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Genomics and Genetic Predisposition to Critical Illness in the Pediatric Intensive Care Unit

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Pediatric Critical Care

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Abstract

Much progress has been made in the past decade in the understanding of the genetic contribution to the development of human disease, in general, and critical care illness, specifically. With the mapping of the human genome and ongoing mapping of genetic polymorphisms and haplotypes in humans, the field of critical care is now in prime position to study the impact of genetics on common illnesses that affect children who require critical care, to examine how differences of the host defense response lead to variable outcomes in outwardly appearing similar disease states, and to study how genetic differences in response to therapy will help practitioners tailor therapeutic interventions to an individual child’s genetic composition. While we are still years away from true individualized medicine, we are now closer than ever to understanding why two children might respond to the same environmental insult in vastly different ways.

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Author information

Authors and Affiliations

  1. Pediatric Critical Care Medicine, Department of Pediatrics, University of Michigan, C.S. Mott Children’s Hospital, Ann Arbor, MI, USA

    Mary K. Dahmer & Michael W. Quasney

Authors
  1. Mary K. Dahmer
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  2. Michael W. Quasney
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Corresponding author

Correspondence to Mary K. Dahmer .

Editor information

Editors and Affiliations

  1. Penn State Hershey Children’s Hospital, Pediatric Critical Care Medicine, Hershey, PA, USA

    Steven E. Lucking

  2. Division of Pediatric Critical Care, Department of Pediatrics, Janet Weis Children’s Hospital, Geisinger Medical Center, Danville, PA, USA

    Frank A. Maffei

  3. Department of Pediatrics/Divisions of Pediatric Critical and Palliative Care Medicine, Janet Weis Children’s Hospital at Geisinger, Geisinger Commonwealth School of Medicine, Danville, PA, USA

    Robert F. Tamburro

  4. Department of Pediatrics, Eastern Virginia Medical School, Children’s Hospital of The King’s Daughters, Norfolk, VA, USA

    Arno Zaritsky

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Dahmer, M.K., Quasney, M.W. (2021). Genomics and Genetic Predisposition to Critical Illness in the Pediatric Intensive Care Unit. In: Lucking, S.E., Maffei, F.A., Tamburro, R.F., Zaritsky, A. (eds) Pediatric Critical Care . Springer, Cham. https://doi.org/10.1007/978-3-030-53363-2_1

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  • DOI: https://doi.org/10.1007/978-3-030-53363-2_1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-53362-5

  • Online ISBN: 978-3-030-53363-2

  • eBook Packages: MedicineMedicine (R0)

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