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Molecular Diagnostics in Central Nervous System Infections

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Neurological Complications of Infectious Diseases

Part of the book series: Current Clinical Neurology ((CCNEU))

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Abstract

Central nervous system (CNS) infections can be life threatening if not diagnosed and treated early. The myriad clinical presentations of CNS infections can make a prompt diagnosis challenging. Multiple diagnostic modalities have been used in the past, including conventional microscopic examination, gram stain and cultures, antigen detection and serology, but these techniques have had major limitations - most notably in the diagnosis of viruses and other difficult to culture organisms. Advances in molecular diagnostics have largely replaced conventional techniques with a faster turnaround time and higher sensitivity and specificity. In this review we aim to summarize the currently available armamentarium of molecular assays, as well as their applications and limitations in diagnosing central nervous system infections.

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Authors and Affiliations

  1. Infectious Diseases Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Tamara Nawar & Anna Kaltsas

  2. Infectious Diseases Service, Clinical Microbiology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Yi-Wei Tang

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  1. UT Health McGovern Medical School, Houston, TX, USA

    Rodrigo Hasbun, MD MPH

  2. Div of Infectious Dis, MCN A-2200, Vanderbilt University, Nashville, TN, USA

    Karen C. Bloch, MD MPH

  3. Dept of Infectious Diseases, Apt 635, Cleveland Clinic Foundation, Cleveland, OH, USA

    Adarsh Bhimraj, MD

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Nawar, T., Kaltsas, A., Tang, YW. (2021). Molecular Diagnostics in Central Nervous System Infections. In: Hasbun, MD MPH, R., Bloch, MD MPH, K.C., Bhimraj, MD, A. (eds) Neurological Complications of Infectious Diseases. Current Clinical Neurology. Humana, Cham. https://doi.org/10.1007/978-3-030-56084-3_2

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