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Localization of Brain Tumors

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Principles of Neuro-Oncology

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Abstract

Localization in the clinical setting, is the diagnostic exercise of determining from the signs or symptoms of the patient what site of the nervous system is affected by the disease. A well-developed neurologic examination, after an extensive clinical interrogation of symptoms, should lead to localization in most cases. Syndromatic diagnoses leading to topographic and then to nosologic diagnosis is usually thought during medical formation. Topography refers to the area of the nervous system where the lesion or disease is localized. Some use the term localization indifferently with topographic diagnosis, but both refer to the determination of where in the nervous system is the lesion or damage. The aim of the present chapter is to present the most frequent localization of brain tumors, its clinical presentation, and their prognostic considerations.

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References

  1. GBD 2016 Brain and Other CNS Cancer Collaborators. Global, regional, and national burden of brain and other CNS cancer, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019 Apr;18(4):376–93.

    Google Scholar 

  2. Carpenter ER. Early diagnosis and localization of brain tumors. Radiology. 1926 Jan 1;6(1):67–70. https://doi.org/10.1148/6.1.67.

    Article  Google Scholar 

  3. Grant FC. Localization of brain tumors: by determination of the electrical resistance of the growth. JAMA. 1923 Dec 29;81(26):2169–72. https://doi.org/10.1001/jama.1923.02650260011004.

    Article  Google Scholar 

  4. Villanueva-Meyer JE, Mabray MC, Cha S. Current clinical brain tumor imaging. Neurosurgery. 2017 Sep 1;81(3):397–415.

    PubMed  PubMed Central  Google Scholar 

  5. Mullen KM, Huang RY. An update on the approach to the imaging of brain tumors. Curr Neurol Neurosci Rep. 2017 Jul;17(7):53.

    PubMed  Google Scholar 

  6. Cacho-Diaz B, Lorenzana-Mendoza NA, Reyes-Soto G, Hernandez-Estrada A, Monroy-Sosa A, Guraieb-Chahin P, et al. Lactate dehydrogenase as a prognostic marker in neoplastic meningitis. J Clin Neurosci Off J Neurosurg Soc Australas. 2018 May;51:39–42.

    CAS  Google Scholar 

  7. Ostrom QT, Gittleman H, Truitt G, Boscia A, Kruchko C, Barnholtz-Sloan JS. CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2011–2015. Neuro-Oncol. 2018 Oct 1;20(Suppl 4):iv1–86.

    PubMed  PubMed Central  Google Scholar 

  8. Buerki RA, Horbinski CM, Kruser T, Horowitz PM, James CD, Lukas RV. An overview of meningiomas. Future Oncol Lond Engl. 2018 Sep;14(21):2161–77.

    CAS  Google Scholar 

  9. Wiemels J, Wrensch M, Claus EB. Epidemiology and etiology of meningioma. J Neuro-Oncol. 2010 Sep;99(3):307–14.

    Google Scholar 

  10. Hottinger AF, Khakoo Y. Neurooncology of familial cancer syndromes. J Child Neurol. 2009 Dec;24(12):1526–35.

    PubMed  Google Scholar 

  11. Watts J, Box G, Galvin A, Brotchie P, Trost N, Sutherland T. Magnetic resonance imaging of meningiomas: a pictorial review. Insights Imaging. 2014 Feb;5(1):113–22.

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Rockhill J, Mrugala M, Chamberlain MC. Intracranial meningiomas: an overview of diagnosis and treatment. Neurosurg Focus. 2007;23(4):E1.

    PubMed  Google Scholar 

  13. Saha R, Jakhar K, Kumar R. Sphenoid wing meningioma presenting as cognitive impairment. Shanghai Arch Psychiatry. 2016 Jun 25;28(3):173–6.

    PubMed  PubMed Central  Google Scholar 

  14. Hoover JM, Morris JM, Meyer FB. Use of preoperative magnetic resonance imaging T1 and T2 sequences to determine intraoperative meningioma consistency. Surg Neurol Int. 2011;2:142.

    PubMed  PubMed Central  Google Scholar 

  15. Quinones-Hinojosa A, Kaprealian T, Chaichana KL, Sanai N, Parsa AT, Berger MS, et al. Pre-operative factors affecting resectability of giant intracranial meningiomas. Can J Neurol Sci J Can Sci Neurol. 2009 Sep;36(5):623–30.

    Google Scholar 

  16. Cain SA, Smoll NR, Van Heerden J, Tsui A, Drummond KJ. Atypical and malignant meningiomas: considerations for treatment and efficacy of radiotherapy. J Clin Neurosci Off J Neurosurg Soc Australas. 2015 Nov;22(11):1742–8.

    Google Scholar 

  17. Lake MG, Krook LS, Cruz SV. Pituitary adenomas: an overview. Am Fam Physician. 2013 Sep 1;88(5):319–27.

    PubMed  Google Scholar 

  18. Molitch ME. Diagnosis and treatment of pituitary adenomas: a review. JAMA. 2017 Feb 7;317(5):516–24.

    PubMed  Google Scholar 

  19. Gillam MP, Molitch ME, Lombardi G, Colao A. Advances in the treatment of prolactinomas. Endocr Rev. 2006 Aug;27(5):485–534.

    CAS  PubMed  Google Scholar 

  20. Freda PU, Beckers AM, Katznelson L, Molitch ME, Montori VM, Post KD, et al. Pituitary incidentaloma: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2011 Apr;96(4):894–904.

    CAS  PubMed  PubMed Central  Google Scholar 

  21. Rennert J, Doerfler A. Imaging of sellar and parasellar lesions. Clin Neurol Neurosurg. 2007 Feb;109(2):111–24.

    PubMed  Google Scholar 

  22. Webster J, Piscitelli G, Polli A, Ferrari CI, Ismail I, Scanlon MF. A comparison of cabergoline and bromocriptine in the treatment of hyperprolactinemic amenorrhea. Cabergoline Comparative Study Group. N Engl J Med. 1994 Oct 6;331(14):904–9.

    CAS  PubMed  Google Scholar 

  23. Colao A, Cappabianca P, Caron P, De Menis E, Farrall AJ, Gadelha MR, et al. Octreotide LAR vs. surgery in newly diagnosed patients with acromegaly: a randomized, open-label, multicentre study. Clin Endocrinol. 2009 May;70(5):757–68.

    Google Scholar 

  24. Hilton DA, Hanemann CO. Schwannomas and their pathogenesis. Brain Pathol Zurich Switz. 2014 Apr;24(3):205–20.

    Google Scholar 

  25. Kshettry VR, Hsieh JK, Ostrom QT, Kruchko C, Barnholtz-Sloan JS. Incidence of vestibular schwannomas in the United States. J Neuro-Oncol. 2015 Sep;124(2):223–8.

    Google Scholar 

  26. Matthies C, Samii M. Management of 1000 vestibular schwannomas (acoustic neuromas): clinical presentation. Neurosurgery. 1997 Jan;40(1):1–9.

    CAS  PubMed  Google Scholar 

  27. Halliday J, Rutherford SA, McCabe MG, Evans DG. An update on the diagnosis and treatment of vestibular schwannoma. Expert Rev Neurother. 2018 Jan;18(1):29–39.

    CAS  PubMed  Google Scholar 

  28. Muller HL. Craniopharyngioma. Handb Clin Neurol. 2014;124:235–53.

    PubMed  Google Scholar 

  29. Garnett MR, Puget S, Grill J, Sainte-Rose C. Craniopharyngioma. Orphanet J Rare Dis. 2007 Apr 10;2:18.

    PubMed  PubMed Central  Google Scholar 

  30. Chang CG, Kageyama N, Kobayashi T, Yoshida J, Negoro M. Pineal tumors: clinical diagnosis, with special emphasis on the significance of pineal calcification. Neurosurgery. 1981 Jun;8(6):656–68.

    CAS  PubMed  Google Scholar 

  31. Borit A, Blackwood W, Mair WG. The separation of pineocytoma from pineoblastoma. Cancer. 1980 Mar 15;45(6):1408–18.

    CAS  PubMed  Google Scholar 

  32. Chiechi MV, Smirniotopoulos JG, Mena H. Pineal parenchymal tumors: CT and MR features. J Comput Assist Tomogr. 1995 Aug;19(4):509–17.

    CAS  PubMed  Google Scholar 

  33. Korogi Y, Takahashi M, Ushio Y. MRI of pineal region tumors. J Neuro-Oncol. 2001 Sep;54(3):251–61.

    CAS  Google Scholar 

  34. Bruce JN, Stein BM. Surgical management of pineal region tumors. Acta Neurochir. 1995;134(3–4):130–5.

    CAS  PubMed  Google Scholar 

  35. Bakker SH, Jacobs WCH, Pondaag W, Gelderblom H, Nout RA, Dijkstra PDS, et al. Chordoma: a systematic review of the epidemiology and clinical prognostic factors predicting progression-free and overall survival. Eur Spine J Off Publ. 2018 Dec;27(12):3043–58.

    CAS  Google Scholar 

  36. Leah P, Dower A, Vescovi C, Mulcahy M, Al Khawaja D. Clinical experience of intracranial chordoma - a systematic review and meta-analysis of the literature. J Clin Neurosci Off J Neurosurg Soc Australas. 2018 Jul;53:6–12.

    CAS  Google Scholar 

  37. Beccaria K, Sainte-Rose C, Zerah M, Puget S. Paediatric Chordomas. Orphanet J Rare Dis. 2015 Sep 22;10:116.

    PubMed  PubMed Central  Google Scholar 

  38. Heery CR. Chordoma: the quest for better treatment options. Oncol Ther. 2016;4(1):35–51.

    PubMed  Google Scholar 

  39. Lapointe S, Perry A, Butowski NA. Primary brain tumours in adults. Lancet Lond Engl. 2018 Aug 4;392(10145):432–46.

    Google Scholar 

  40. Ostrom QT, Bauchet L, Davis FG, Deltour I, Fisher JL, Langer CE, et al. The epidemiology of glioma in adults: a “state of the science” review. Neuro-Oncol. 2014 Jul;16(7):896–913.

    CAS  PubMed  PubMed Central  Google Scholar 

  41. Rasmussen BK, Hansen S, Laursen RJ, Kosteljanetz M, Schultz H, Norgard BM, et al. Epidemiology of glioma: clinical characteristics, symptoms, and predictors of glioma patients grade I-IV in the the Danish neuro-oncology registry. J Neuro-Oncol. 2017 Dec;135(3):571–9.

    Google Scholar 

  42. Bauchet L, Ostrom QT. Epidemiology and molecular epidemiology. Neurosurg Clin N Am. 2019 Jan;30(1):1–16.

    PubMed  Google Scholar 

  43. Schwartzbaum JA, Fisher JL, Aldape KD, Wrensch M. Epidemiology and molecular pathology of glioma. Nat Clin Pract Neurol. 2006 Sep;2(9):494–503.

    PubMed  Google Scholar 

  44. Forst DA, Nahed BV, Loeffler JS, Batchelor TT. Low-grade gliomas. Oncologist. 2014 Apr;19(4):403–13.

    PubMed  PubMed Central  Google Scholar 

  45. de Groot JF. High-grade gliomas. Contin Minneap Minn. 2015 Apr;21(2):332–44.

    Google Scholar 

  46. Omuro A. Glioblastoma and other malignant gliomas. JAMA. 2013 Nov;310(17):1842–50.

    CAS  PubMed  Google Scholar 

  47. Weller M, Wick W, Aldape K, Brada M, Berger M, Pfister SM, et al. Glioma. Nat Rev Dis Primer. 2015 Jul 16;1:15017.

    Google Scholar 

  48. Wirsching H-G, Galanis E, Weller M. Glioblastoma. Handb Clin Neurol. 2016;134:381–97.

    PubMed  Google Scholar 

  49. Schiff D. Low-grade gliomas. Contin Minneap Minn. 2015 Apr;21(2):345–54.

    Google Scholar 

  50. Ohgaki H, Kleihues P. Epidemiology and etiology of gliomas. Acta Neuropathol (Berl). 2005 Jan;109(1):93–108.

    Google Scholar 

  51. Thakkar JP, Dolecek TA, Horbinski C, Ostrom QT, Lightner DD, Barnholtz-Sloan JS, et al. Epidemiologic and molecular prognostic review of glioblastoma. Cancer Epidemiol Biomark Prev. 2014 Sep;23(10):1985–96.

    CAS  Google Scholar 

  52. Posti JP, Bori M, Kauko T, Sankinen M, Nordberg J, Rahi M, et al. Presenting symptoms of glioma in adults. Acta Neurol Scand. 2015 Feb;131(2):88–93.

    CAS  PubMed  Google Scholar 

  53. Wesseling P, van den Bent M, Perry A. Oligodendroglioma: pathology, molecular mechanisms and markers. Acta Neuropathol (Berl). 2015 Jun;129(6):809–27.

    CAS  Google Scholar 

  54. Schomas DA, Laack NNI, Rao RD, Meyer FB, Shaw EG, O’Neill BP, et al. Intracranial low-grade gliomas in adults: 30-year experience with long-term follow-up at Mayo Clinic. Neuro-Oncol. 2009 Aug;11(4):437–45.

    PubMed  PubMed Central  Google Scholar 

  55. Smits A, Jakola AS. Clinical presentation, natural history, and prognosis of diffuse low-grade gliomas. Neurosurg Clin N Am. 2019 Jan;30(1):35–42.

    PubMed  Google Scholar 

  56. Amirian ES, Armstrong TS, Aldape KD, Gilbert MR, Scheurer ME. Predictors of survival among pediatric and adult ependymoma cases: a study using surveillance, epidemiology, and end results data from 1973 to 2007. Neuroepidemiology. 2012;39(2):116–24.

    PubMed  Google Scholar 

  57. Gerstner ER, Pajtler KW. Ependymoma. Semin Neurol. 2018 Feb;38(1):104–11.

    PubMed  Google Scholar 

  58. Metellus P, Guyotat J, Chinot O, Durand A, Barrie M, Giorgi R, et al. Adult intracranial WHO grade II ependymomas: long-term outcome and prognostic factor analysis in a series of 114 patients. Neuro-Oncol. 2010 Sep;12(9):976–84.

    PubMed  PubMed Central  Google Scholar 

  59. Van Den Bent MJ, Bromberg JEC, Buckner J. Low-grade and anaplastic oligodendroglioma. Handb Clin Neurol. 2016;134:361–80.

    Google Scholar 

  60. Ohgaki H, Kleihues P. The definition of primary and secondary glioblastoma. Clin Cancer Res Off J Am Assoc Cancer Res. 2013 Feb 15;19(4):764–72.

    CAS  Google Scholar 

  61. Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJB, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005 Mar;352(10):987–96.

    CAS  PubMed  Google Scholar 

  62. Hegi ME, Diserens A-C, Gorlia T, Hamou M-F, de Tribolet N, Weller M, et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med. 2005 Mar;352(10):997–1003.

    CAS  PubMed  Google Scholar 

  63. Hanif F, Muzaffar K, Perveen K, Malhi SM, Simjee SU. Glioblastoma Multiforme: a review of its epidemiology and pathogenesis through clinical presentation and treatment. Asian Pac J Cancer Prev. 2017 Jan 1;18(1):3–9.

    PubMed  PubMed Central  Google Scholar 

  64. Gladson CL, Prayson RA, Liu WM. The pathobiology of glioma tumors. Annu Rev Pathol Mech Dis. 2010 Jan;5(1):33–50.

    CAS  Google Scholar 

  65. Omar AI, Mason WP. Anaplastic astrocytomas. Handb Clin Neurol. 2012;105:451–66.

    PubMed  Google Scholar 

  66. Nayak L, Reardon DA. High-grade gliomas. Contin Minneap Minn. 2017 Dec;23(6):1548–63.

    Google Scholar 

  67. Lai A, Kharbanda S, Pope WB, Tran A, Solis OE, Peale F, et al. Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin. J Clin Oncol. 2011 Nov;29(34):4482–90.

    CAS  PubMed  PubMed Central  Google Scholar 

  68. Northcott PA, Robinson GW, Kratz CP, Mabbott DJ, Pomeroy SL, Clifford SC, et al. Medulloblastoma. Nat Rev Dis Primer. 2019 Feb 14;5(1):11.

    Google Scholar 

  69. Millard NE, De Braganca KC. Medulloblastoma. J Child Neurol. 2016 Oct;31(12):1341–53.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Neuro-oncology Unit, Instituto Nacional de Cancerología, Mexico City, Mexico

    Bernardo Cacho Díaz & Karen Salmerón-Moreno

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  1. Bernardo Cacho Díaz
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  2. Karen Salmerón-Moreno
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Editors and Affiliations

  1. Department of Neurosurgery, Aurora Neuroscience Innovation Institute, Milwaukee, WI, USA

    Alejandro Monroy-Sosa

  2. Department of Neurosurgery, Aurora Neuroscience Innovation Institute, Milwaukee, WI, USA

    Srikant S. Chakravarthi

  3. Instituto Nacional de Cancerología, Mexico City, Mexico

    Jaime G. de la Garza-Salazar

  4. Instituto Nacional de Cancerología, Mexico City, Mexico

    Abelardo Meneses Garcia

  5. Neeka Health, LLC, Milwaukee, WI, USA

    Amin B. Kassam

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Díaz, B.C., Salmerón-Moreno, K. (2021). Localization of Brain Tumors. In: Monroy-Sosa, A., Chakravarthi, S.S., de la Garza-Salazar, J.G., Meneses Garcia, A., Kassam, A.B. (eds) Principles of Neuro-Oncology. Springer, Cham. https://doi.org/10.1007/978-3-030-54879-7_12

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