Abstract
This contribution describes the strategy of a one-layer Transdermal Drug Delivery System (TDDS) device, where a hydrogel acts both as a drug delivery system and a Pressure Sensitive Adhesive (PSA), differing from the most well-known TDDS, where the device is essentially comprised of a drug reservoir with a protective outer cover, a permeable membrane, an adhesive, and a release liner.
Accordingly, we have synthesized conventional poly(acrylamide-co-hydroxyethyl methacrylate) [P(AM-HEMA)] hydrogels and nanocomposite hydrogels filled with poly(styrène-co-butyl acrylate) nanoparticles [P(AM-HEMA)-PSBuA]. PSBuA nanoparticles were synthesized by direct emulsion polymerization. P(AM-HEMA) hydrogels with HEMA content of 10 and 20 mol% and those filled with 26 wt.% of PSBuA nanoparticles were prepared by a free radical polymerization in aqueous medium using N, N’-methylene-bis-acrylamide (Bis) and potassium persulfate as cross-linking agent and initiator respectively. Hydrogels adhesive properties were evaluated when they were applied to different substrates, equivalent human skin and stainless steel, using a probe tack test. These properties were studied as functions of the chemical composition of the hydrogel and the nature of the substrate. The adhesion energy was found to be related to the chemical composition and the rheological properties of the hydrogels which were also evaluated by the determination of elastic G’ and loss G” moduli derived from oscillatory shearing measurements performed in the linear domain.
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Baït, N., Grassl, B., Derail, C., Benaboura, A. (2020). Hydrogels with Enhenced Adhesive and Rheological Properties for Transdermal Drug Delivery Systems Design. In: Benmounah, A., Abadlia, M.T., Saidi, M., Zerizer, A. (eds) Proceedings of the 4th International Symposium on Materials and Sustainable Development. ISMSD 2019. Springer, Cham. https://doi.org/10.1007/978-3-030-43268-3_1
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