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Engineering Perspectives for Mechanical Circulatory Support Devices

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Mechanical Support for Heart Failure

Abstract

The design and development of mechanical circulatory support (MCS) devices involves interaction with the native circulation and engineering fundamentals such as converting electrical energy to hydraulic energy and stabilization by negative feedback. Pump type determines output characteristics, and among continuous flow pumps, the relationships between pressure head and motor power and flow rate offer clinical insight, such as sensorless flow estimation and ventricular suction detection. Pump and equipment design considerations affect efficiency and hemocompatibility; development practices enable transferring such medical devices to patients.

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References

  1. Katz AM. Heart failure pathophysiology, molecular biology, and clinical management. Philadelphia: Lippincott Williams & Wilkins; 2000. p. 41–4.

    Google Scholar 

  2. Schampaert S, Rutten MC, et al. Modeling the interaction between the intra-aortic balloon pump and the cardiovascular system: the effect of timing. ASAIO J. 2013;59(1):30–6. https://doi.org/10.1097/MAT.0b013e3182768ba9.

    Article  PubMed  Google Scholar 

  3. Slaughter MS, Rogers JG, Milano CA, Russell SD, Conte JV, Feldman D, et al. Advanced heart failure treated with continuous-flow left ventricular assist device. N Engl J Med. 2009;361(23):2241–51. https://doi.org/10.1056/NEJMoa0909938.

    Article  CAS  PubMed  Google Scholar 

  4. Griffith BP, Kormos RL, Borovetz HS, Litwak K, Antaki JF, Poirier VL, et al. HeartMate II left ventricular assist system: from concept to first clinical use. Ann Thorac Surg. 2001;71(3 Suppl):S116–20; discussion S114–6.

    Article  CAS  Google Scholar 

  5. Selzman CH, Koliopoulou A, Glotzbach JP, McKellar SH. Evolutionary improvements in the Jarvik 2000 left ventricular assist device. ASAIO J. 2018;64(6):827–30. https://doi.org/10.1097/MAT.0000000000000743.

    Article  PubMed  Google Scholar 

  6. Chung MK, Zhang N, Tansley GD, Woodard JC. Impeller behavior and displacement of the VentrAssist implantable rotary blood pump. Artif Organs. 2004;28(3):287–97.

    Article  Google Scholar 

  7. Larose JA, Tamez D, Ashenuga M, Reyes C. Design concepts and principle of operation of the HeartWare ventricular assist system. ASAIO J. 2010;56(4):285–9. https://doi.org/10.1097/MAT.0b013e3181dfbab5.

    Article  PubMed  Google Scholar 

  8. Morshuis M, Schoenbrodt M, Nojiri C, Roefe D, Schulte-Eistrup S, Boergermann J, et al. DuraHeart magnetically levitated centrifugal left ventricular assist system for advanced heart failure patients. Expert Rev Med Devices. 2010;7(2):173–83. https://doi.org/10.1586/erd.09.68.

    Article  PubMed  Google Scholar 

  9. Bourque K, Cotter C, Dague C, Harjes D, Dur O, Duhamel J, et al. Design rationale and preclinical evaluation of the HeartMate 3 left ventricular assist system for hemocompatibilitY. ASAIO J. 2016;62(4):375–83. https://doi.org/10.1097/MAT.0000000000000388.

    Article  CAS  PubMed  Google Scholar 

  10. Mironer A. Engineering fluid mechanics. New York: McGraw-Hill; 1979. p. 213.

    Google Scholar 

  11. Guyton AC, Hall JE. Textbook of medical physiology. 11th ed. Philadelphia: Elsevier Saunders; 2006. p. 232–3.

    Google Scholar 

  12. Arnold WS, Bourque K. The engineer and the clinician: understanding the work output and troubleshooting of the HeartMate II rotary flow pump. J Thorac Cardiovasc Surg. 2013;145(1):32–6. https://doi.org/10.1016/j.jtcvs.2012.07.113.

    Article  PubMed  Google Scholar 

  13. Maltais S, Kilic A, Nathan S, Keebler M, Emani S, Ransom J, et al. PREVENtion of HeartMate II pump thrombosis through clinical management: the PREVENT multi-center study. J Heart Lung Transplant. 2017;36(1):1–12. https://doi.org/10.1016/j.healun.2016.10.001.

    Article  PubMed  Google Scholar 

  14. Stepanoff AJ. Centrifugal and axial flow pumps. 2nd ed. Florida: Krieger; 1957.

    Google Scholar 

  15. Uriel N, Colombo PC, Cleveland JC, Long JW, Salerno C, Goldstein DJ, et al. Hemocompatibility-related outcomes in the MOMENTUM 3 trial at 6 months: a randomized controlled study of a fully magnetically levitated pump in advanced heart failure. Circulation. 2017;135(21):2003–12. https://doi.org/10.1161/CIRCULATIONAHA.117.028303.

    Article  PubMed  Google Scholar 

  16. Quality System (QS) Regulation/Medical Device Good Manufacturing Practices, 21 C.F.R. Part 820 (1978).

    Google Scholar 

  17. Regulation (EU) 2017/745 of the European Parliament and of the Council of 5 April 2017 on medical devices, amending Directive 2001/83/EC, Regulation (EC) No 178/2002 and Regulation (EC) No 1223/2009 and repealing Council Directives 90/385/EEC and 93/42/EEC (2017).

    Google Scholar 

  18. American National Standards Institute. Human factors engineering – Design of medical devices. Virginia: ANSI/AAMI/HE75:2009 (r2013).

    Google Scholar 

  19. International Organization for Standardization. Medical Devices – Application of usability engineering to medical devices. Switzerland: ISO/IEC 62366:2007.

    Google Scholar 

  20. U.S. Food and Drug Administration. Guidance for Industry: Applying human factors and usability engineering to optimize medical device design. Maryland: The Administration; 2016.

    Google Scholar 

  21. American National Standards Institute. Medical Devices – Application of risk management to medical devices. Virginia: ANSI/AAMI/ISO 14971:2007 (r2010).

    Google Scholar 

  22. Rogers JG, Pagani FD, Tatooles AJ, Bhat G, Slaughter MS, Birks EJ, et al. Intrapericardial left ventricular assist device for advanced heart failure. N Engl J Med. 2017;376(5):451–60. https://doi.org/10.1056/NEJMoa1602954.

    Article  PubMed  Google Scholar 

  23. Mehra MR, Goldstein DJ, Uriel N, Cleveland JC Jr, Yuzefpolskaya M, Salerno C, et al. Two-year outcomes with a magnetically levitated cardiac pump in heart failure. N Engl J Med. 2018;378(15):1386–95. https://doi.org/10.1056/NEJMoa1800866.

    Article  PubMed  Google Scholar 

  24. Zimpfer D, Strueber M, Aigner P, Schmitto JD, Fiane AE, Larbalestier R, et al. Evaluation of the HeartWare ventricular assist device Lavare cycle in a particle image velocimetry model and in clinical practice. Eur J Cardiothorac Surg. 2016;50(5):839–48.

    Article  Google Scholar 

  25. Bourque K, Dague C, Farrar D, Harms K, Tamez D, Cohn W, Tuzun E, Poirier V, Frazier OH. In vivo assessment of a rotary left ventricular assist device-induced artificial pulse in the proximal and distal aorta. Artif Organs. 2006;30(8):638–42.

    Article  Google Scholar 

  26. Desai AS, Bhimaraj A, Bharmi R, Jermyn R, Bhatt K, Shavelle D, et al. Ambulatory hemodynamic monitoring reduces heart failure hospitalizations in “Real-World” clinical practice. J Am Coll Cardiol. 2017;69(19):2357–65. https://doi.org/10.1016/j.jacc.2017.03.009.

    Article  PubMed  Google Scholar 

  27. Schmitto JD, Hanke JS, Rojas SV, Avsar M, Haverich A, et al. First implantation in man of a new magnetically levitated left ventricular assist device (HeartMate III). J Heart Lung Transplant. 2015;34(6):858–60.

    Article  Google Scholar 

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Disclosures

The authors are employees of Abbott.

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Authors and Affiliations

  1. Abbott, Burlington, MA, USA

    Kevin Bourque MSME, Christopher Cotter MSME & Charles Dague MSEE

Authors
  1. Kevin Bourque MSME
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  2. Christopher Cotter MSME
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  3. Charles Dague MSEE
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Corresponding author

Correspondence to Kevin Bourque MSME .

Editor information

Editors and Affiliations

  1. Lerner Research Institute, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University Cleveland Clinic, Cleveland, OH, USA

    Jamshid H. Karimov

  2. Lerner Research Institute, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University Cleveland Clinic, Cleveland, OH, USA

    Kiyotaka Fukamachi

  3. Kaufman Center for Heart Failure Heart, Thoracic, and Vascular Institute, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University Cleveland Clinic, Cleveland, OH, USA

    Randall C. Starling

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Bourque, K., Cotter, C., Dague, C. (2020). Engineering Perspectives for Mechanical Circulatory Support Devices. In: Karimov, J., Fukamachi, K., Starling, R. (eds) Mechanical Support for Heart Failure . Springer, Cham. https://doi.org/10.1007/978-3-030-47809-4_8

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  • DOI: https://doi.org/10.1007/978-3-030-47809-4_8

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-47808-7

  • Online ISBN: 978-3-030-47809-4

  • eBook Packages: MedicineMedicine (R0)

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