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Types and Origin of Stem Cells

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Stem Cell Therapy for Vascular Diseases

Abstract

The main characteristics of stem cells are related to their undifferentiated state and their ability to self-renew and to differentiate. They may be referred to as embryonic or adult stem cells according to their appearance either in the inner cell mass of the embryo or in specific tissues throughout the fetal and postnatal life. They may also be characterized according to their developmental potency as totipotent, pluripotent, multipotent, or unipotent cells. Also, they may be obtained from their natural niche (the specific microenvironment where they reside) or may be engineered ex vivo by reprogramming somatic cells, then referred to as induced pluripotent stem cells. Based on the concept that stem cells are the organizing principle for tissue formation and homeostasis, their clinical application was a matter of time. This chapter describes the types and origin of stem cells and discusses their potential for cell therapy for vascular diseases.

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Authors and Affiliations

  1. Physiology and Biophysics, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil

    Lucíola da Silva Barcelos & Pollyana Ribeiro Castro

  2. Department of Cardiology, Campus Benjamin Franklin, Charité – Universitätsmedizin Berlin, Berlin, Germany

    Elisabeth Tamara Straessler & Nicolle Kränkel

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  1. Lucíola da Silva Barcelos
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Editors and Affiliations

  1. Department of Surgery, Vascular Surgery Section, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Tulio Pinho Navarro

  2. Postgraduate Program in Sciences Applied to Surgery, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Lara Lellis Navarro Minchillo Lopes

  3. Vascular Biology and Therapeutics Program and the Departments of Surgery and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA

    Alan Dardik

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da Silva Barcelos, L., Castro, P.R., Straessler, E.T., Kränkel, N. (2021). Types and Origin of Stem Cells. In: Navarro, T.P., Minchillo Lopes, L.L.N., Dardik, A. (eds) Stem Cell Therapy for Vascular Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-56954-9_2

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