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The IL-17/Th17 Axis as a Therapeutic Target in Periodontitis

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Emerging Therapies in Periodontics

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Abstract

The Th17/IL-17 axis has been implicated in the pathogenesis of several inflammatory and autoimmune diseases including psoriasis, rheumatoid arthritis, and periodontitis. Indeed, in periodontitis, recent studies have further highlighted the role of the Th17/IL-17 axis in mediating immunopathology underscoring this pathway as a plausible therapeutic target for this disease. In this chapter, we focused not only on the role of IL-17A during immunopathology but also on its protective roles at mucosal barrier sites. We discussed the role of Th17 cells and IL-17A in oral mucosa homeostasis, their regulation and role in periodontal immunopathology. Finally, we reviewed the currently used agents for the management of Th17/IL-17 mediated diseases and commented on their possible use in the treatment of periodontitis.

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Acknowledgments

This work was partly funded by the Chilean government through FONDECYT # 11180389 (to N.D) and FONDECYT # 11180505 (to L.A).

Author information

Authors and Affiliations

  1. Laboratory of Oral Microbiology and Laboratory for Craniofacial Translational Research, Faculty of Dentistry, University of Chile, Santiago, Chile

    Nicolas Dutzan & Loreto Abusleme

  2. Oral Immunity and Inflammation Unit, NIDCR, NIH, Bethesda, MD, USA

    Niki Moutsopoulos

Authors
  1. Nicolas Dutzan
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  2. Loreto Abusleme
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  3. Niki Moutsopoulos
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Corresponding author

Correspondence to Nicolas Dutzan .

Editor information

Editors and Affiliations

  1. School of Dental Medicine, Department of Periodontics, University of Pennsylvania, Philadelphia, PA, USA

    Sinem Esra Sahingur

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Dutzan, N., Abusleme, L., Moutsopoulos, N. (2020). The IL-17/Th17 Axis as a Therapeutic Target in Periodontitis. In: Sahingur, S. (eds) Emerging Therapies in Periodontics. Springer, Cham. https://doi.org/10.1007/978-3-030-42990-4_6

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  • DOI: https://doi.org/10.1007/978-3-030-42990-4_6

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-42989-8

  • Online ISBN: 978-3-030-42990-4

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