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Endothelial Interactions and Coagulation

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Pediatric Critical Care

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Abstract

The endothelium comprises the inner cell lining of all blood vessels and is thus present in every organ in the body. With its continuous exposure to circulating blood components, it serves a vital role in sustaining nutrient perfusion to organs, local regulation of blood flow through vasodilation and vasoconstriction mediators, prevention of bleeding, aiding in localization of infection, preventing systemic spread, and delivery of mediators of tissue repair. In these roles, the endothelium interacts with a myriad of tissue based and circulating proteins and mediators involved in the fine regulation of microcirculatory flow, thrombosis, anti-thrombosis, clot lysis, immune signaling, pathogen elimination, and tissue repair.

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Author information

Authors and Affiliations

  1. Pediatric Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, USA

    Trung C. Nguyen

  2. Center for Translational Research on Inflammatory Diseases (CTRID) at the Michael E. DeBakey Veteran Administration Medical Center, Houston, TX, USA

    Trung C. Nguyen

  3. Pediatric Critical Care Medicine, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA

    Joseph A. Carcillo

Authors
  1. Trung C. Nguyen
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  2. Joseph A. Carcillo
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Corresponding author

Correspondence to Trung C. Nguyen .

Editor information

Editors and Affiliations

  1. Penn State Hershey Children’s Hospital, Pediatric Critical Care Medicine, Hershey, PA, USA

    Steven E. Lucking

  2. Division of Pediatric Critical Care, Department of Pediatrics, Janet Weis Children’s Hospital, Geisinger Medical Center, Danville, PA, USA

    Frank A. Maffei

  3. Department of Pediatrics/Divisions of Pediatric Critical and Palliative Care Medicine, Janet Weis Children’s Hospital at Geisinger, Geisinger Commonwealth School of Medicine, Danville, PA, USA

    Robert F. Tamburro

  4. Department of Pediatrics, Eastern Virginia Medical School, Children’s Hospital of The King’s Daughters, Norfolk, VA, USA

    Arno Zaritsky

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Nguyen, T.C., Carcillo, J.A. (2021). Endothelial Interactions and Coagulation. In: Lucking, S.E., Maffei, F.A., Tamburro, R.F., Zaritsky, A. (eds) Pediatric Critical Care . Springer, Cham. https://doi.org/10.1007/978-3-030-53363-2_3

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  • DOI: https://doi.org/10.1007/978-3-030-53363-2_3

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-53362-5

  • Online ISBN: 978-3-030-53363-2

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