journal of Rheumatology, 4(1), 46–56. https://doi.org/10.5152/eurjrheum.2016.048.
Article Google Scholar
Sparrow, J. R. (2003). Therapy for macular degeneration: Insights from acne. Proceedings of the National Academy of Sciences of the United States of America, 100(8), 4353–4354. https://doi.org/10.1073/pnas.1031478100.
Article Google Scholar
Spelsberg, T. C., Subramaniam, M., Riggs, B. L., & Khosla, S. (1999). The actions and interactions of sex steroids and growth factors/cytokines on the skeleton. Molecular Endocrinology, 13(6), 819–828. https://doi.org/10.1210/mend.13.6.0299.
Article Google Scholar
Steenman, M., & Lande, G. (2017). Cardiac aging and heart disease in humans. Biophysical Reviews, 9(2), 131–137. https://doi.org/10.1007/s12551-017-0255-9.
Article Google Scholar
Sturm, E., & Stefanova, N. (2014). Multiple system atrophy: Genetic or epigenetic? Experimental Neurobiology, 23(4), 277–291. https://doi.org/10.5607/en.2014.23.4.277.
Article Google Scholar
Su, J. B. (2015). Vascular endothelial dysfunction and pharmacological treatment. World Journal of Cardiology, 7(11), 719–741. https://doi.org/10.4330/wjc.v7.i11.719.
Article Google Scholar
Sutherland, L. M., Edwards, Y. S., & Murray, A. W. (2001). Alveolar type II cell apoptosis. Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology, 129(1), 267–285. https://doi.org/10.1016/s1095-6433(01)00323-3.
Article Google Scholar
Takubo, K., Aida, J., Izumiyama-Shimomura, N., Ishikawa, N., Sawabe, M., Kurabayashi, R., Shiraishi, H., Arai, T., & Nakamura, K.-I. (2010). Changes of telomere length with aging. Geriatrics & Gerontology International, 10(Suppl 1), S197–S206. https://doi.org/10.1111/j.1447-0594.2010.00605.x.
Article Google Scholar
Tallis, R. C., Fillit, H. M., & Brocklehurst, J. C. (Eds.). (1998). Brocklehurst’s textbook of geriatric medicine and gerontology (5th ed.). Churchill Livingstone: New York.
Google Scholar
Tassin, J., Malaise, E., & Courtois, Y. (1979). Human lens cells have an in vitro proliferative capacity inversely proportional to the donor age. Experimental Cell Research, 123(2), 388–392. https://doi.org/10.1016/0014-4827(79)90483-x.
Article Google Scholar
Tchkonia, T., Zhu, Y., van Deursen, J., Campisi, J., & Kirkland, J. L. (2013). Cellular senescence and the senescent secretory phenotype: Therapeutic opportunities. The Journal of Clinical Investigation, 123(3), 966–972. https://doi.org/10.1172/JCI64098.
Article Google Scholar
Thornbury, J. M., & Mistretta, C. M. (1981). Tactile sensitivity as a function of age. Journal of Gerontology, 36(1), 34–39. https://doi.org/10.1093/geronj/36.1.34.
Article Google Scholar
Tyner, S. D., Venkatachalam, S., Choi, J., Jones, S., Ghebranious, N., Igelmann, H., Lu, X., Soron, G., Cooper, B., Brayton, C., Park, S. H., Thompson, T., et al. (2002). p53 mutant mice that display early ageing-associated phenotypes. Nature, 415(6867), 45–53. https://doi.org/10.1038/415045a.
Article Google Scholar
Urbanek, K., Quaini, F., Tasca, G., Torella, D., Castaldo, C., Nadal-Ginard, B., Leri, A., Kajstura, J., Quaini, E., & Anversa, P. (2003). Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy. Proceedings of the National Academy of Sciences of the United States of America, 100(18), 10440–10445. https://doi.org/10.1073/pnas.1832855100.
Article Google Scholar
Urbanek, K., Torella, D., Sheikh, F., De Angelis, A., Nurzynska, D., Silvestri, F., Beltrami, C. A., Bussani, R., Beltrami, A. P., Quaini, F., Bolli, R., Leri, A., et al. (2005). Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure. Proceedings of the National Academy of Sciences of the United States of America, 102(24), 8692–8697. https://doi.org/10.1073/pnas.0500169102.
Article Google Scholar
Vandervoort, A. A., & McComas, A. J. (1986). Contractile changes in opposing muscles of the human ankle joint with aging. Journal of Applied Physiology, 61(1), 361–367. https://doi.org/10.1152/jappl.1986.61.1.361.
Article Google Scholar
Vaziri, H. (1998). Extension of life span in normal human cells by telomerase activation: A revolution in cultural senescence. Journal of Anti-Aging Medicine, 1, 125–130. https://doi.org/10.1089/rej.1.1998.1.125.
Article Google Scholar
Vaziri, H., & Benchimol, S. (1998). Reconstitution of telomerase activity in normal cells leads to elongation of telomeres and extended replicative life span. Current Biology, 8(5), 279–282. https://doi.org/10.1016/s0960-9822(98)70109-5.
Article Google Scholar
Vekrellis, K., Ye, Z., Qiu, W. Q., Walsh, D., Hartley, D., Chesneau, V., Rosner, M. R., & Selkoe, D. J. (2000). Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. The Journal of Neuroscience, 20(5), 1657–1665.
Article Google Scholar
Verbeken, E. K., Cauberghs, M., Mertens, I., Clement, J., Lauweryns, J. M., & Van de Woestijne, K. P. (1992). The senile lung. Comparison with normal and emphysematous lungs. 1. Structural aspects. Chest, 101(3), 793–799. https://doi.org/10.1378/chest.101.3.793.
Article Google Scholar
Vitale, C., Marcelli, V., Allocca, R., Santangelo, G., Riccardi, P., Erro, R., Amboni, M., Pellecchia, M. T., Cozzolino, A., Longo, K., Picillo, M., Moccia, M., et al. (2012). Hearing impairment in Parkinson’s disease: Expanding the nonmotor phenotype. Movement Disorders, 27(12), 1530–1535. https://doi.org/10.1002/mds.25149.
Article Google Scholar
Vogel, T., Benetos, A., Verreault, R., Kaltenbach, G., Kiesmann, M., & Berthel, M. (2006). Risk factors for Alzheimer: Towards prevention? (article in French). Presse Médicale, 35(9 Pt 2), 1309–1316. https://doi.org/10.1016/s0755-4982(06)74810-2.
Article Google Scholar
von Zglinicki, T., Serra, V., Lorenz, M., Saretzki, G., Lenzen-Grossimlighaus, R., Gessner, R., Risch, A., & Steinhagen-Thiessen, E. (2000). Short telomeres in patients with vascular dementia: An indicator of low antioxidative capacity and a possible risk factor? Laboratory Investigation, 80(11), 1739–1747. https://doi.org/10.1038/labinvest.3780184.
Article Google Scholar
Wakabayashi, H., Nishiyama, Y., Ushiyama, T., Maeba, T., & Maeta, H. (2002). Evaluation of the effect of age on functioning hepatocyte mass and liver blood flow using liver scintigraphy in preoperative estimations for surgical patients: Comparison with CT volumetry. The Journal of Surgical Research, 106(2), 246–253. https://doi.org/10.1006/jsre.2002.6462.
Article Google Scholar
Wang, T. L., Zhou, C., Shen, Y. W., Wang, X. Y., Ding, X. L., Tian, S., Liu, Y., Peng, G. H., Xue, S. Q., Zhou, J. E., Wang, R. L., Meng, X. M., et al. (2010). Prevalence of androgenetic alopecia in China: A community-based study in six cities. The British Journal of Dermatology, 162(4), 843–847. https://doi.org/10.1111/j.1365-2133.2010.09640.x.
Article Google Scholar
Watanabe, T., & Tanaka, Y. (1982). Age-related alterations in the size of human epatocytes: Study of mononuclear and binucleate cells. Virchows Archiv B Cell Pathology Including Molecular Pathology, 39(1), 9–20. https://doi.org/10.1007/bf02892832.
Article Google Scholar
Watt, F. M., Lo Celso, C., & Silva-Vargas, V. (2006). Epidermal stem cells: An update. Current Opinion in Genetics & Development, 16(5), 518–524. https://doi.org/10.1016/j.gde.2006.08.006.
Article Google Scholar
Webster, S. G. P. (1978). The gastrointestinal system – C. the pancreas and the small bowel. In J. C. Brocklehurst (Ed.), Textbook of geriatric medicine and gerontology (2nd ed., pp. 358–368). New York: Churchill Livingstone.
Google Scholar
Webster, C., & Blau, H. M. (1990). Accelerated age-related decline in replicative life-span of Duchenne muscular dystrophy myoblasts: Implications for cell and gene therapy. Somatic Cell and Molecular Genetics, 16(6), 557–565. https://doi.org/10.1007/bf01233096.
Article Google Scholar
Webster, S. G. P., & Leeming, J. T. (1975). The appearance of the small bowel mucosa in old age. Age and Ageing, 4(3), 168–174. https://doi.org/10.1093/ageing/4.3.168.
Article Google Scholar
Weinstein, J. R., & Anderson, S. (2010). The aging kidney: Physiological changes. Advances in Chronic Kidney Disease, 17(4), 302–307. https://doi.org/10.1053/j.ackd.2010.05.002.
Article Google Scholar
Weir, M. R. (2007). Microalbuminuria and cardiovascular disease. Clinical Journal of the American Society of Nephrology, 2(3), 581–590. https://doi.org/10.2215/CJN.03190906.
Article Google Scholar
Werner, N., Kosiol, S., Schiegl, T., Ahlers, P., Walenta, K., Link, A., Böhm, M., & Nickenig, G. (2005). Circulating endothelial progenitor cells and cardiovascular outcomes. The New England Journal of Medicine, 353(10), 999–1007. https://doi.org/10.1056/NEJMoa043814.
Article Google Scholar
Williams, R. W., & Herrup, K. (1988). The control of neuron number. Annual Review of Neuroscience, 11(1), 423–453. https://doi.org/10.1146/annurev.ne.11.030188.002231.
Article Google Scholar
Wilson, P. W., Castelli, W. P., & Kannel, W. B. (1987). Coronary risk prediction in adults (the Framingham Heart Study). The American Journal of Cardiology, 59(14), 91–4G. https://doi.org/10.1016/0002-9149(87)90165-2 [Erratum, Am J Cardiol, 1987, 60(13):A11.]
Wong, A. C., & Ryan, A. F. (2015). Mechanisms of sensorineural cell damage, death and survival in the cochlea. Frontiers in Aging Neuroscience, 7, 58. https://doi.org/10.3389/fnagi.2015.00058.
Article Google Scholar
Wright, J. R., Jr., Yates, A. J., Sharma, H. M., Shim, C., Tigner, R. L., & Thibert, P. (1982). Testicular atrophy in the spontaneously diabetic BB Wistar rat. The American Journal of Pathology, 108(1), 72–79.
Google Scholar
Wu, P., Wu, X., Jiang, T.-X., Elsey, R. M., Temple, B. L., Divers, S. J., Glenn, T. C., Yuan, K., Chen, M. H., Widelitz, R. B., & Chuon, C. M. (2013). Specialized stem cell niche enables repetitive renewal of alligator teeth. Proceedings of the National Academy of Sciences of the United States of America, 110(22), E2009–E2018. https://doi.org/10.1073/pnas.1213202110.
Article Google Scholar
Wyllie, A. H., Kerr, J. F. R., & Currie, A. R. (1980). Cell death: The significance of apoptosis. International Review of Cytology, 68, 251–306. https://doi.org/10.1016/s0074-7696(08)62312-8.
Article Google Scholar
Wynne, H. A., Cope, L. H., Mutch, E., Rawlins, M. D., Woodhouse, K. W., & James, O. F. (1989). The effect of age upon liver volume and apparent liver blood flow in healthy man. Hepatology, 9(2), 297–301. https://doi.org/10.1002/hep.1840090222.
Article Google Scholar
Xia, S. J., Xu, C. X., Tang, X. D., Wang, W. Z., & Du, D. L. (2001). Apoptosis and hormonal milieu in ductal system of normal prostate and benign prostatic hyperplasia. Asian Journal of Andrology, 3(2), 131–134.
Google Scholar
Yan, D., Zhu, Y., Walsh, T., Xie, D., Yuan, H., Sirmaci, A., Fujikawa, T., Wong, A. C., Loh, T. L., Du, L., Grati, M., Vlajkovic, S. M., et al. (2013). Mutation of the ATP-gated P2X2 receptor leads to progressive hearing loss and increased susceptibility to noise. Proceedings of the National Academy of Sciences of the United States of America, 110(6), 2228–2233. https://doi.org/10.1073/pnas.1222285110.
Article Google Scholar
Yao, S. C., Hart, A. D., & Terzella, M. J. (2013). An evidence-based osteopathic approach to Parkinson disease. Osteopathic Family Physician, 5(3), 96–101. https://doi.org/10.1016/j.osfp.2013.01.003.
Article Google Scholar
Young, A., Stokes, M., & Crowe, M. (1984). Size and strength of the quadriceps muscles of old and young women. European Journal of Clinical Investigation, 14(4), 282–287. https://doi.org/10.1111/j.1365-2362.1984.tb01182.x.
Article Google Scholar
Young, A., Stokes, M., & Crowe, M. (1985). The size and strength of the quadriceps muscles of old and young men. Clinical Physiology, 5(2), 145–154. https://doi.org/10.1111/j.1475-097x.1985.tb00590.x.
Article Google Scholar
Zhan, W., Cruickshanks, K. J., Klein, B. E., Klein, R., Huang, G. H., Pankow, J. S., Gangnon, R. E., & Tweed, T. S. (2010). Generational differences in the prevalence of hearing impairment in older adults. American Journal of Epidemiology, 171(2), 260–266. https://doi.org/10.1093/aje/kwp370.
Article Google Scholar

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ASL NA2 Nord, Italian Health National System, Frattamaggiore, Napoli, Italy
Giacinto Libertini
Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy
Graziamaria Corbi
Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, Italy
Valeria Conti
M.M. Shemyakin–Yu.A. Ovchinnikov, Institute of Bioorganic Chemistry, Moscow, Russia
Olga Shubernetskaya
Department of Transnational Medical Sciences, University of Naples Federico II, Naples, Italy
Nicola Ferrara

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Libertini, G., Corbi, G., Conti, V., Shubernetskaya, O., Ferrara, N. (2021). Aging in the Human Species. In: Evolutionary Gerontology and Geriatrics. Advances in Studies of Aging and Health, vol 2. Springer, Cham. https://doi.org/10.1007/978-3-030-73774-0_6

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