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Resolvins in Periodontal Tissue Homeostasis (Emerging Therapies)

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Emerging Therapies in Periodontics

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Abstract

Periodontitis is a multifactorial chronic inflammatory disease of bacterial etiology. It is characterized by dysbiosis of the oral microbiome that is linked to chronic unresolved inflammation and destruction of the periodontal tissues. Recent studies suggest that the uncontrolled inflammation and tissue destruction associated with periodontitis is due to a failure of endogenous resolution of inflammation pathways. In this review, pro-resolution mediators and resolution of inflammation pathways will be discussed in the context of tissue homeostasis. In addition, emerging therapies using resolvins for the successful management of inflammatory ailments and as a treatment paradigm for periodontal disease will be emphasized. Pro-resolution mediators, such as resolvins, hold great promise in the treatment of periodontitis, including periodontal tissue regeneration.

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Acknowledgments

This work was supported in part by NIH-NIDCR R01-DE025020 and NIH-NIDCR T90-DE026110.

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Authors and Affiliations

  1. The Forsyth Institute, Cambridge, MA, USA

    Audrey Rakian, Rubie Rakian, Nada Alshehri & Thomas E. Van Dyke

  2. Department of Preventive Dental Sciences, College of Dentistry, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia

    Nada Alshehri

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  1. Audrey Rakian
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  2. Rubie Rakian
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  4. Thomas E. Van Dyke
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Correspondence to Thomas E. Van Dyke .

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  1. School of Dental Medicine, Department of Periodontics, University of Pennsylvania, Philadelphia, PA, USA

    Sinem Esra Sahingur

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Rakian, A., Rakian, R., Alshehri, N., Van Dyke, T.E. (2020). Resolvins in Periodontal Tissue Homeostasis (Emerging Therapies). In: Sahingur, S. (eds) Emerging Therapies in Periodontics. Springer, Cham. https://doi.org/10.1007/978-3-030-42990-4_3

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  • DOI: https://doi.org/10.1007/978-3-030-42990-4_3

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