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Possible Mechanisms and Special Clinical Considerations of Curcumin Supplementation in Patients with COVID-19

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Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1308))

Abstract

The novel coronavirus outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was recognized in late 2019 in Wuhan, China. Subsequently, the World Health Organization declared coronavirus disease 2019 (COVID-19) as a pandemic on 11 March 2020. The proportion of potentially fatal coronavirus infections may vary by location, age, and underlying risk factors. However, acute respiratory distress syndrome (ARDS) is the most frequent complication and leading cause of death in critically ill patients. Immunomodulatory and anti-inflammatory agents have received great attention as therapeutic strategies against COVID-19. Here, we review potential mechanisms and special clinical considerations of supplementation with curcumin as an anti-inflammatory and antioxidant compound in the setting of COVID-19 clinical research.

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Authors and Affiliations

  1. Department of Clinical Pharmacy, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

    Zinat Heidari

  2. Department of Pharmaceutics, Faculty of pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

    Marzieh Mohammadi

  3. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  4. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  5. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  6. Polish Mother’s Memorial Hospital Research Institute (PMMHRI), Lodz, Poland

    Amirhossein Sahebkar

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  1. Zinat Heidari
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  2. Marzieh Mohammadi
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  3. Amirhossein Sahebkar
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Correspondence to Amirhossein Sahebkar .

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Editors and Affiliations

  1. Department of Biological Sciences, University of Limerick, Limerick, Ireland

    George E. Barreto

  2. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

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Heidari, Z., Mohammadi, M., Sahebkar, A. (2021). Possible Mechanisms and Special Clinical Considerations of Curcumin Supplementation in Patients with COVID-19. In: Barreto, G.E., Sahebkar, A. (eds) Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health. Advances in Experimental Medicine and Biology, vol 1308. Springer, Cham. https://doi.org/10.1007/978-3-030-64872-5_11

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