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Neurobiology of Posttraumatic Stress Disorder

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PET and SPECT in Psychiatry

Abstract

This chapter illustrates the functional and anatomical alterations that occur in patients affected by posttraumatic stress disorder (PTSD). Most of these studies have been carried out over the last three decades with advanced neuroimaging techniques and have contributed significantly to describ the model of neurobiological changes underlying PTSD, implying an unbalance between hyperactivation of the amygdala following a traumatic event and the resulting inhibitory action of the prefrontal cortex. The findings of neuroimaging studies in most of the regions whose functional and anatomical changes account for PTSD symptoms will be described as well as the implication of these changes in the disorder of the three main brain connectivity networks.

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Authors and Affiliations

  1. Department of Clinical and Biological Sciences, University of Turin, Turin, Italy

    Sara Carletto

  2. Department of Psychology, University of Turin, Turin, Italy

    Melissa Panero

  3. e Campus University, Novedrate, Como, Italy

    Marco Cavallo

  4. Institute of Cognitive Sciences and Technologies, CNR, Rome, Italy

    Marco Pagani

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  1. Sara Carletto
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  2. Melissa Panero
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  3. Marco Cavallo
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  4. Marco Pagani
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Correspondence to Marco Pagani .

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Editors and Affiliations

  1. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Rudi A.J.O. Dierckx

  2. Faculty of Electrical Engineering, Medical Engineering and Computer Science, Offenburg University, Offenburg, Germany

    Andreas Otte

  3. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Erik F. J. de Vries

  4. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Aren van Waarde

  5. Biomedical Sciences of Cells and Systems, University Medical Center Groningen, Groningen, The Netherlands

    Iris E. Sommer

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Carletto, S., Panero, M., Cavallo, M., Pagani, M. (2021). Neurobiology of Posttraumatic Stress Disorder. In: Dierckx, R.A., Otte, A., de Vries, E.F.J., van Waarde, A., Sommer, I.E. (eds) PET and SPECT in Psychiatry. Springer, Cham. https://doi.org/10.1007/978-3-030-57231-0_11

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