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Dermatologic Adverse Effects of Anticancer Therapy I: General Principles

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Dermato-Oncology Study Guide

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Abstract

This chapter provides an overview of issues, concepts, and general approaches to caring for the patient experiencing dermatologic adverse effects of anticancer therapy. Reviewed are strategies and protocols for treating common symptoms and conditions experienced by these patients. Specific anticancer therapeutic classes are addressed in greater detail in the following three chapters.

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Abbreviations

ACTH:

Adrenocorticotropic hormone

AFND:

Acute febrile neutrophilic dermatosis (Sweet syndrome)

AGEP:

Acute generalized exanthematous pustulosis

AIDS:

Acquired immunodeficiency syndrome

ALK:

Anaplastic lymphoma kinase

ALL:

Acute lymphoblastic leukemia

AML:

Acute myeloid leukemia

APML:

Acute promyelocytic leukemia

ATG:

Antithymocyte globulin

ATRA:

All-trans retinoid acid

BTK:

Bruton tyrosine kinase

CLL:

Chronic lymphocytic leukemia

CML:

Chronic myelogenous leukemia

CMV:

Cytomegalovirus

CNS:

Central nervous system

CTCL:

Cutaneous T-cell lymphoma

DAE:

Dermatologic adverse effect

DMSO:

Dimethyl sulfoxide

DRESS:

Drug reaction with eosinophilia and systemic symptoms

FGFR:

Fibroblast growth factor receptor

GM-CSF:

Granulocyte macrophage colony-stimulating factor

GVHD:

Graft versus host disease

HBV:

Hepatitis B virus

HHV-8:

Human herpesvirus-8

HIF:

Hypoxia-inducible factor

HIV:

Human immunodeficiency virus

HPV:

Human papillomavirus

HSV:

Herpes simplex virus

IDH-2:

Isocitrate dehydrogenase-2

IL:

Interleukin

ILP:

Isolated limb perfusion

KA:

Keratoacanthoma

mTOR:

Mechanistic target of rapamycin

nbUVB:

Narrow band ultraviolet B

NEH:

Neutrophilic eccrine hidradenitis

NSAID:

Nonsteroidal anti-inflammatory drug

PABA:

Para-aminobenzoic acid

PARP:

Poly (ADP-ribose) polymerase

PCR:

Polymerase chain reaction

PDGFR:

Platelet-derived growth factor receptor

PDT:

Photodynamic therapy

PGF:

Placental growth factor

PI3K:

Phosphatidylinositol 3-kinase

PIH:

Postinflammatory hyperpigmentation

PKC:

Protein kinase C

RANKL:

Receptor activator of nuclear factor kappa-Î’ ligand

SCC:

Squamous cell carcinoma

SCF:

Stem cell factor

SCLE:

Subacute cutaneous lupus erythematosus

SDRIFE:

Symmetrical drug-related intertriginous and flexural exanthema

SJS:

Stevens-Johnson syndrome

SLAMF7:

Signaling lymphocytic activation molecule family member 7

SLE:

Systemic lupus erythematosus

SLL:

Small lymphocytic lymphoma

SNRI:

Serotonin-norepinephrine reuptake inhibitor

SSRI:

Selective serotonin reuptake inhibitor

TEN:

Toxic Epidermal Necrolysis

TLGLL:

T-cell large granular lymphocytic leukemia

T-PLL:

T-cell prolymphocytic leukemia

UPF:

Ultraviolet protection factor

UVR:

Ultraviolet radiation

VEGF:

Vascular endothelial growth factor

VEGFR:

Vascular endothelial growth factor receptor

VZV:

Varicella zoster virus

References

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Author information

Authors and Affiliations

  1. Santa Clara Valley Medical Center, San Jose, CA, USA

    Timothy Dang

  2. Department of Dermatology, University of Iowa Health Care, Iowa, IA, USA

    Vincent Liu

  3. Stanford Health Care; Stanford Medicine, Palo Alto, CA, USA

    Bernice Kwong

Authors
  1. Timothy Dang
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  2. Vincent Liu
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  3. Bernice Kwong
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Corresponding author

Correspondence to Timothy Dang .

Editor information

Editors and Affiliations

  1. Department of Dermatology, University of Iowa Health Care, Iowa, IA, USA

    Vincent Liu

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Dang, T., Liu, V., Kwong, B. (2021). Dermatologic Adverse Effects of Anticancer Therapy I: General Principles. In: Liu, V. (eds) Dermato-Oncology Study Guide. Springer, Cham. https://doi.org/10.1007/978-3-030-53437-0_8

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  • DOI: https://doi.org/10.1007/978-3-030-53437-0_8

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-53436-3

  • Online ISBN: 978-3-030-53437-0

  • eBook Packages: MedicineMedicine (R0)

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