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Effect of Curcumin on Severity of Functional Dyspepsia: a Triple Blinded Clinical Trial

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Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1308))

Abstract

Background

Functional dyspepsia is the main cause of upper abdominal discomfort affecting 5–10% of the world population. Despite various therapeutic approaches, up to 50% of patients with functional dyspepsia seek alternative treatments. In the present study we evaluated the effect of curcumin supplementation along with famotidine therapy on severity of functional dyspepsia. A total of 75 patients with functional dyspepsia according to Rome III criteria were allocated into intervention (N = 39) or control (N = 36) groups. The intervention group was treated with a combination of 500 mg curcumin and 40 mg famotidine daily for 1 month. The control group received placebo and 40 mg famotidine. Severity of dyspepsia symptoms was determined using the Hong Kong questionnaire at baseline, after the 1 month treatment and after a 1 month follow-up. The presence of H. pylori antigens in the stool samples was also investigated in all subjects. No significant difference was observed between intervention and control groups in biochemical indices, severity of dyspepsia and rate of H. pylori infection. A significant decrease was observed in severity of dyspepsia (p < 0.001) and rate of H. pylori infection (p = 0.004) immediately after the treatment and follow-up in the curcumin intervention group. This study indicated that curcumin therapy could be a favorable supplementation in the symptom management of functional dyspepsia. Moreover, curcumin could help efficient eradication of H. pylori in these patients.

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Conflict of Interest

Muhammed Majeed is the founder of Sabinsa Corp. and Sami Labs Ltd. The other authors declare no competing interests.

Funding

This study was supported by the Research Council at the Baqiyatallah University of Medical Sciences.

Author information

Authors and Affiliations

  1. Pharmacotherapy Department, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran

    Yunes Panahi

  2. Gastroenterology and Hepatology Department, Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran

    Ashraf Karbasi

  3. Baqiyatallah Research Center for Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, Iran

    Ghasem Valizadegan

  4. Baqiyatallah Hospital, Tehran, Iran

    Nayyereh Ostadzadeh

  5. School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Sara Saffar Soflaei

  6. Department of Food Science and Technology, Quchan Branch, Islamic Azad University, Quchan, Iran

    Tannaz Jamialahmadi

  7. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Tannaz Jamialahmadi

  8. Sabinsa Corporation, East Windsor, NJ, USA

    Muhammed Majeed

  9. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  10. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  11. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  12. Polish Mother’s Memorial Hospital Research Institute (PMMHRI), Lodz, Poland

    Amirhossein Sahebkar

Authors
  1. Yunes Panahi
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  2. Ashraf Karbasi
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  3. Ghasem Valizadegan
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  5. Sara Saffar Soflaei
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  6. Tannaz Jamialahmadi
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  7. Muhammed Majeed
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  8. Amirhossein Sahebkar
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Corresponding authors

Correspondence to Ashraf Karbasi or Amirhossein Sahebkar .

Editor information

Editors and Affiliations

  1. Department of Biological Sciences, University of Limerick, Limerick, Ireland

    George E. Barreto

  2. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

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Panahi, Y. et al. (2021). Effect of Curcumin on Severity of Functional Dyspepsia: a Triple Blinded Clinical Trial. In: Barreto, G.E., Sahebkar, A. (eds) Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health. Advances in Experimental Medicine and Biology, vol 1308. Springer, Cham. https://doi.org/10.1007/978-3-030-64872-5_10

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