Abstract
The application of a radiotracer technique to measure physiologic parameters, such as pulmonary circulation, dates back to 1927. Despite considerable advances in the application of radiotracer technique for interrogating physiologic and pathophysiologic cardiopulmonary conditions in the early twentieth century, the spatial resolution of the scintigraphic instruments used to measure tracer concentration in the heart, lungs, and blood was limited. The advent of single-photon emission CT (SPECT) in the late 1970s and positron emission tomography (PET) in the 1980s dramatically changed the clinical utility of radiotracer technique for the assessment of myocardial perfusion, viability, and function.
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Dilsizian, V. (2021). SPECT and PET Myocardial Perfusion Imaging: Tracers and Techniques. In: Dilsizian, V., Narula, J. (eds) Atlas of Nuclear Cardiology. Springer, Cham. https://doi.org/10.1007/978-3-030-49885-6_4
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