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The Biology of Dialysis

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Pediatric Dialysis

Abstract

The purpose of this chapter is to provide an overview of several basic principles underlying renal replacement therapies. After a review of uremic solutes, the dialytic solute removal mechanisms (diffusion, convection, and adsorption) broadly applicable to all renal replacement therapies are reviewed. New perspectives on the importance of specific membrane characteristics, including pore size and fiber inner diameter, are discussed. Fluid and mass transfer in peritoneal dialysis are assessed by examining the elements of the system: peritoneal microcirculation, peritoneal membrane, and the dialysate compartment. Finally, the fundamentals of solute removal kinetics are discussed.

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Author information

Authors and Affiliations

  1. Department of Chemical Engineering, Purdue University, West Lafayette, IN, USA

    William R. Clark

  2. Department of Medicine, University of Padova, Padova, Italy

    Claudio Ronco

  3. Department of Nephrology Dialysis and Transplantation, International Renal Research Institute (IRRIV), San Bortolo Hospital, Vicenza, Italy

    Claudio Ronco

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  1. William R. Clark
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  2. Claudio Ronco
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Correspondence to William R. Clark .

Editor information

Editors and Affiliations

  1. Department of Pediatrics, University of Missouri-Kansas City, School of Medicine, Division of Pediatric Nephrology, Children’s Mercy Kansas City, Kansas City, MO, USA

    Bradley A. Warady

  2. Stanford University School of Medicine, Division of Pediatric Nephrology, Department of Pediatrics, Palo Alto, CA, USA

    Steven R. Alexander

  3. Division of Pediatric Nephrology, Center for Pediatrics and Adolescent Medicine, University of Heidelberg, Heidelberg, Germany

    Franz Schaefer

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Clark, W.R., Ronco, C. (2021). The Biology of Dialysis. In: Warady, B.A., Alexander, S.R., Schaefer, F. (eds) Pediatric Dialysis. Springer, Cham. https://doi.org/10.1007/978-3-030-66861-7_2

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  • DOI: https://doi.org/10.1007/978-3-030-66861-7_2

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