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Bacterial Peptides Targeting Periodontal Pathogens in Communities

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Emerging Therapies in Periodontics

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Abstract

Colonization and virulence of Porphyromonas gingivalis are enhanced through interactions with synergistic organisms in plaque biofilm communities. Conversely, some oral community inhabitants are antagonistic toward P. gingivalis. As many of the effectors of synergism and antagonism are proteinaceous, peptide-based inhibition of synergism or stimulation of antagonism are attractive strategies to reduce P. gingivalis pathogenicity and to prevent and treat periodontitis. Recent years have witnessed the development of peptides, and their functional mimics, designed to impede the assembly of adhesins, block the attachment of P. gingivalis to streptococcal substrata, or suppress the transcription and production of virulence factors. Coupled with advances in nanoparticle delivery systems, these approaches show promise for preventing the transition of the plaque biofilm from a commensal to a pathogenic entity.

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Authors and Affiliations

  1. Department of Oral Biology, Meharry Medical College, Nashville, TN, USA

    Hua Xie

  2. Department of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, KY, USA

    Richard J. Lamont

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  1. Hua Xie
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  1. School of Dental Medicine, Department of Periodontics, University of Pennsylvania, Philadelphia, PA, USA

    Sinem Esra Sahingur

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Xie, H., Lamont, R.J. (2020). Bacterial Peptides Targeting Periodontal Pathogens in Communities. In: Sahingur, S. (eds) Emerging Therapies in Periodontics. Springer, Cham. https://doi.org/10.1007/978-3-030-42990-4_11

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