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Mesenchymal Stem Cell and Endothelial Progenitor Cell Transplantation for Buerger’s Disease

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Stem Cell Therapy for Vascular Diseases

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Abstract

Buerger’s disease is a rare disease affecting the blood vessels of the limbs and with significant morbidity and mortality. Pharmacological and surgical inventions are not always effective. Cells from a varieties source have been shown to be capable of inducing angiogenesis and proved to be effective in alleviating patients’ symptoms after standard treatments have failed. Clinical benefits of cell therapies include improvement of ankle-brachial index, transcutaneous partial pressure of oxygen, reduction of pain, and decreased need for amputation. Currently used cells include mononuclear cells from bone marrow, peripheral blood and cord blood, hematopoietic stem cells, endothelial progenitor cells, and mesenchymal stem cells. Nonetheless, large randomized, placebo-controlled, double-blind studies involving homogenous patient populations are necessary to provide stronger safety and efficacy data on cell therapy. In addition, many challenges still exist, including optimization of cell types, dosing, and frequency of application.

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Author information

Authors and Affiliations

  1. Department of Laboratory Medicine, Fujian Medical University Union Hospital, Fuzhou, China

    Lianming Liao

  2. Department of Vascular Surgery, Xuan Wu Hospital of Capital Medical University, Beijing, China

    Yongquan Gu

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  1. Lianming Liao
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  2. Yongquan Gu
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Editor information

Editors and Affiliations

  1. Department of Surgery, Vascular Surgery Section, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Tulio Pinho Navarro

  2. Postgraduate Program in Sciences Applied to Surgery, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Lara Lellis Navarro Minchillo Lopes

  3. Vascular Biology and Therapeutics Program and the Departments of Surgery and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA

    Alan Dardik

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Liao, L., Gu, Y. (2021). Mesenchymal Stem Cell and Endothelial Progenitor Cell Transplantation for Buerger’s Disease. In: Navarro, T.P., Minchillo Lopes, L.L.N., Dardik, A. (eds) Stem Cell Therapy for Vascular Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-56954-9_11

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  • DOI: https://doi.org/10.1007/978-3-030-56954-9_11

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-56953-2

  • Online ISBN: 978-3-030-56954-9

  • eBook Packages: MedicineMedicine (R0)

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