Abstract
Distinguishing between right and left heart failure is often difficult. Fatigue, elevated neck veins, and lower extremity edema in the setting of clear lungs should prompt suspicion for primarily right heart failure (RHF); however, these signs and symptoms are neither sensitive nor specific for RHF. The diagnosis of RHF is typically made after left-sided pathologies have been excluded, and the underlying cause of a patient’s symptoms has been identified. Unfortunately, no generalizable therapies have been proven to augment right ventricular function, rather we are limited to a few targeted interventions for specific disease processes. Maintenance of euvolemia is typically the primary goal in the treatment of RHF. Chronic RHF can also be associated with cardiorenal syndrome, congestive hepatopathy, and gastric abnormalities. RHF portends a poor prognosis and is associated with increased mortality.
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References
Gan C, Lankhaar J, Marcus J, Westerhof N, Marques K, Bronzwaer J, et al. Impaired left ventricular filling due to right-to-left ventricular interaction in patients with pulmonary arterial hypertension. Am J Physiol Heart Circ Physiol. 2006;290(4):H1528–33. https://doi.org/10.1152/ajpheart.01031.2005.
Samsky M, Patel C, DeWald T, Smith A, Felker G, Rogers J, Hernandez A. Cardiohepatic interactions in heart failure: an overview and clinical implications. J Am Coll Cardiol. 2013;61(24):2397–405. https://doi.org/10.1016/j.jacc.2013.03.042.
Konstam M, Kiernan M, Bernstein D, Bozkurt B, Jacob M, Kapur N, American Heart Association Council on Clinical Cardiology, Council on Cardiovascular Disease in the Young, and Council on Cardiovascular Surgery and Anesthesia, et al. Evaluation and management of right-sided heart failure: a scientific statement from the American Heart Association. Circulation. 2018;137(20):e578–622. https://doi.org/10.1161/CIR.0000000000000560.
Mullens W, Abrahams Z. Importance of venous congestion for worsening of renal function in advanced decompensated heart failure. J Am Coll Cardiol. 2009;53:589–96. https://doi.org/10.1016/j.jacc.2008.05.068.
Wilfried Mullens ZA. Elevated intra-abdominal pressure in acute decompensated heart failure. J Am Coll Cardiol. 2008;51(3):300–6. https://doi.org/10.1016/j.jacc.2007.09.043.
Dixon DL, Mayne GC. Chronic elevation of pulmonary microvascular pressure in chronic heart failure reduces bi-directional pulmonary fluid flux. Eur J Heart Fail. 2013;15(4):368–75. https://doi.org/10.1093/eurjhf/hfs201.
Townsley MI, Fu Z, Mathieu-Costello O. Pulmonary microvascular permeability. Responses to high vascular pressure after induction of pacing-induced heart failure in dogs. Circ Res. 1995;77(2):317–25. https://doi.org/10.1161/01.RES.77.2.317.
Huang W, Kingsbury M, Turner M, Donnelly J, Sheridan DJ, Flores NA. Capillary filtration is reduced in lungs adapted to chronic heart failure: morphological and haemodynamic correlates. Cardiovasc Res. 2001;49(1):207–17. https://doi.org/10.1016/S0008-6363(00)00223-6.
Rizkallah J, Jack M, Saeed M, Shafer L, Vo M, Tam J. Non-invasive bedside assessment of central venous pressure: scanning into the future. PLoS One. 2014;9(10):e109215. https://doi.org/10.1371/journal.pone.0109215.
Dunn G, Hayes P, Breen K, Schenker S. The liver in congestive heart failure: a review. Am J Med Sci. 1973;265(3):174–89. https://doi.org/10.1097/00000441-197303000-00001.
Myers RP, Cerini R, Sayegh R, Moreau R, Degott C, Lebrec D, Lee SS. Cardiac hepatopathy: clinical, hemodynamic, and histologic characteristics and correlations. Hepatology. 2003;37(2):393–400. https://doi.org/10.1053/jhep.2003.50062.
Møller S, Bernardi M. Interactions of the heart and the liver. Eur Heart J. 2013;34(36):2804–11. https://doi.org/10.1093/eurheartj/eht246.
Anton Vonk Noordegraaf BE. The relationship between the right ventricle and its load in pulmonary hypertension. J Am Coll Cardiol. 2017;69(2):236–43. https://doi.org/10.1016/j.jacc.2016.10.047.
Ryan J, Huston J, Kutty S, Hatton N, Bowman L, Tian L, et al. Right ventricular adaptation and failure in pulmonary arterial hypertension. Can J Cardiol. 2015;31(4):391–406. https://doi.org/10.1016/j.cjca.2015.01.023.
Ronco C, Haapio M, House A, Anavekar N, Bellomo R. Cardiorenal syndrome. J Am Coll Cardiol. 2008;52(19):1527–39. https://doi.org/10.1016/j.jacc.2008.07.051.
Groenveld H, Januzzi J, Damman K, van Wijngaarden J, Hillege H, van Veldhuisen D, van der Meer P. Anemia and mortality in heart failure patients a systematic review and meta-analysis. J Am Coll Cardiol. 2008;52(10):818–27. https://doi.org/10.1016/j.jacc.2008.04.061.
Alvarez A, Mukherjee D. Liver abnormalities in cardiac diseases and heart failure. Int J Angiol. 2011;20(3):135–42. https://doi.org/10.1055/s-0031-1284434.
Poelzl G, Ess M, Mussner-Seeber C, Pachinger O, Frick M, Ulmer H. Liver dysfunction in chronic heart failure: prevalence, characteristics and prognostic significance. Eur J Clin Investig. 2012;42(2):153–63. https://doi.org/10.1111/j.1365-2362.2011.02573.x.
Hiew C, Collins N. Successful surgical treatment of protein-losing enteropathy complicating rheumatic tricuspid regurgitation. Heart Lung Circ. 2008;17(1):73–5. https://doi.org/10.1016/j.hlc.2006.11.004.
Hasse M, Müller C, Damman K, Murray P, Kellum J, Ronco C, McCullough P. Pathogenesis of cardiorenal syndrome type 1 in acute decompensated heart failure: workgroup statements from the eleventh consensus conference of the Acute Dialysis Quality Initiative (ADQI). Contrib Nephrol. 2013;182:99–116. https://doi.org/10.1159/000349969.
Harjola V, et al. Contemporary management of acute right ventricular failure: a statement from the Heart Failure Association and the Working Group on Pulmonary Circulation and Right Ventricular Function of the European Society of Cardiology. Eur J Heart Fail. 2016;18(3):226–41. https://doi.org/10.1002/ejhf.478.
Troughton R, Prior D, Pereira J, Martin M, Fogarty A, Morehead A, et al. Plasma B-type natriuretic peptide levels in systolic heart failure: importance of left ventricular diastolic function and right ventricular systolic function. J Am Coll Cardiol. 2004;43(3):416–22. https://doi.org/10.1016/j.jacc.2003.08.046.
Mariano-Goulart D, Eberlé M, Boudousg V, Hejazi-Moughari A, Piot C, Caderas de Kerleau C, et al. Major increase in brain natriuretic peptide indicates right ventricular systolic dysfunction in patients with heart failure. Eur J Heart Fail. 2003;5(4):481–8. https://doi.org/10.1016/s1388-9842(03)00041-2.
Benza R, Gomberg-Maitland M, Miller D, Frost A, Frantz R, Foreman A, et al. The REVEAL Registry risk score calculator in patients newly diagnosed with pulmonary arterial hypertension. Chest. 2012;141(2):354–62. https://doi.org/10.1378/chest.11-0676.
Yancy C, et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2013;62(16):e147–239. https://doi.org/10.1016/j.jacc.2013.05.019.
Forfia PR, Fisher MR, Mathai SC, Housten-Harris T, Hemnes AR, Borlaug BA, et al. Tricuspid annular displacement predicts survival in pulmonary hypertension. Am J Respir Crit Care Med. 2006;174(9):1034–41. https://doi.org/10.1164/rccm.200604-547OC.
Galea N, Carbone I. Right ventricular cardiovascular magnetic resonance imaging: normal anatomy and spectrum of pathological findings. Insights Imaging. 2013;4(2):213–23. https://doi.org/10.1007/s13244-013-0222-3.
Ameri P, Bertero E, Meliota G, Cheli M, Canepa M, Brunelli C, Balbi M. Neurohormonal activation and pharmacological inhibition in pulmonary arterial hypertension and related right ventricular failure. Heart Fail Rev. 2016;21(5):539–47. https://doi.org/10.1007/s10741-016-9566-3.
Vaillancourt M, Chia P, Sarji S, Nguyen J, Hoffman N, Ruffenach G, et al. Autonomic nervous system involvement in pulmonary arterial hypertension. Respir Res. 2017;18(1):201. https://doi.org/10.1186/s12931-017-0679-6.
Alajaji W, Baydoun A, Al-Kindi S, Henry L, Hanna M, Oliveira G. Digoxin therapy for cor pulmonale: a systematic review. Int J Cardiol. 2016;223:320–4. https://doi.org/10.1016/j.ijcard.2016.08.018.
Nishimura RA, Otto CM, et al. 2014 AHA/ACC guideline for the management of patients with valvular heart disease. J Am Coll Cardiol. 2014;63(22):57–185. Retrieved 2019.
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Blomberg, C.P., Syed, W.A., Tsao, L. (2020). New Onset Heart Failure: Which Side Is It, Right or Left?. In: Tsao, L., Afari, M. (eds) Clinical Cases in Right Heart Failure. Clinical Cases in Cardiology. Springer, Cham. https://doi.org/10.1007/978-3-030-38662-7_2
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DOI: https://doi.org/10.1007/978-3-030-38662-7_2
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