Abstract
The knowledge of molecular language of symbiotic (probiotic) microorganisms allows for a more intensive and targeted development of the next generation of probiotics and functional foods. In our opinion, the development of a traditional probiotic concept includes the creation of therapeutics, dietary supplements and functional foods that can be denoted by the common term of “metabiotics” (Shenderov 2007; Shenderov 2009; Shenderov 2011a; Shenderov 2011b; Shenderov 2013; Shenderov et al. 2018). We suggest to understand by the term all microecological products designed to preserve and restore the content and functions of symbiotic microbiota in humans, animals and plants and based on water soluble components of cells, metabolites and signaling molecules secreted or released at the time of microbial cell destruction in known or potential probiotic strains of microorganisms, as well as synthetic (and/or semisynthetic) metabiotics which will be artificially constructed as analogues or improved copies of natural biologically active compounds formed by symbiotic microorganisms. Metabiotics have a known chemical structure and their application allows to optimize organism-specific epigenetic, physiological functions, regulatory, metabolic and/or behavioral reactions related to the activity of host indigenous microbiota. This new group of microecological products should be equal to or surpass the first-generation probiotics in their therapeutic and prophylactic efficiency, while being safer than traditional probiotics.
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Bibliography
Aguilar-Toaláa JE, Garcia-Varela R, Garcia HS, Mata-Harod V, González-Córdovaa AF et al. Postbiotics: An evolving term within the functional foods field. Trends in Food Science & Technology. 2018;75:105–114. doi:https://doi.org/10.1016/j.tifs.2018.03.009.
Almada CN, Almada CN, Martinez RCR, Sant'Ana AS. Paraprobiotics: Evidences on their ability to modify biological responses, inactivation methods and perspectives on their application in foods. Trends in Food Science & Technology. 2016;58:96–114. doi:https://doi.org/10.1016/j.tifs.2016.09.011.
Ardatskaya MD Probiotics, prebiotics and metabiotics in the correction of microecological bowel disorders. Medical Council. 2015;3:94–99 (in Russian).
Caselli M, Vaira G, Calo G, Papini F, Holton J, Vaira D. Structural bacterial molecules as potential candidates for an evolution of the classical concept of probiotics. Adv Nutr. 2011;2:372–376. doi:https://doi.org/10.3945/an.111.000604.
Engevik MA, Versalovic J. Biochemical feature of beneficial microbes: foundation for therapeutic microbiology. Microbial Spectr. 2017;5(5). doi:https://doi.org/10.1128/microbiolspec.BAD-0012-2016.
Holmes E, Li JV, Athanasiou T, Ashrafian H, Nicholson JK. Understanding the role of gut microbiome-host metabolic signal disruption in health and disease. Trends Microbiol. 2011;19:349–359. doi:https://doi.org/10.1016/j.tim.2011.05.006.
Indriyani A, Juffrie M, Satyati A. Effect of live verses heat killed probiotics on acute diarrhea in young children. Paediatrica Indonesiana. 2012;52:249–254.
Lebeer S, Vanderleyden J, De Keersmaeker SCJ. Genes and molecules of lactobacilli supporting probiotic action. Microbiol Mol Biol Rev. 2008;72(4):728–764. doi:https://doi.org/10.1128/MMBR.00017-08.
Lebeer S, Vanderleyden J, De Keersmaeker SCJ. Host interactions of probiotic bacterial surface molecules: cоmparison with commensals and pathogens. Natl Rev Microbiol. 2010; 8(3):171–184. doi:https://doi.org/10.1038/nrmicro2297.
Maguire M, Maguire G. Gut dysbiosis, leaky gut, and intestinal epithelial proliferation in neurological disorders: towards the development of a new therapeutic using amino acids, prebiotics, probiotics, and postbiotics. Rev Neurosci. 2019;30(2):179–201. doi:https://doi.org/10.1515/revneuro-2018-0024.
Neish AS. Microbes in gastrointestinal health and disease. Gastroenterology. 2009;136(1):65–80. doi:https://doi.org/10.1053/j.gastro.2008.10.080.
Ploskireva AA. Metabolic therapy of microbiocenosis disorders in different biotopes of the human body. Attending Physician. 2016;7(2):632–642 (in Russian).
Shaikh AM, Sreeja V. Metabiotics and their Health Benefits. Intl. J. Food. Ferment. 2017;6(1):11–23. doi:https://doi.org/10.5958/2321-712X.2017.00002.3.
Sharma M, Shukla G. Metabiotics: One Step ahead of Probiotics; an Insight into Mechanisms Involved in Anticancerous Effect in Colorectal Cancer. Front. Microbiol. 2016;7:1940. doi:https://doi.org/10.3389/fmicb.2016.01940.
Shenderov BA, Ivanova YaV, Sorokina IM. Complex food product enrichment. PATENT RF 2397246. 2010 (in Russian).
Shenderov BA, Manvelova MA, Stepanchuk JuB, Skiba NE. Probiotic and Functional Nutrition. Antibiotics and Chemotherapy. 1997;42(7):30–34 (in Russian).
Shenderov BA. Metabiotics — novel prophylactic technology of diseases associated with microecological imbalance of human being. Journal of Restorative Medicine & Rehabilitation. 2017;4:40–49 (in Russian).
Shenderov BA. Modern Condition and Prospective Host Microecology Investigations. Microb Ecol Heath Dis. 2007;19(3):145–149. doi:https://doi.org/10.1080/08910600701520933.
Shenderov BA. Molecular language of probiotic microorganisms. Food ingredients: Raw materials & additives. 2009;1:47–48 (in Russian).
Shenderov BA. Probiotic (symbiotic) bacterial languages. Anaerobe. 2011a;17(6):490–495. doi:https://doi.org/10.1016/j.anaerobe.2011.05.009.
Singh A, Vishwakarma V, Singhal B. Metabiotics: The Functional Metabolic Signatures of Probiotics: Current State-of-Art and Future Research Priorities — Metabiotics: Probiotics Effector Molecules. Advan Biosci Biotechnol. 2018;9(4):147–189. doi:https://doi.org/10.4236/abb.2018.94012.
Sobol CV. A new class of Pharmabiotics with Unique Properties. Chapter 4. In: Grumezescu AM, Holban AM, editors. Handbook of Food Bioengineering. Vol. 3. Soft Chemistry and Food Fermentation. London: Elsevier Inc.; 2017. p. 79–108. doi:https://doi.org/10.1016/B978-0-12-811412-4.00004-7.
Sonnenburg JL, Fischbach MA. Community health care: therapeutic opportunities in the human microbiome. Sci Transl Med. 2011;3(78):78ps12. doi:https://doi.org/10.1126/scitranslmed.3001626.
Tsilingiri K, Rescigno M. Postbiotics: what else? Benefic Microb. 2012;4(1):101–107. doi:https://doi.org/10.3920/BM2012.0046.
Vakhitov TYa, Petrov LN, Bondarenko VM. The concept of a probiotic drug containing original microbial metabolites. Zh Mikrobiol (Moscow). 2005; 5:108–114 (in Russian).
Vakhitov TYa, Sitkin SI. The concept of superorganism in biology and medicine. Experimental & clinical gastroenterology. 2014;107(7):72–85 (in Russian).
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Shenderov, B.A., Sinitsa, A.V., Zakharchenko, M.M., Lang, C. (2020). Metabiotics: New Stage of the Probiotic Concept Development. In: METABIOTICS. Springer, Cham. https://doi.org/10.1007/978-3-030-34167-1_10
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DOI: https://doi.org/10.1007/978-3-030-34167-1_10
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