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The Effect of Curcumin Supplementation on Pulse Wave Velocity in Patients with Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial

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Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1308))

Abstract

Cardiovascular disease is a leading cause of death in many societies. Arterial stiffness is an initial sign of structural and functional changes in the arterial wall. Pulse wave velocity (PWV) is the gold standard for non-invasive evaluation of aortic stiffness and a modifiable cardiovascular risk factor. Curcumin is a major component of turmeric with known anti-inflammatory and anti-oxidative effects. Since arterial stiffness is affected by inflammation and oxidative stress, it may be improved by curcumin supplementation. The purpose of this clinical trial was to investigate the potential effects of curcumin on improving arterial stiffness in patients with metabolic syndrome. This placebo-controlled, double-blind, randomized clinical trial was conducted among metabolic syndrome patients. Sixty-six eligible individuals were randomly assigned to active intervention or control groups. The active intervention group received curcumin supplement at a dose of 500 mg daily for 12 weeks, whereas the control group received placebo capsule. Physical activity, daily dietary energy intake, anthropometric body composition, and biochemical hemodynamic and arterial stiffness parameters were evaluated at baseline and at the end of the study. Body weight decreased significantly in the curcumin group compared to placebo. Also, curcumin intervention improved PWV, which remained significant after adjustment for potential confounding factors (p = 0.011). The current clinical trial demonstrated that daily intake of 500 mg of curcumin for 12 weeks can lead to the improvement of arterial stiffness and weight management among subjects with metabolic syndrome.

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Conflict of Interest

None of the authors had declarations of interest to publish.

Funding

This research was financed by Research Council of the Mashhad University of Medical Sciences, Mashhad, Iran. The results reported in this paper have been derived from a postgraduate thesis (Thesis No: 1445) in Mashhad University of Medical Sciences, Mashhad, Iran.

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Authors and Affiliations

  1. Department of Nutrition, Faculty of medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Mona Alidadi, Maryam Alinezhad-Namaghi, Seyed Mostafa Arabi & Abdolreza Norouzy

  2. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  3. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  4. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  5. Polish Mother’s Memorial Hospital Research Institute (PMMHRI), Lodz, Poland

    Amirhossein Sahebkar & Saeid Eslami

  6. Department of Cardiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Farveh Vakilian

  7. Department of Community Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Lida Jarahi

  8. Medical Genetics Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran

    Saba Vakili

  9. Department of Medical Informatics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Fariba Tohidinezhad

  10. Medical Student, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Yasaman Nikooiyan

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  1. Mona Alidadi
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  2. Amirhossein Sahebkar
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  3. Saeid Eslami
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  4. Farveh Vakilian
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  5. Lida Jarahi
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  6. Maryam Alinezhad-Namaghi
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  7. Seyed Mostafa Arabi
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  8. Saba Vakili
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  9. Fariba Tohidinezhad
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  10. Yasaman Nikooiyan
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  11. Abdolreza Norouzy
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Correspondence to Abdolreza Norouzy .

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Editors and Affiliations

  1. Department of Biological Sciences, University of Limerick, Limerick, Ireland

    George E. Barreto

  2. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

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Alidadi, M. et al. (2021). The Effect of Curcumin Supplementation on Pulse Wave Velocity in Patients with Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. In: Barreto, G.E., Sahebkar, A. (eds) Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health. Advances in Experimental Medicine and Biology, vol 1308. Springer, Cham. https://doi.org/10.1007/978-3-030-64872-5_1

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