The Role of Vaccines in Combating Antimicrobial Resistance

Jansen, Kathrin U.; Gruber, William C.; Simon, Raphael; Wassil, James; Anderson, Annaliesa S.

doi:10.1007/978-3-030-58259-3_10

Kathrin U. Jansen⁷,
William C. Gruber⁷,
Raphael Simon⁷,
James Wassil⁸^nAff9 &
…
Annaliesa S. Anderson⁷

Part of the book series: Sustainable Agriculture Reviews ((SARV,volume 49))

638 Accesses
3 Citations

Abstract

The introduction of new classes of antibiotics, and the high use of antimicrobials in healthcare, agriculture, and the food industry, have all contributed to accelerate the development of antimicrobial resistance (AMR) in bacterial species and dissemination of antibiotic resistant bacterial strains worldwide. At present, the dramatic rise in AMR among important human bacterial pathogens is reaching a state of global crisis threatening a return to the pre-antibiotic era. AMR, already a significant burden on public health and economies, is anticipated to grow even more severe in the coming decades.

The utility of vaccines to fight AMR has been broadly recognized. Several licensed vaccines, targeting both bacterial (Haemophilus influenzae , Streptococcus pneumoniae , Salmonella enterica serotype Typhi) and viral (influenza virus, rotavirus) pathogens, have already proven their anti-AMR benefits by reducing unwarranted antibiotic consumption and antibiotic resistant bacterial strains and by promoting herd immunity, thereby protecting indirectly even segments in a population that have not been or cannot be vaccinated. It is further encouraging that a number of new investigational vaccines, with a potential to reduce the spread of multi drug resistant bacterial pathogens, are in various stages of clinical development. Nevertheless, vaccines as a tool to combat AMR remain underappreciated and unfortunately underutilized. Global mobilization of public health and industry resources is key to maximizing the use of licensed vaccines, and the development of new prophylactic vaccines could have a profound impact on reducing AMR.

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The impact of human vaccines on bacterial antimicrobial resistance. A review

Article 29 September 2021

The role of vaccines in combatting antimicrobial resistance

Article 04 February 2021

The role of vaccines in preventing bacterial antimicrobial resistance

Article 01 January 2018

Abbreviations

AMR:: Antimicrobial resistance
BCG:: Bacillus Calmette Guérin
CARB-X:: Combating Antibiotic Resistant Bacteria Biopharmaceutical Accelerator
CDC:: Centers for Disease Control and Prevention
CRM₁₉₇:: Cross-reactive material 197
EU:: European Union
GAVI:: Global Alliance for Vaccines and Immunization
GBS:: Group B streptococcus
Hib:: Haemophilus influenzae type b
HIV:: Human immunodeficiency virus
IgA:: Immunoglobulin A
IgG:: Immunoglobulin G
NDM-1:: New Delhi metallo-β-lactamase 1
PCV:: Polysaccharide conjugate vaccine
RSV:: Respiratory syncytial virus
UK:: United Kingdom
U.S.:: United States
WHO:: World Health Organization

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Acknowledgements

The authors thank the following Pfizer colleagues: Natasha Kushnir, PhD for scientific writing, Robert Donald, PhD and Kirstin Heinrich, MPH for critical review of the manuscript, and Dawn De Thomas for graphics preparation.

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All authors were employees of Pfizer at time of writing. The chapter preparation was funded by Pfizer.

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James Wassil
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Pfizer Vaccine Research and Development, Pearl River, NY, USA
Kathrin U. Jansen, William C. Gruber, Raphael Simon & Annaliesa S. Anderson
Pfizer Patient and Health Impact, Collegeville, PA, USA
James Wassil

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Kathrin U. Jansen
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William C. Gruber
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Raphael Simon
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Department of Dairy Microbiology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India
Harsh Panwar
Alpine Biomedicals Pvt. Ltd., Ambala, India
Chetan Sharma
Aix-Marseille University, CNRS, IRD, INRAE, Coll France, CEREGE, Aix-en-Provence, France
Eric Lichtfouse

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Jansen, K.U., Gruber, W.C., Simon, R., Wassil, J., Anderson, A.S. (2021). The Role of Vaccines in Combating Antimicrobial Resistance. In: Panwar, H., Sharma, C., Lichtfouse, E. (eds) Sustainable Agriculture Reviews 49. Sustainable Agriculture Reviews, vol 49. Springer, Cham. https://doi.org/10.1007/978-3-030-58259-3_10

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The Role of Vaccines in Combating Antimicrobial Resistance

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The impact of human vaccines on bacterial antimicrobial resistance. A review

The role of vaccines in combatting antimicrobial resistance

The role of vaccines in preventing bacterial antimicrobial resistance

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The Role of Vaccines in Combating Antimicrobial Resistance

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The impact of human vaccines on bacterial antimicrobial resistance. A review

The role of vaccines in combatting antimicrobial resistance

The role of vaccines in preventing bacterial antimicrobial resistance

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