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Immune Mechanisms in Vascular Remodeling in Hypertension

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Microcirculation in Cardiovascular Diseases

Part of the book series: Updates in Hypertension and Cardiovascular Protection ((UHCP))

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Abstract

Small resistance arteries undergo either inward eutrophic or hypertrophic remodeling, which contributes to raise blood pressure and impairs tissue perfusion. Vasoconstriction, growth, oxidative stress, and inflammation are mechanisms in the vascular wall that participate in vascular remodeling. Inflammatory and immune cells infiltrating the adventitia and perivascular fat produce cytokines that contribute to vascular injury. Molecular studies may identify diagnostic and therapeutic targets in the future that will improve our ability to prevent and treat vascular injury associated with hypertension and cardiovascular disease.

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Acknowledgments

The work of the author was supported by Canadian Institutes of Health Research (CIHR) grants 37917, 82790, 102606, and 123465 and by the Canada Fund for Innovation and currently by the First Pilot Foundation Grant 143348 from the CIHR and by a Canada Research Chair (CRC) on Hypertension and Vascular Research from the CIHR/Government of Canada CRC Program.

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Authors and Affiliations

  1. Department of Medicine, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, QC, Canada

    Ernesto L. Schiffrin

  2. Hypertension and Vascular Research Unit, Lady Davis Institute for Medical Research, McGill University, Montreal, QC, Canada

    Ernesto L. Schiffrin

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  1. Ernesto L. Schiffrin
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Correspondence to Ernesto L. Schiffrin .

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Editors and Affiliations

  1. Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy

    Enrico Agabiti-Rosei

  2. Division of Cardiovascular Sciences School of Medical Sciences, University of Manchester, Manchester, UK

    Anthony M. Heagerty

  3. Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy

    Damiano Rizzoni

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Schiffrin, E.L. (2020). Immune Mechanisms in Vascular Remodeling in Hypertension. In: Agabiti-Rosei, E., Heagerty, A.M., Rizzoni, D. (eds) Microcirculation in Cardiovascular Diseases. Updates in Hypertension and Cardiovascular Protection. Springer, Cham. https://doi.org/10.1007/978-3-030-47801-8_7

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  • DOI: https://doi.org/10.1007/978-3-030-47801-8_7

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