Abstract
Patient was a 62 years old female with non-small cell carcinoma/adenocarcinoma of the lung, treated with left lower lobectomy and started on adjuvant carboplatin and paclitaxel chemotherapy. Two days later, she felt very unwell with nausea, vomiting, fatigue, shortness of breath with exertion, and left-sided chest pain.
Troponin I was 0.329 (normal: less than 0.012 ng/ml).
ECG showed normal sinus rhythm with ST depression and T-wave inversion in inferolateral leads.
The ECG changes and elevated troponin confirm diagnosis of non-ST elevation myocardial infarction.
She underwent PCI to the LAD and RCA with a bare metal stent.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Valgimigli M, Patialiakas A, Thury A, McFadden E, Colangelo S, Campo G, et al. Zotarolimus-eluting versus bare-metal stents in uncertain drug-eluting stent candidates. J Am Coll Cardiol. 2015;65(8):805–15.
Long M, Ye Z, Zheng J, et al. Dual anti-platelet therapy following percutaneous coronary intervention in a population of patients with thrombocytopenia at baseline: a meta-analysis. BMC Pharmacol Toxicol. 2020;21:31.
McCarthy CP, Steg G, Bhatt DL. The management of antiplatelet therapy in acute coronary syndrome patients with thrombocytopenia: a clinical conundrum. Eur Heart J. 2017;38(47):3488.
Lluch A, Ojeda B, Colomer R, et al. Doxorubicin and paclitaxel in advanced breast carcinoma: importance of prior adjuvant anthracycline therapy. Cancer. 2000;89(11):2169–75. https://doi.org/10.1002/1097-0142(20001201)89:11<2169::aid-cncr4>3.0.co;2-9.
Giordano SH, Booser DJ, Murray JL, et al. A detailed evaluation of cardiac toxicity: a phase II study of doxorubicin and one- or three-hour-infusion paclitaxel in patients with metastatic breast cancer. Clin Cancer Res. 2002;8(11):3360–8.
Creager MA. Results of the CAPRIE trial: efficacy and safety of clopidogrel. Clopidogrel versus aspirin in patients at risk of ischaemic events. Vasc Med. 1998;3(3):257–60. https://doi.org/10.1177/1358836X9800300314.
Urban P, Meredith IT, Abizaid A, et al. Polymer-free drug-coated coronary stents in patients at high bleeding risk. N Engl J Med. 2015;373:2038–47.
Arbuck SG, Strauss H, Rowinsky E, et al. A reassessment of cardiac toxicity associated with Taxol. J Natl Cancer Inst Monogr. 1993;15:117–30.
Herrmann J, Yang EH, Iliescu CA, Cilingiroglu M, Charitakis K, Hakeem A, et al. Vascular toxicities of cancer therapies: the old and the new – an evolving avenue. Circulation. 2016;133:1272–89.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2021 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Rohani, A. (2021). Acute Coronary Syndrome in a Patient with Lung Cancer 2 Days After Second Cycle of Carboplatin and Paclitaxel. In: Clinical Cases in Cardio-Oncology. Clinical Cases in Cardiology. Springer, Cham. https://doi.org/10.1007/978-3-030-71155-9_15
Download citation
DOI: https://doi.org/10.1007/978-3-030-71155-9_15
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-71154-2
Online ISBN: 978-3-030-71155-9
eBook Packages: MedicineMedicine (R0)