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Morphological Variants of Invasive Urothelial Carcinoma

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Urinary Bladder Pathology

Abstract

Urothelial carcinomas exhibit a wide range of morphological variations and various molecular alterations. Many of these variants have significant prognosis and therapeutic implications. The variants/classification has been revised in the 2016 World Health Organization (WHO) classification of tumor of the urinary system and male genital organs. In this chapter, the morphological features, diagnostic criteria and pitfalls, differential diagnoses, immunoprofile, molecular alterations, and clinical and prognostic implications for the common variants of invasive urothelial carcinoma will be reviewed. Rare variants and entities that are not included in the current WHO classification will also be discussed briefly.

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Authors and Affiliations

  1. Department of Pathology, New York University Langone Health, New York, NY, USA

    Kyung En Park & Fang-Ming Deng

  2. Lab Medicine and Pathology, Mayo Clinic Florida, Jacksonville, FL, USA

    Qihui “Jim” Zhai

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  2. Qihui “Jim” Zhai
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  1. Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, USA

    Haijun Zhou

  2. Department of Pathology, MD Anderson Cancer Center, Houston, TX, USA

    Charles C. Guo

  3. Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, USA

    Jae Y. Ro

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Park, K.E., Zhai, Q.“., Deng, FM. (2021). Morphological Variants of Invasive Urothelial Carcinoma. In: Zhou, H., Guo, C.C., Ro, J.Y. (eds) Urinary Bladder Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-71509-0_6

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