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Imaging Cardiac Metabolism

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Atlas of Nuclear Cardiology

Abstract

Cardiac metabolism refers to a complex system of interconnected chemical reactions. In broad terms, metabolism provides the energy for contraction and the materials for the heart’s structure and function. A defining feature of metabolism is the flux of chemical compounds that can be traced by physical methods, including radioactive decay of tracers or magnetic resonance spectroscopy. Metabolic activity is a dynamic process found only in living cells and tissues. In addition to the dynamic nature of metabolic activity, intermediary metabolites also control cell function, either as regulators of enzyme activity or as posttranslational modifiers of protein function and transcriptional activity. An important recent development in the field of nuclear cardiology is the concept that metabolic remodeling of the heart precedes, triggers, and sustains structural and functional remodeling, and that metabolism is inextricably linked to both physiology and molecular biology of the heart. This concept offers unprecedented opportunities for metabolic imaging.

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Author information

Authors and Affiliations

  1. The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA

    Heinrich Taegtmeyer

  2. University of Maryland School of Medicine, Baltimore, MD, USA

    Vasken Dilsizian

Authors
  1. Heinrich Taegtmeyer
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  2. Vasken Dilsizian
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Correspondence to Heinrich Taegtmeyer .

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Editors and Affiliations

  1. University of Maryland School of Medicine, Baltimore, MD, USA

    Vasken Dilsizian

  2. Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Jagat Narula

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Taegtmeyer, H., Dilsizian, V. (2021). Imaging Cardiac Metabolism. In: Dilsizian, V., Narula, J. (eds) Atlas of Nuclear Cardiology. Springer, Cham. https://doi.org/10.1007/978-3-030-49885-6_9

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  • DOI: https://doi.org/10.1007/978-3-030-49885-6_9

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  • Publisher Name: Springer, Cham

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