Abstract
Patient was a 76-year-old female presented with worsening shortness of breath, both at rest and with exertion. Her Past Medical History was significant for bilateral breast cancer with involvement of the right supraclavicular lymph node, treated with bilateral mastectomies followed by chest wall and regional lymph node radiation ×50 fractions, completed 12 years ago.
Echocardiogram showed moderate Aortic valve Stenosis, severe Mitral valve Stenosis, normal LV size and systolic function and mitral valve area of 0.8 cm2. With this background, she was referred to Cardiac Surgery/Heart Valve Team. She was turned down because of prohibitive risk of cardiac surgery.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Moslehi J. The cardiovascular perils of cancer survivorship. N Engl J Med. 2013;368(11):1055–6. PMID: 23484833. https://doi.org/10.1056/NEJMe1215300.
Travis LB, Ng AK, Allan JM, Pui CH, Kennedy AR, Xu XG, Purdy JA, Applegate K, Yahalom J, Constine LS, Gilbert ES, Boice JD Jr. Second malignant neoplasms and cardiovascular disease following radiotherapy. J Natl Cancer Inst. 2012;104(5):357–70. Epub 2012 Feb 6. PMID: 22312134; PMCID: PMC3295744. https://doi.org/10.1093/jnci/djr533.
Giordano SH, Kuo YF, Freeman JL, Buchholz TA, Hortobagyi GN, Goodwin JS. Risk of cardiac death after adjuvant radiotherapy for breast cancer. J Natl Cancer Inst. 2005;97(6):419–24. PMID: 15770005; PMCID: PMC1853253. https://doi.org/10.1093/jnci/dji067.
Plana JC, Galderisi M, Barac A, Ewer MS, Ky B, Scherrer-Crosbie M, et al. Expert consensus for multimodality imaging evaluation of adult patients during and after cancer therapy: a report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging. 2014;15(10):1063–93. PMID: 25239940; PMCID: PMC4402366. https://doi.org/10.1093/ehjci/jeu192.
Lancellotti P, Nkomo VT, Badano LP, Bergler-Klein J, Bogaert J, Davin L, et al. European Society of Cardiology Working Groups on Nuclear Cardiology and Cardiac Computed Tomography and Cardiovascular Magnetic Resonance; American Society of Nuclear Cardiology; Society for Cardiovascular Magnetic Resonance; Society of Cardiovascular Computed Tomography. Expert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults: a report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. Eur Heart J Cardiovasc Imaging. 2013;14(8):721–40. Erratum in: Eur Heart J Cardiovasc Imaging. 2013 Dec;14(12):1217. PMID: 23847385. https://doi.org/10.1093/ehjci/jet123.
Desai MY, Wu M, Masri A, et al. Increased aorto-mitral curtain thickness independently predicts mortality in patients with radiation-associated cardiac disease undergoing cardiac surgery. Ann Thorac Surg. 2014;97:1348–55.
Reed GW, Masri A, Griffin BP, Kapadia SR, Ellis SG, Desai MY. Long-term mortality in patients with radiation-associated coronary artery disease treated with percutaneous coronary intervention. Circ Cardiovasc Interv. 2016;9
Donnellan E, Masri A, Johnston DR, et al. Long-term outcomes of patients with mediastinal radiation-associated severe aortic stenosis and subsequent surgical aortic valve replacement: a matched cohort study. J Am Heart Assoc. 2017;6
Darby SC, Ewertz M, McGale P, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med. 2013;368:987–98.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2021 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Rohani, A. (2021). Radiotherapy and Valvular Heart Disease. In: Clinical Cases in Cardio-Oncology. Clinical Cases in Cardiology. Springer, Cham. https://doi.org/10.1007/978-3-030-71155-9_14
Download citation
DOI: https://doi.org/10.1007/978-3-030-71155-9_14
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-71154-2
Online ISBN: 978-3-030-71155-9
eBook Packages: MedicineMedicine (R0)