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Healing Sulfurous Thermal Waters in Health Resort Medicine: Therapies, Indications, and Contraindications

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Minerals latu sensu and Human Health

Abstract

This chapter will mainly focus on the general assets and applications of sulfur- or H2S-bearing thermal mineral waters on a world scale. It deals with basic information on hydrogen sulfide properties, on biological effects, and on the therapies traditionally used in medical hydrology as treatment for skin, respiratory, and musculoskeletal disorders. The authors provide information on additional therapeutic benefits of sulfurous waters in diseases such as myalgia (muscle pain), rheumatic diseases (osteoarthritis, rheumatoid arthritis, fibromyalgia), respiratory diseases (upper and lower respiratory tracts), dermatological/skin diseases, cardiovascular diseases, and other diseases (cancer, wound healing in diabetic patients). Possible side effects or situations of diseases for which sulfurous thermal waters are contraindicated are reported too.

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References

  • Acciaiouoli LMC (1952) Le Portugal Hydromineral. Lisbonne, IV, 248 pp

    Google Scholar 

  • Albertini MC, Teodori L, Accorsi A, Soukri A, Campanella L, Baldoni F, Dachà M (2008) Sulphurous mineral water oral therapy: effects on erythrocyte metabolism. Food Chem Toxicol 46(10):3343–3350. https://doi.org/10.1016/j.fct.2008.08.008. Epub 2008 Aug 22

    Article  Google Scholar 

  • Balogh Z, Ordögh J, Gász A, Német L, Bender T (2005) Effectiveness of balneotherapy in chronic low back pain – a randomized single-blind controlled follow-up study. Forsch Komplementarmed Klass Naturheilkd 12(4):196–201. Epub 2005 Aug 29

    Google Scholar 

  • Bartels EM, Juhl CB, Christensen R, Hagen KB, Danneskiold-Samsøe B, Dagfinrud H, Lund H (2016) Aquatic exercise for the treatment of knee and hip osteoarthritis. Cochrane Database Syst Rev 3, CD005523. https://doi.org/10.1002/14651858.CD005523.pub3. Review

  • Bełtowski J (2015) Hydrogen sulphide in pharmacology and medicine – an update. Pharmacol Rep 67(3):647–658. https://doi.org/10.1016/j.pharep.2015.01.005. Epub 2015 Jan 22

  • Benchoam D, Cuevasanta E, Möller MN, Alvarez B (2019) Hydrogen sulphide and persulphides oxidation by biologically relevant oxidizing species. Antioxidants (Basel) 8(2):pii: E48. https://doi.org/10.3390/antiox8020048

    Article  Google Scholar 

  • Benedetti S, Benvenuti F, Nappi G et al (2009) Antioxidative effects of sulphurous mineral water: protection against lipid and protein oxidation. Eur J Clin Nutr 63:106–112

    Article  Google Scholar 

  • Benedetti S, Canino C, Tonti G, Medda V, Calcaterra P, Nappi G, Salaffi F, Canestrari F (2010) Biomarkers of oxidation, inflammation and cartilage degradation in osteoarthritis patients undergoing sulphur-based spa therapies. Clin Biochem 43(12):973–978. https://doi.org/10.1016/j.clinbiochem.2010.05.004. Epub 2010 May 20

    Article  Google Scholar 

  • Bhatia M (2015) H2S and inflammation: an overview. Handb Exp Pharmacol 230:165–180. https://doi.org/10.1007/978-3-319-18144-8_8. Review

    Article  Google Scholar 

  • Bir SC, Kolluru GK, McCarthy P, Shen X, Pardue S, Pattillo CB, Kevil CG (2012) Hydrogen sulphide stimulates ischemic vascular remodeling through nitric oxide synthase and nitrite reduction activity regulating hypoxia-inducible factor-1α and vascular endothelial growth factor-dependent angiogenesis. J Am Heart Assoc 1(5):e004093. https://doi.org/10.1161/JAHA.112.004093. Epub 2012 Oct 25

    Article  Google Scholar 

  • Brancaleone V, Roviezzo F, Vellecco V, De Gruttola L, Bucci M, Cirino G (2008) Biosynthesis of H2S is impaired in non-obese diabetic (NOD) mice. Br J Pharmacol 155(5):673–680. https://doi.org/10.1038/bjp.2008.296. Epub 2008 July 21

    Article  Google Scholar 

  • Branco M, Rêgo NN, Silva PH, Archanjo IE, Ribeiro MC, Trevisani VF (2016) Bath thermal waters in the treatment of knee osteoarthritis: a randomized controlled clinical trial. Eur J Phys Rehabil Med 52(4):422–430. Epub 2016 Feb 19

    Google Scholar 

  • Burguera EF, Vela-Anero A, Magalhães J, Meijide-Faílde R, Blanco FJ (2014) Effect of hydrogen sulphide sources on inflammation and catabolic markers on interleukin 1β-stimulated human articular chondrocytes. Osteoarthr Cartil 22(7):1026–1035. https://doi.org/10.1016/j.joca.2014.04.031. Epub 2014 May 14

    Article  Google Scholar 

  • Buskila D, Abu-Shakra M, Neumann L, Odes L, Shneider E, Flusser D, Sukenik S (2001) Balneotherapy for fibromyalgia at the Dead Sea. Rheumatol Int 20(3):105–108

    Article  Google Scholar 

  • Carbajo JM, Maraver F (2017) Sulphurous mineral waters: new applications for health. Evid Based Complement Alternat Med 2017:8034084. https://doi.org/10.1155/2017/8034084. Epub 2017 Apr 6

    Article  Google Scholar 

  • Carvalho MR, Cruz JV, Almeida C, Silva MO (1990) Hidrogeoquímica das águas dos granitos hercínicos das Beiras. In Geolis, Rev. da Sec. de Geol. Ec. e Aplic. 1990, IV (1,2), 229–248

    Google Scholar 

  • Chan SJ, Wong PT (2017) Reprint of: hydrogen sulphide in stroke: protective or deleterious? Neurochem Int 107:78–87. https://doi.org/10.1016/j.neuint.2016.11.016

    Article  Google Scholar 

  • Cheng Y, Ndisang JF, Tang G, Cao K, Wang (2004) Hydrogen sulphide-induced relaxation of resistance mesenteric artery beds of rats. Am J Physiol Heart Circ Physiol 287(5):H2316–H2323. Epub 2004 Jun 10

    Article  Google Scholar 

  • Contoli M, Gnesini G, Forini G, Marku B, Pauletti A, Padovani A, Casolari P, Taurino L, Ferraro A, Chicca M, Ciaccia A, Papi A, Pinamonti S (2013) Reducing agents decrease the oxidative burst and improve clinical outcomes in COPD patients: a randomised controlled trial on the effects of sulphurous thermal water inhalation. Sci World J 2013:927835. https://doi.org/10.1155/2013/927835. eCollection 2013

    Article  Google Scholar 

  • Cortez JA (2012) Águas Minerais Naturais e de Nascente da Região Centro. Mare Liberum – Editora 2012, FEDRAVE

    Google Scholar 

  • Costantino M, Lampa E, Nappi G (2006) Effectiveness of sulphur spa therapy with politzer in the treatment of rhinogenic deafness. Acta Otorhinolaryngol Ital 26(1):7–13

    Google Scholar 

  • Costantino M, Rossi F, Lampa E (2003) Inhalation therapy with sulphur water in ORL: clinical-experimental study. Clin Ter 154(6):395–400

    Google Scholar 

  • Cuevasanta E, Möller MN, Alvarez B (2017) Biological chemistry of hydrogen sulphide and persulphides. Arch Biochem Biophys 617:9–25. https://doi.org/10.1016/j.abb.2016.09.018. Epub 2016 Sep 30

    Article  Google Scholar 

  • Custodio E, Llamas MR (1983) Hidrogeología Subterránea. Vol I e II, 2ª Edição. 1983. Ed. Omega, Barcelona, 2350 pp

    Google Scholar 

  • Dongó E, Beliczai-Marosi G, Dybvig AS, Kiss L (2018) The mechanism of action and role of hydrogen sulphide in the control of vascular tone. Nitric Oxide 81:75–87. https://doi.org/10.1016/j.niox.2017.10.010. Epub 2017 Oct 31. Review

    Article  Google Scholar 

  • Dunn JD, Dion GR, KC MM (2013) Efficacy of nasal irrigations and nebulizations for nasal symptom relief. Curr Opin Otolaryngol Head Neck Surg 21(3):248–251. https://doi.org/10.1097/MOO.0b013e32835f80bb

    Article  Google Scholar 

  • El-Seweidy MM, Sadik NA, Shaker OG (2011) Role of sulphurous mineral water and sodium hydrosulphide as potent inhibitors of fibrosis in the heart of diabetic rats. Arch Biochem Biophys 506(1):48–57. https://doi.org/10.1016/j.abb.2010.10.014. Epub 2010 Oct 20

    Article  Google Scholar 

  • Erceg-Rukavina T, Stefanovski M (2015) Balneotherapy in treatment of spastic upper limb after stroke. Med Arch 69(1):31–33. https://doi.org/10.5455/medarh.2015.69.31-33. Epub 2015 Feb 21

    Article  Google Scholar 

  • Eto K, Asada T, Arima K, Makifuchi T, Kimura H (2002) Brain hydrogen sulphide is severely decreased in Alzheimer’s disease. Biochem Biophys Res Commun 293(5):1485–1488

    Article  Google Scholar 

  • Fang L, Li H, Tang C, Geng B, Qi Y, Liu X (2009) Hydrogen sulphide attenuates the pathogenesis of pulmonary fibrosis induced by bleomycin in rats. Can J Physiol Pharmacol 87(7):531–538. https://doi.org/10.1139/y09-039

    Article  Google Scholar 

  • Ferreira MO, Costa PC, Bahia MF (2010) Effect of São Pedro do Sul thermal water on skin irritation. Int J Cosmet Sci 32(3):205–210. https://doi.org/10.1111/j.1468-2494.2010.00527.x

    Article  Google Scholar 

  • Filipovic MR, Zivanovic J, Alvarez B, Banerjee R (2018) Chemical biology of H2S signaling through persulfidation. Chem Rev 118(3):1253–1337. https://doi.org/10.1021/acs.chemrev.7b00205. Epub 2017 Nov 7

    Article  Google Scholar 

  • Fioravanti A, Cantarini L, Guidelli GM, Galeazzi M (2011) Mechanisms of action of spa therapies in rheumatic diseases: what scientific evidence is there? Rheumatol Int 31(1):1–8. https://doi.org/10.1007/s00296-010-1628-6. Epub 2010 Dec 1

    Article  Google Scholar 

  • Forero BA (2009) Avaliação da Resistência à Corrosão sob Tensão e Suscetibilidade à Fragilização por Hidrogênio de Juntas Soldadas Circunferenciais de Aço API X-80. Rio de Janeiro: Pontifícia Universidade Católica

    Google Scholar 

  • Forestier R (2000) Magnitude and duration of the effects of two spa therapy courses on knee and hip osteoarthritis: an open prospective study in 51 consecutive patients. Joint Bone Spine 67(4):296–304

    Google Scholar 

  • Forestier R, Desfour H, Tessier J-M, Françon A, Foote A, Genty C, Rolland C, Roques C-F, Bosson J-L (2010) Spa therapy in the treatment of knee osteoarthritis: a large randomized multicentre trial. Ann Rheum Dis 69:660–665

    Article  Google Scholar 

  • Forestier R, Erol FB (2014) Is (creno) balneotherapy a drug, a surgical procedure or a non-pharmacological treatment? E-Letter on EULAR recommendations for the non-pharmacological core management of hip and knee osteoarthritis. Ann Rheum Dis 73(2):e6. http://dx.doi.org/10.1136/annrheumdis-2013-204787

  • Forestier R, Erol Forestier FB, Francon A (2016) Spa therapy and knee osteoarthritis: a systematic review. Ann Phys Rehabil Med 59(3):216–226. https://doi.org/10.1016/j.rehab.2016.01.010. Epub 2016 Mar 17

    Article  Google Scholar 

  • Gadalla MM, Snyder SH (2010) Hydrogen sulphide as a gasotransmitter. J Neurochem 113(1):14–26. https://doi.org/10.1111/j.1471-4159.2010.06580.x. Epub 2010 Jan 12. Review

    Article  Google Scholar 

  • Gálvez I, Torres-Piles S, Ortega-Rincón E (2018) Balneotherapy, immune system, and stress response: a hormetic strategy? Int J Mol Sci 19(6):pii: E1687. https://doi.org/10.3390/ijms19061687

    Article  Google Scholar 

  • Gobbi G, Ricci F, Malinverno C, Carubbi C, Pambianco M, Gd P, Vitale M, Mirandola P (2009) Hydrogen sulphide impairs keratinocyte cell growth and adhesion inhibiting mitogen-activated protein kinase signaling. Lab Investig 89(9):994–1006. https://doi.org/10.1038/labinvest.2009.61. Epub 2009 Jun 22

    Article  Google Scholar 

  • Guarnieri G, Ferrazzoni S, Scarpa MC, Lalli A, Maestrelli P (2010) Effects of inhalation of thermal water on exhaled breath condensate in chronic obstructive pulmonary disease. Respiration 79(3):216–221. https://doi.org/10.1159/000227801. Epub 2009 July 3

    Article  Google Scholar 

  • Guo W, Kan JT, Cheng ZY, Chen JF, Shen YQ, Xu J, Wu D, Zhu YZ (2012) Hydrogen sulphide as an endogenous modulator in mitochondria and mitochondria dysfunction. Oxidative Med Cell Longev 2012:878052. https://doi.org/10.1155/2012/878052. Epub 2012 Dec 5

    Article  Google Scholar 

  • Halevy S, Sukenik S (1998) Different modalities of spa therapy for skin diseases at the Dead Sea area. Arch Dermatol 134(11):1416–1420

    Article  Google Scholar 

  • Haouzi P (2016) Is exogenous hydrogen sulphide a relevant tool to address physiological questions on hydrogen sulphide? Respir PhysiolNeurobiol 229:5–10. https://doi.org/10.1016/j.resp.2016.03.015. Epub 2016 Mar 30

    Article  Google Scholar 

  • Hellmich MR, Szabo C (2015) Hydrogen Sulphide and Cancer. Handb Exp Pharmacol 230:233–241. https://doi.org/10.1007/978-3-319-18144-8_12. Review

    Article  Google Scholar 

  • Hosoki R, Matsuki N, Kimura H (1997) The possible role of hydrogen sulphide as an endogenous smooth muscle relaxant in synergy with nitric oxide. Biochem Biophys Res Commun 237(3):527–531

    Article  Google Scholar 

  • Hourihan JM, Kenna JG, Hayes JD (2013) The gasotransmitter hydrogen sulphide induces nrf2-target genes by inactivating the keap1 ubiquitin ligase substrate adaptor through formation of a disulphide bond between cys-226 and cys-613. Antioxid Redox Signal 19(5):465–481. https://doi.org/10.1089/ars.2012.4944. Epub 2013 Jan 16

    Article  Google Scholar 

  • HSDB (2006) Hydrogen sulfide: environmental standards & regulations. Hazardous Substances Databank National Library of Medicine, Bethesda. http://toxnetnlmnihgov/cgibin/sis/htmlgen?HSDB June 12, 2006

  • Hu Y, Chen X, Pan TT, Neo KL, Lee SW, Khin ES, Moore PK, Bian JS (2008) Cardioprotection induced by hydrogen sulphide preconditioning involves activation of ERK and PI3K/Akt pathways. Pflugers Arch 455(4):607–616. Epub 2007 Aug 1

    Article  Google Scholar 

  • Hu LF, Li Y, Neo KL, Yong QC, Lee SW, Tan BK, Bian JS (2011) Hydrogen sulphide regulates Na+/H+ exchanger activity via stimulation of phosphoinositide 3-kinase/Akt and protein kinase G pathways. J Pharmacol Exp Ther 39(2):726–735. https://doi.org/10.1124/jpet.111.184754. Epub 2011 Aug 24

    Article  Google Scholar 

  • Huang J, Luo YL, Hao Y, Zhang YL, Chen PX, Xu JW, Chen MH, Luo YF, Zhong NS, Xu J, Zhou WL (2014) Cellular mechanism underlying hydrogen sulphide induced mouse tracheal smooth muscle relaxation: role of BKCa. Eur J Pharmacol 741:55–63. https://doi.org/10.1016/j.ejphar.2014.07.004. Epub 2014 July 14

    Article  Google Scholar 

  • Jain SK, Bull R, Rains JL, Bass PF, Levine SN, Reddy S, McVie R, Bocchini JA (2010) Low levels of hydrogen sulphide in the blood of diabetes patients and streptozotocin-treated rats causes vascular inflammation? Antioxid Redox Signal 12(11):1333–1337. https://doi.org/10.1089/ars.2009.2956

    Article  Google Scholar 

  • Jin Z, Chan H, Ning J, Lu K, Ma D (2015) The role of hydrogen sulphide in pathologies of the vital organs and its clinical application. J Physiol Pharmacol 66(2):169–179

    Google Scholar 

  • Kashfi K (2014) Anti-cancer activity of new designer hydrogen sulphide-donating hybrids. Antioxid Redox Signal 20(5):831–846. https://doi.org/10.1089/ars.2013.5308. Epub 2013 Jun 7

    Article  Google Scholar 

  • Keller S, König V, Mösges R (2014) Thermal water applications in the treatment of upper respiratory tract diseases: a systematic review and meta-analysis. J Allergy (Cairo) 2014:943824. https://doi.org/10.1155/2014/943824. Epub 2014 Jun 1

    Article  Google Scholar 

  • Kida K, Yamada M, Tokuda K, Marutani E, Kakinohana M, Kaneki M et al (2010) Inhaled hydrogen sulphide prevents neurodegeneration and movement disorder in a mouse model of Parkinson’s disease. Antioxid Redox Signal 15:343–352

    Article  Google Scholar 

  • Kloesch B, Liszt M, Krehan D, Broell J, Kiener H, Steiner G (2012) High concentrations of hydrogen sulphide elevate the expression of a series of pro-inflammatory genes in fibroblast-like synoviocytes derived from rheumatoid and osteoarthritis patients. Immunol Lett 141(2):197–203. https://doi.org/10.1016/j.imlet.2011.10.004. Epub 2011 Oct 12

    Article  Google Scholar 

  • Kolluru GK, Shen X, Bir SC, Kevil CG (2013) Hydrogen sulphide chemical biology: pathophysiological roles and detection. Nitric Oxide 35:5–20. https://doi.org/10.1016/j.niox.2013.07.002. Epub 2013 July 9

    Article  Google Scholar 

  • Kovács C, Pecze M, Tihanyi Á, Kovács L, Balogh S, Bender T (2012) The effect of sulphurous water in patients with osteoarthritis of hand. Double-blind, randomized, controlled follow-up study. Clin Rheumatol 31(10):1437–1442. https://doi.org/10.1007/s10067-012-2026-0. Epub 2012 July 29

    Article  Google Scholar 

  • Kovács C, Bozsik Á, Pecze M, Borbély I, Fogarasi A, Kovács L, Tefner IK, Bender T (2016) Effects of Sulphur bath on hip osteoarthritis: a randomized, controlled, single-blind, follow-up trial: a pilot study. Int J Biometeorol 60(11):1675–1680. Epub 2016 Jun 21

    Article  Google Scholar 

  • Lee CC, Wu YH (2014) Sulphur spring dermatitis. Cutis 94(5):223–225

    Google Scholar 

  • Lewis RJ, Copley GB (2015) Chronic low-level hydrogen sulphide exposure and potential effects on human health: a review of the epidemiological evidence. Crit Rev Toxicol 45(2):93–123. https://doi.org/10.3109/10408444.2014.971943. Epub 2014 Nov 28

    Article  Google Scholar 

  • Li H, Feng SJ, Zhang GZ, Wang SX (2014) Correlation of lower concentrations of hydrogen sulphide with atherosclerosis in chronic hemodialysis patients with diabetic nephropathy. Blood Purif 38(3–4):188–194. https://doi.org/10.1159/000368883. Epub 2014 Dec 16

    Article  Google Scholar 

  • Li H, Wang Y, Wei C, Bai S, Zhao Y, Li H, Wu B, Wang R, Wu L, Xu C (2015) Mediation of exogenous hydrogen sulphide in recovery of ischemic post-conditioning-induced cardioprotection via down-regulating oxidative stress and up-regulating PI3K/Akt/GSK-3β pathway in isolated aging rat hearts. Cell Biosci 5:11. https://doi.org/10.1186/s13578-015-0003-4. eCollection 2015

    Article  Google Scholar 

  • Liang W, Chen J, Mo L, Ke X, Zhang W, Zheng D, Pan W, Wu S, Feng J, Song M, Liao X (2016) ATP-sensitive K+ channels contribute to the protective effects of exogenous hydrogen sulphide against high glucose-induced injury in H9c2 cardiac cells. Int J Mol Med 37(3):763–772. https://doi.org/10.3892/ijmm.2016.2467. Epub 2016 Jan 25

    Article  Google Scholar 

  • Lima A (2011) Origens do Fluido e da Mineralização das Águas Sulfúreas. Universidade do Minho 2011:29–48

    Google Scholar 

  • Liu J, Wu J, Sun A, Sun Y, Yu X, Liu N, Dong S, Yang F, Zhang L, Zhong X, Xu C, Lu F, Zhang W (2016) Hydrogen sulphide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway. Cell Biosci 6:33. https://doi.org/10.1186/s13578-016-0099-1. eCollection 2016

    Article  Google Scholar 

  • Lu M, Liu YH, Ho CY, Tiong CX, Bian JS (2012) Hydrogen sulphide regulates cAMP homeostasis and renin degranulation in As4.1 and rat renin-rich kidney cells. Am J Physiol Cell Physiol 302(1):C59–C66. https://doi.org/10.1152/ajpcell.00341.2010. Epub 2011 Sep 21

    Article  Google Scholar 

  • Mainier FB, Rocha ADA (2003) H2S: Novas Rotas de Remoção Química e Recuperação de Enxofre. 2° Congresso Brasileiro de P&D em Petróleo e Gás. 2003. Rio de Janeiro

    Google Scholar 

  • Mainier FB, Viola EDM (2005) O Sulfeto De Hidrogénio (H2S) e o Meio Ambiente, Universidade Federal Fluminense, INMETRO/LATEC (UFF). II Simpósio de Excelência em Gestão e Tecnologia – SEGeT. 2005

    Google Scholar 

  • Mancini S Jr, Piccinetti A, Nappi G, Mancini S, Caniato A, Coccheri S (2003) Clinical, functional and quality of life changes after balneokinesis with sulphurous water in patients with varicose veins. Vasa 32(1):26–30

    Article  Google Scholar 

  • Mani S, Li H, Untereiner A, Wu L, Yang G, Austin RC, Dickhout JG, Lhoták Š, Meng QH, Wang R (2013) Decreased endogenous production of hydrogen sulphide accelerates atherosclerosis. Circulation 127(25):2523–2534. https://doi.org/10.1161/CIRCULATIONAHA.113.002208. Epub 2013 May 23

    Article  Google Scholar 

  • Manna P, Jain SK (2013) L-cysteine and hydrogen sulphide increase PIP3 and AMPK/PPARγ expression and decrease ROS and vascular inflammation markers in high glucose treated human U937 monocytes. J Cell Biochem 114(10):2334–2345. https://doi.org/10.1002/jcb.24578

    Article  Google Scholar 

  • Manna P, Gungor N, McVie R, Jain SK (2014) Decreased cystathionine-γ-lyase (CSE) activity in livers of type 1 diabetic rats and peripheral blood mononuclear cells (PBMC) of type 1 diabetic patients. J Biol Chem 289(17):11767–11778. https://doi.org/10.1074/jbc.M113.524645. Epub 2014 Mar 7

    Article  Google Scholar 

  • Marutani E, Yamada M, Ida T, Tokuda K, Ikeda K, Kai S, Shirozu K, Hayashida K, Kosugi S, Hanaoka K, Kaneki M, Akaike T, Ichinose F (2015) Thiosulphate mediates cytoprotective effects of hydrogen sulphide against neuronal ischemia. J Am Heart Assoc 4(11):pii: e002125. https://doi.org/10.1161/JAHA.115.002125

    Article  Google Scholar 

  • Matz H, Orion E, Wolf R (2003) Balneotherapy in dermatology. Dermatol Ther 16(2):132–140

    Article  Google Scholar 

  • McAlindon TE, Bannuru RR, Sullivan MC, Arden NK, Berenbaum F, Bierma-Zeinstra SM, Hawker GA, Henrotin Y, Hunter DJ, Kawaguchi H, Kwoh K, Lohmander S, Rannou F, Roos EM, Underwood M (2014) OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthr Cartil 22(3):363–388. https://doi.org/10.1016/j.joca.2014.01.003. Epub 2014 Jan 24

    Article  Google Scholar 

  • Nagpure BV, Bian JS (2014) Hydrogen sulphide inhibits A2A adenosine receptor agonist induced β-amyloid production in SH-SY5Y neuroblastoma cells via a cAMP dependent pathway. PLoS One 9(2):e88508. https://doi.org/10.1371/journal.pone.0088508. eCollection 2014

    Article  Google Scholar 

  • Naumann J, Sadaghiani C (2014) Therapeutic benefit of balneotherapy and hydrotherapy in the management of fibromyalgia syndrome: a qualitative systematic review and meta-analysis of randomized controlled trials. Arthritis Res Ther 16(4):R141. https://doi.org/10.1186/ar4603

    Article  Google Scholar 

  • Nicholson CK, Calvert JW (2010) Hydrogen sulphide and ischemia-reperfusion injury. Pharmacol Res 62(4):289–297. https://doi.org/10.1016/j.phrs.2010.06.002. Epub 2010 Jun 11. Review

    Article  Google Scholar 

  • Nugraha B, Neues-Lahusen M, Candir F, Gutenbrunner C (2011) Effect of a series of H2S mineral water bathing on pain in patients with fibromyalgia syndrome – a pilot study. Physikalische Medizin Rehabilitationsmedizin Kurortmedizin 21(06):284–289

    Article  Google Scholar 

  • Nuvolone D, Petri D, Pepe P, Voller F (2019) Health effects associated with chronic exposure to low-level hydrogen sulphide from geothermoelectric power plants. A residential cohort study in the geothermal area of Mt. Amiata in Tuscany. Sci Total Environ 659:973–982. https://doi.org/10.1016/j.scitotenv.2018.12.363. Epub 2018 Dec 27

    Article  Google Scholar 

  • Ottaviano G, Marioni G, Staffieri C, Giacomelli L, Marchese-Ragona R, Bertolin A, Staffieri A (2011) Effects of sulphurous, salty, bromic, iodic thermal water nasal irrigations in nonallergic chronic rhinosinusitis: a prospective, randomized, double-blind, clinical, and cytological study. Am J Otolaryngol 32(3):235–239. https://doi.org/10.1016/j.amjoto.2010.02.004. Epub 2010 May 26

    Article  Google Scholar 

  • Pan LL, Liu XH, Gong QH, Wu D, Zhu YZ (2011) Hydrogen sulphide attenuated tumor necrosis factor-α-induced inflammatory signaling and dysfunction in vascular endothelial cells. PLoS One 6(5):e19766. https://doi.org/10.1371/journal.pone.0019766

    Article  Google Scholar 

  • Papapetropoulos A, Pyriochou A, Altaany Z, Yang G, Marazioti A, Zhou Z, Jeschke MG, Branski LK, Herndon DN, Wang R, Szabó C (2009) Hydrogen sulphide is an endogenous stimulator of angiogenesis. Proc Natl Acad Sci U S A 106(51):21972–21977. https://doi.org/10.1073/pnas.0908047106. Epub 2009 Dec 2

    Article  Google Scholar 

  • Paul BD, Snyder SH (2015) H2S: a novel Gasotransmitter that signals by Sulfhydration. Trends Biochem Sci 40(11):687–700. https://doi.org/10.1016/j.tibs.2015.08.007. Epub 2015 Oct 1

    Article  Google Scholar 

  • Paul BD, Sbodio JI, Xu R, Vandiver MS, Cha JY, Snowman AM, Snyder SH (2014) Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington’s disease. Nature 509(7498):96–100. https://doi.org/10.1038/nature13136. Epub 2014 Mar 26

    Article  Google Scholar 

  • Pellegrini M, Fanin D, Nowicki Y, Guarnieri G, Bordin A, Faggian D, Plebani M, Saetta M, Maestrelli P (2005) Effect of inhalation of thermal water on airway inflammation in chronic obstructive pulmonary disease. Respir Med 99(6):748–754. Epub 2004 Dec 13

    Article  Google Scholar 

  • Perry MM, Hui CK, Whiteman M, Wood ME, Adcock I, Kirkham P, Michaeloudes C, Chung KF (2011) Hydrogen sulphide inhibits proliferation and release of IL-8 from human airway smooth muscle cells. Am J Respir Cell Mol Biol 45(4):746–752. https://doi.org/10.1165/rcmb.2010-0304OC. Epub 2011 Feb 4

    Article  Google Scholar 

  • Prandelli C, Parola C, Buizza L, Delbarba A, Marziano M, Salvi V, Zacchi V, Memo M, Sozzani S, Calza S, Uberti D, Bosisio D (2013) Sulphurous thermal water increases the release of the anti-inflammatory cytokine IL-10 and modulates antioxidant enzyme activity. Int J Immunopathol Pharmacol 26(3):633–646

    Article  Google Scholar 

  • Qian LL, Liu XY, Chai Q, Wang RX (2018) Hydrogen Sulphide in diabetic complications: focus on molecular mechanisms. Endocr Metab Immune Disord Drug Targets 18(5):470–476. https://doi.org/10.2174/1871530318666180426100532

    Article  Google Scholar 

  • Qipshidze N, Metreveli N, Mishra PK, Lominadze D (2012) Hydrogen sulphide mitigates cardiac remodeling during myocardial infarction via improvement of angiogenesis. Int J Biol Sci 8(4):430–441. https://doi.org/10.7150/ijbs.3632. Epub 2012 Feb 28

    Article  Google Scholar 

  • Safar MM, Abdelsalam RM (2015) H2S donors attenuate diabetic nephropathy in rats: modulation of oxidant status and polyol pathway. Pharmacol Rep 67(1):17–23. https://doi.org/10.1016/j.pharep.2014.08.001. Epub 2014 Aug 20

    Article  Google Scholar 

  • Salami A, Dellepiane M, Crippa B, Mora F, Guastini L, Jankowska B, Mora R (2008) Sulphurous water inhalations in the prophylaxis of recurrent upper respiratory tract infections. Int J Pediatr Otorhinolaryngol 72(11):1717–1722. https://doi.org/10.1016/j.ijporl.2008.08.014. Epub 2008 Sep 24

    Article  Google Scholar 

  • Salami A, Dellepiane M, Strinati F, Guastini L, Mora R (2010) Sulphurous thermal water inhalations in the treatment of chronic rhinosinusitis. Rhinology 48(1):71–76. https://doi.org/10.4193/Rhin09.065

    Article  Google Scholar 

  • Santos I, Cantista P, Vasconcelos C, Amado J (2016) Balneotherapy and rheumatoid arthritis: a randomized control trial. Isr Med Assoc J 18(8):474–478

    Google Scholar 

  • Sellak H, Choi CS, Dey NB, Lincoln TM (2013) Transcriptional and post-transcriptional regulation of cGMP-dependent protein kinase (PKG-I): pathophysiological significance. Cardiovasc Res 97(2):200–207. https://doi.org/10.1093/cvr/cvs327. Epub 2012 Nov 8

    Article  Google Scholar 

  • Sen N (2017) Functional and molecular insights of hydrogen sulphide signaling and protein sulfhydration. J Mol Biol 429(4):543–561. https://doi.org/10.1016/j.jmb.2016.12.015. Epub 2016 Dec 21

    Article  Google Scholar 

  • Skrtic L (2006) Hydrogen sulfide, oil and gas, and people’s health. Master’s of Science. Energy and Resources Group, University of California, Berkeley, 2006: 1–77

    Google Scholar 

  • Štambuk-Giljanović N (2008) Characteristics and origin of the hydrogen sulphide spring water from the Split spa (Southern Croatia). Environ Monit Assess 140:109–117. https://doi.org/10.1007/s10661-007-9852-6

    Article  Google Scholar 

  • Steudler PA, Peterson BJ (1984) Contribution of gaseous sulphur from salt marshes to the global sulphur cycle. Nature 311:455–457

    Article  Google Scholar 

  • Sukenik S, Flusser D, Abu-Shakra M (1999) The role of spa therapy in various rheumatic diseases. Rheum Dis Clin N Am 25:883–897

    Article  Google Scholar 

  • Sukenik S, Buskila D, Neumann L, Kleiner-Baumgarten A, Zimlichman S, Horowitz J (1990) Sulphur bath and mud pack treatment for rheumatoid arthritis at the Dead Sea area. Ann Rheum Dis 49(2):99–102

    Article  Google Scholar 

  • Sun CC, Sue MS (1995) Sulphur spring dermatitis. Contact Dermatitis 32(1):31–34

    Article  Google Scholar 

  • Sun L, Zhang S, Yu C, Pan Z, Liu Y, Zhao J, Wang X, Yun F, Zhao H, Yan S, Yuan Y, Wang D, Ding X, Liu G, Li W, Zhao X, Liu Z, Li Y (2015) Hydrogen sulphide reduces serum triglyceride by activating liver autophagy via the AMPK-mTOR pathway. Am J Physiol Endocrinol Metab 309(11):E925–E935. https://doi.org/10.1152/ajpendo.00294.2015. Epub 2015 Oct 6

    Article  Google Scholar 

  • Suzuki K, Sagara M, Aoki C, Tanaka S, Aso Y (2017) Clinical implication of plasma hydrogen sulphide levels in Japanese patients with type 2 diabetes. Intern Med 56(1):17–21. https://doi.org/10.2169/internalmedicine.56.7403. Epub 2017 Jan 1

    Article  Google Scholar 

  • Tang G, Wu L, Liang W, Wang R (2005) Direct stimulation of K(ATP) channels by exogenous and endogenous hydrogen sulphide in vascular smooth muscle cells. Mol Pharmacol 68(6):1757–1764. Epub 2005 Sep 8

    Article  Google Scholar 

  • Toussaint C, Peuchant E, Nguyen BC, Jensen R, Canellas J (1986) Influence of calcic and magnesic sulphurous thermal water on the metabolism of lipoproteins in the rat. Arch Int Physiol Biochim 94(2):65–76

    Google Scholar 

  • US National Research Council (1979) Subcommittee on hydrogen sulfide. University Park Press, Baltimore

    Google Scholar 

  • Valenzuela MA (1968) Compêndio de Hidrologia Médica, Ed. Científico – Médico, Barcelona

    Google Scholar 

  • Vandiver MS, Paul BD, Xu R, Karuppagounder S, Rao F, Snowman AM, Ko HS, Lee YI, Dawson VL, Dawson TM, Sen N, Snyder SH (2013) Sulfhydration mediates neuroprotective actions of parkin. Nat Commun 4:1626. https://doi.org/10.1038/ncomms2623

    Article  Google Scholar 

  • Varricchio A, Giuliano M, Capasso M, Del Gaizo D, Ascione E, De Lucia A, Avvisati F, Capuano F, De Rosa G, Di Mauro F, Ciprandi G (2013) Salso-sulphide thermal water in the prevention of recurrent respiratory infections in children. Int J Immunopathol Pharmacol 26(4):941–952

    Article  Google Scholar 

  • Verhagen AP, Bierma-Zeinstra SM, Boers M, Cardoso JR, Lambeck J, de Bie R, de Vet HC (2015) Balneotherapy (or spa therapy) for rheumatoid arthritis. Cochrane Database Syst Rev (4):CD000518. https://doi.org/10.1002/14651858.CD000518.pub2

  • Wakabayashi N, Dinkova-Kostova AT, Holtzclaw WD, Kang MI, Kobayashi A, Yamamoto M, Kensler TW, Talalay P (2004) Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers. Proc Natl Acad Sci U S A 101(7):2040–2045. Epub 2004 Feb 5

    Article  Google Scholar 

  • Wallace JL, Ferraz JG, Muscara MN (2012) Hydrogen sulphide: an endogenous mediator of resolution of inflammation and injury. Antioxid Redox Signal 17(1):58–67. https://doi.org/10.1089/ars.2011.4351. Epub 2011 Dec 15

    Article  Google Scholar 

  • Wang X, Wang Q, Guo W, Zhu YZ (2011) Hydrogen sulphide attenuates cardiac dysfunction in a rat model of heart failure: a mechanism through cardiac mitochondrial protection. Biosci Rep 31(2):87–98. https://doi.org/10.1042/BSR20100003

    Article  Google Scholar 

  • Wetzel MD, Wenke JC (2019) Mechanisms by which hydrogen sulphide attenuates muscle function following ischemia-reperfusion injury: effects on Akt signaling, mitochondrial function, and apoptosis. J Transl Med 17(1):33. https://doi.org/10.1186/s12967-018-1753-7

    Article  Google Scholar 

  • WHO (World Health Organization) (1981) Hydrogen sulfide. Geneva, Environmental Health Criteria. 1981 No. 19

    Google Scholar 

  • WHO (World Health Organization) (2000) Chapter 6.6 Hydrogen sulfide. In: Air quality guidelines, 2nd edn. WHO Regional Office for Europe, Copenhagen

    Google Scholar 

  • World Health Organization (2003) Concise International Chemical Assessment Document 53, Hydrogen sulphide: human health Aspects

    Google Scholar 

  • Xiao T, Luo J, Wu Z, Li F, Zeng O, Yang J (2015) Effects of hydrogen sulphide on myocardial fibrosis and PI3K/AKT1-regulated autophagy in diabetic rats. Mol Med Rep 13(2):1765–1773. https://doi.org/10.3892/mmr.2015.4689. Epub 2015 Dec 17

    Article  Google Scholar 

  • Xu S, Liu Z, Liu P (2014) Targeting hydrogen sulphide as a promising therapeutic strategy for atherosclerosis. Int J Cardiol 172(2):313–317. https://doi.org/10.1016/j.ijcard.2014.01.068. Epub 2014 Jan 24

    Article  Google Scholar 

  • Xu W, Chen J, Lin J, Liu D, Mo L, Pan W, Feng J, Wu W, Zheng D (2015) Exogenous H2S protects H9c2 cardiac cells against high glucose-induced injury and inflammation by inhibiting the activation of the NF-κB and IL-1β pathways. Int J Mol Med 35(1):177–186. https://doi.org/10.3892/ijmm.2014.2007. Epub 2014 Nov 19

    Article  Google Scholar 

  • Yang G, Yang W, Wu L, Wang R (2007) H2S, endoplasmic reticulum stress, and apoptosis of insulin-secreting beta cells. J Biol Chem 282(22):16567–16576. Epub 2007 Apr 12

    Article  Google Scholar 

  • Yang G, Wu L, Jiang B, Yang W, Qi J, Cao K, Meng Q, Mustafa AK, Mu W, Zhang S, Snyder SH, Wang R (2008) H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science 322(5901):587–590. https://doi.org/10.1126/science.1162667

    Article  Google Scholar 

  • Yang CT, Zhao Y, Xian M, Li JH, Dong Q, Bai HB, Xu JD, Zhang MF (2014) A novel controllable hydrogen sulphide-releasing molecule protects human skin keratinocytes against methylglyoxal-induced injury and dysfunction. Cell Physiol Biochem 34(4):1304–1317. https://doi.org/10.1159/000366339. Epub 2014 Sep 29

    Article  Google Scholar 

  • Yu XH, Cui LB, Wu K, FS ZXLC, Chen ZW, Tang CK (2014) Hydrogen sulphide as a potent cardiovascular protective agent. Clin Chim Acta 437:78–87. https://doi.org/10.1016/j.cca.2014.07.012. Epub 2014 July 21

    Article  Google Scholar 

  • Yurtkuran M, Yurtkuran M, Alp A, Nasircilar A, Bingöl U, Altan L, Sarpdere G (2006) Balneotherapy and tap water therapy in the treatment of knee osteoarthritis. Rheumatol Int 27(1):19–27. Epub 2006 July 11

    Article  Google Scholar 

  • Zhen Y, Pan W, Hu F, Wu H, Feng J, Zhang Y, Chen J (2015) Exogenous hydrogen sulphide exerts proliferation/anti-apoptosis/angiogenesis/migration effects via amplifying the activation of NF-κB pathway in PLC/PRF/5 hepatoma cells. Int J Oncol 46(5):2194–2204. https://doi.org/10.3892/ijo.2015.2914. Epub 2015 Mar 3

    Article  Google Scholar 

  • Zwolińska JI, Weres AI, Wyszyńska JI (2018) One-year follow-up of spa treatment in older patients with osteoarthritis: a prospective, single group study. Biomed Res Int 2018:7492106. https://doi.org/10.1155/2018/7492106. E Collection 2018

    Article  Google Scholar 

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Amado, F.M.L., Silva, E.A.F. (2021). Healing Sulfurous Thermal Waters in Health Resort Medicine: Therapies, Indications, and Contraindications. In: Gomes, C., Rautureau, M. (eds) Minerals latu sensu and Human Health. Springer, Cham. https://doi.org/10.1007/978-3-030-65706-2_15

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