Skip to main content

Can Frailty and Sarcopenia Be Mitigated in Lung Resection Candidates?

  • Chapter
  • First Online:
Difficult Decisions in Thoracic Surgery

Part of the book series: Difficult Decisions in Surgery: An Evidence-Based Approach ((DDSURGERY))

  • 602 Accesses

Abstract

Frailty or sarcopenia are present in a large percentage of the elderly and are associated with a number of adverse outcomes after lung resection. These include an increased risk of postoperative complications, prolonged hospital length of stay, an increased frequency of discharge to other than home, increased costs of care, and decreased long-term survival. There is growing evidence that the negative effects of frailty on surgical outcomes can be mitigated by preoperative exercise, including respiratory muscle training, resistance training, and improving stamina. Most randomized trials demonstrate an improvement in exercise capacity associated with an exercise intervention, even in as little as 1 week. Preoperative exercise is associated with improved postoperative outcomes, most commonly a reduction in pulmonary complications and shortened length of hospital stay. A preoperative exercise program is recommended for patients who are at increased risk for complications after lung resection.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Bandeen-Roche K, Seplaki CL, Huang J, Buta B, Kalyani RR, Varadhan R, Xue QL, Walston JD, Kasper JD. Frailty in older adults: a nationally representative profile in the United States. J Gerontol A Biol Sci Med Sci. 2015;70(11):1427–34.

    Article  Google Scholar 

  2. Beckert AK, Huisingh-Scheetz M, Thompson K, Celauro AD, Williams J, Pachwicewicz P, Ferguson MK. Screening for frailty in thoracic surgical patients. Ann Thorac Surg. 2017;103(3):956–61.

    Article  Google Scholar 

  3. Cruz-Jentoft AJ, Landi F, Schneider SM, Zúñiga C, Arai H, Boirie Y, Chen LK, Fielding RA, Martin FC, Michel JP, Sieber C, Stout JR, Studenski SA, Vellas B, Woo J, Zamboni M, Cederholm T. Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS). Age Ageing. 2014;43(6):748–59.

    Article  Google Scholar 

  4. Tsiouris A, Hammoud ZT, Velanovich V, Hodari A, Borgi J, Rubinfeld I. A modified frailty index to assess morbidity and mortality after lobectomy. J Surg Res. 2013;183(1):40–6.

    Article  Google Scholar 

  5. Ruiz J, Miller AA, Tooze JA, Crane S, Petty WJ, Gajra A, Klepin HD. Frailty assessment predicts toxicity during first cycle chemotherapy for advanced lung cancer regardless of chronologic age. J Geriatr Oncol. 2019;10(1):48–54.

    Article  Google Scholar 

  6. Raghavan G, Shaverdian N, Chan S, Chu FI, Lee P. Comparing outcomes of patients with early-stage non-small-cell lung cancer treated with stereotactic body radiotherapy based on frailty status. Clin Lung Cancer. 2018;19(5):e759–66.

    Article  Google Scholar 

  7. Nakamura R, Inage Y, Tobita R, Yoneyama S, Numata T, Ota K, Yanai H, Endo T, Inadome Y, Sakashita S, Satoh H, Yuzawa K, Terashima T. Sarcopenia in resected NSCLC: effect on postoperative outcomes. J Thorac Oncol. 2018;13(7):895–903.

    Article  Google Scholar 

  8. Burtin C, Bezuidenhout J, Sanders KJC, Dingemans AC, Schols AMWJ, Peeters STH, Spruit MA, De Ruysscher DKM. Handgrip weakness, low fat-free mass, and overall survival in non-small cell lung cancer treated with curative-intent radiotherapy. J Cachexia Sarcopenia Muscle. 2020;11:424–31. https://doi.org/10.1002/jcsm.12526.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Cortellini A, Verna L, Porzio G, Bozzetti F, Palumbo P, Masciocchi C, Cannita K, Parisi A, Brocco D, Tinari N, Ficorella C. Predictive value of skeletal muscle mass for immunotherapy with nivolumab in non-small cell lung cancer patients: a “hypothesis-generator” preliminary report. Thorac Cancer. 2019;10(2):347–51.

    Article  CAS  Google Scholar 

  10. Tsukagoshi M, Yokobori T, Yajima T, Maeno T, Shimizu K, Mogi A, Araki K, Harimoto N, Shirabe K, Kaira K. Skeletal muscle mass predicts the outcome of nivolumab treatment for non-small cell lung cancer. Medicine (Baltimore). 2020;99(7):e19059.

    Article  CAS  Google Scholar 

  11. Pehlivan E, Turna A, Gurses A, Gurses HN. The effects of preoperative short-term intense physical therapy in lung cancer patients: a randomized controlled trial. Ann Thorac Cardiovasc Surg. 2011;17(5):461–8.

    Article  Google Scholar 

  12. Stefanelli F, Meoli I, Cobuccio R, Curcio C, Amore D, Casazza D, Tracey M, Rocco G. High-intensity training and cardiopulmonary exercise testing in patients with chronic obstructive pulmonary disease and non-small-cell lung cancer undergoing lobectomy. Eur J Cardiothorac Surg. 2013;44(4):e260–5.

    Article  Google Scholar 

  13. Gao K, Yu PM, Su JH, He CQ, Liu LX, Zhou YB, Pu Q, Che GW. Cardiopulmonary exercise testing screening and pre-operative pulmonary rehabilitation reduce postoperative complications and improve fast-track recovery after lung cancer surgery: a study for 342 cases. Thorac Cancer. 2015;6(4):443–9.

    Article  Google Scholar 

  14. Licker M, Karenovics W, Diaper J, Frésard I, Triponez F, Ellenberger C, Schorer R, Kayser B, Bridevaux PO. Short-term preoperative high-intensity interval training in patients awaiting lung cancer surgery: a randomized controlled trial. J Thorac Oncol. 2017;12(2):323–33.

    Article  Google Scholar 

  15. Lai Y, Huang J, Yang M, Su J, Liu J, Che G. Seven-day intensive preoperative rehabilitation for elderly patients with lung cancer: a randomized controlled trial. J Surg Res. 2017;209:30–6.

    Article  Google Scholar 

  16. Huang J, Lai Y, Zhou X, Li S, Su J, Yang M, Che G. Short-term high-intensity rehabilitation in radically treated lung cancer: a three-armed randomized controlled trial. J Thorac Dis. 2017;9(7):1919–29.

    Article  Google Scholar 

  17. Lai Y, Su J, Qiu P, Wang M, Zhou K, Tang Y, Che G. Systematic short-term pulmonary rehabilitation before lung cancer lobectomy: a randomized trial. Interact Cardiovasc Thorac Surg. 2017;25(3):476–83.

    Article  Google Scholar 

  18. Boujibar F, Bonnevie T, Debeaumont D, Bubenheim M, Cuvellier A, Peillon C, Gravier FE, Baste JM. Impact of prehabilitation on morbidity and mortality after pulmonary lobectomy by minimally invasive surgery: a cohort study. J Thorac Dis. 2018;10(4):2240–8.

    Article  Google Scholar 

  19. Bhatia C, Kayser B. Preoperative high-intensity interval training is effective and safe in deconditioned patients with lung cancer: a randomized clinical trial. J Rehabil Med. 2019;51(9):712–8.

    Article  Google Scholar 

  20. Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc. 1982;14(5):377–81.

    Article  CAS  Google Scholar 

  21. Pouwels S, Fiddelaers J, Teijink JA, Woorst JF, Siebenga J, Smeenk FW. Preoperative exercise therapy in lung surgery patients: a systematic review. Respir Med. 2015;109(12):1495–504.

    Article  Google Scholar 

  22. Ni HJ, Pudasaini B, Yuan XT, Li HF, Shi L, Yuan P. Exercise training for patients pre- and postsurgically treated for non-small cell lung cancer: a systematic review and meta-analysis. Integr Cancer Ther. 2017;16(1):63–73.

    Article  Google Scholar 

  23. Sebio Garcia R, Yáñez Brage MI, Giménez Moolhuyzen E, Granger CL, Denehy L. Functional and postoperative outcomes after preoperative exercise training in patients with lung cancer: a systematic review and meta-analysis. Interact Cardiovasc Thorac Surg. 2016;23(3):486–97.

    Article  Google Scholar 

  24. Steffens D, Beckenkamp PR, Hancock M, Solomon M, Young J. Preoperative exercise halves the postoperative complication rate in patients with lung cancer: a systematic review of the effect of exercise on complications, length of stay and quality of life in patients with cancer. Br J Sports Med. 2018;52(5):344.

    Article  Google Scholar 

  25. Li X, Li S, Yan S, Wang Y, Wang X, Sihoe ADL, Yang Y, Wu N. Impact of preoperative exercise therapy on surgical outcomes in lung cancer patients with or without COPD: a systematic review and meta-analysis. Cancer Manag Res. 2019;11:1765–77.

    Article  Google Scholar 

  26. Rosero ID, Ramírez-Vélez R, Lucia A, Martínez-Velilla N, Santos-Lozano A, Valenzuela PL, Morilla I, Izquierdo M. Systematic review and meta-analysis of randomized, controlled trials on preoperative physical exercise interventions in patients with non-small-cell lung cancer. Cancers. 2019;11:944.

    Article  CAS  Google Scholar 

  27. Abellan van Kan G, Rolland Y, Bergman H, et al. The I.A.N.A. Task Force on frailty assessment of older people in clinical practice. J Nutr Health Aging. 2008;12:29–37.

    Article  CAS  Google Scholar 

  28. Dent E, Morley JE, Cruz-Jentoft AJ, Arai H, Kritchevsky SB, Guralnik J, Bauer JM, Pahor M, Clark BC, Cesari M, Ruiz J, Sieber CC, Aubertin-Leheudre M, Waters DL, Visvanathan R, Landi F, Villareal DT, Fielding R, Won CW, Theou O, Martin FC, Dong B, Woo J, Flicker L, Ferrucci L, Merchant RA, Cao L, Cederholm T, SML R, Rodríguez-Mañas L, Anker SD, Lundy J, Gutiérrez Robledo LM, Bautmans I, Aprahamian I, JMGA S, Izquierdo M, Vellas B. International clinical practice guidelines for sarcopenia (ICFSR): screening, diagnosis and management. J Nutr Health Aging. 2018;22(10):1148–61.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mark K. Ferguson .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Ferguson, M.K. (2020). Can Frailty and Sarcopenia Be Mitigated in Lung Resection Candidates?. In: Ferguson, M. (eds) Difficult Decisions in Thoracic Surgery. Difficult Decisions in Surgery: An Evidence-Based Approach. Springer, Cham. https://doi.org/10.1007/978-3-030-47404-1_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-47404-1_10

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-47403-4

  • Online ISBN: 978-3-030-47404-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics