Abstract
O-Linked glycosylation such as O-fucose, O-glucose, and O-N-acetylglucosamine are considered to be unusual. As suggested by the high levels of evolutional conservation, these O-glycans are fundamentally important for life. In the last two decades, our understanding of the importance of these glycans has greatly advanced. In particular, identification of the glycosyltransferases responsible for the biosynthesis of these glycans has accelerated basic research on the functional significance and molecular mechanisms by which these O-glycans regulate protein functions as well as clinical research on human diseases due to changes in these types of O-glycosylation. Notably, Notch receptor signaling is modified with and regulated by these types of O-glycans. Here, we summarize the current view of the structures and the significance of these O-glycans mainly in the context of Notch signaling regulation and human diseases.
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The authors would like to thank Prof. Tetsuya Okajima, Dr. Hiroki Hashiguchi, and the members of the Takeuchi group for their critical comments on this manuscript.
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The original work introduced in this chapter was partly supported by JSPS KAKENHI grant numbers JP19H03176, JP19K22490, and JP19KK0195 (to H.T.).
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Tsukamoto, Y., Takeuchi, H. (2021). Other Types of Glycosylation. In: Lauc, G., Trbojević-Akmačić, I. (eds) The Role of Glycosylation in Health and Disease. Advances in Experimental Medicine and Biology, vol 1325. Springer, Cham. https://doi.org/10.1007/978-3-030-70115-4_5
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