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Laser Interstitial Thermal Therapy for Brain Metastasis

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Radiotherapy in Managing Brain Metastases

Abstract

Current strategies for the treatment of metastatic brain tumors include surgical resection or ablation, stereotactic radiosurgery, fractionated radiation therapy, whole brain radiation therapy (WBRT), and in select cases, targeted medical therapy. Though the treatment of intracranial metastatic tumors has improved significantly over the last two decades, there is still a large subset of patients who do not respond to treatment. Laser interstitial thermal therapy (LITT) is a novel, highly focused, minimally invasive technique that can be used to treat a variety of solid organ tumors. After decades of struggles, LITT established its place in the neurosurgeon’s armamentarium. This has been made possible by the utilization of recent advances in imaging technology like MR thermography. Proper patient selection for the appropriate indication is of utmost importance in ensuring the success of LITT. In this chapter, we review the current literature on the role of LITT in treatment of brain metastases and discuss its role in treating this difficult entity.

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Authors and Affiliations

  1. Department of Neurosurgery, Rose Ella Burkhardt Neuro-Oncology Center, Cleveland Clinic Foundation, Cleveland, OH, USA

    Ahmet F. Atik, Krishna C. Joshi, Alireza Mohammad Mohammadi & Gene H. Barnett

  2. Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA

    Gene H. Barnett

Authors
  1. Ahmet F. Atik
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  2. Krishna C. Joshi
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  3. Alireza Mohammad Mohammadi
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  4. Gene H. Barnett
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Corresponding author

Correspondence to Ahmet F. Atik .

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Editors and Affiliations

  1. Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Yoshiya Yamada

  2. Department of Radiation Oncology, University of Southern California, Los Angeles, CA, USA

    Eric Chang

  3. Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL, USA

    John B. Fiveash

  4. Weill Cornell Medicine, NewYork–Presbyterian Hospital, New York, NY, USA

    Jonathan Knisely

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Atik, A.F., Joshi, K.C., Mohammadi, A.M., Barnett, G.H. (2020). Laser Interstitial Thermal Therapy for Brain Metastasis. In: Yamada, Y., Chang, E., Fiveash, J., Knisely, J. (eds) Radiotherapy in Managing Brain Metastases. Springer, Cham. https://doi.org/10.1007/978-3-030-43740-4_7

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  • DOI: https://doi.org/10.1007/978-3-030-43740-4_7

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