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Curcumin and Its Nanoformulations as Therapeutic for Alzheimer’s Disease

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Nanobiotechnology in Neurodegenerative Diseases

Abstract

Since decades curcumin has been known for its pleiotropic nature and for its biological effects which broadly include its antioxidant, anti-inflammatory, and anticancer potential. Plethora of published articles are a proof of pluripotent effect of curcumin against various neurodegenerative disorders including Alzheimer’s disease. Mechanistically, naive curcumin inhibits the formation of amyloid-β plaques, attenuates the hyperphosphorylation of tau and enhances its clearance, binds copper, lowers the cholesterol level, modifies microglial activity, inhibits acetyl cholinesterase, mediates the insulin signaling pathway, and is reported to be a very effective antioxidant. However, its usefulness as a therapeutic agent is hindered by its compromised bioavailability due to low aqueous solubility (11 ng/mL) and low permeability (log 3.28). Nano-delivery systems like liposomes, polymeric nanoparticles, micelles, conjugates, peptide carriers, cyclodextrins, solid dispersions, lipidic nanoparticles, and emulsions have been extensively explored for enhancing the overall bioavailability of curcumin. This book chapter has been written to describe scope of using curcumin and its nanoformulation(s) as therapeutics for Alzheimer’s disease. Ongoing clinical trials on curcumin are also covered. Various curcumin-based products currently available in the market or those in the pipeline are also discussed.

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Authors and Affiliations

  1. Department of Pharmaceutics, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India

    Vandita Kakkar, Parina Kumari, Suneera Adlakha & Indu Pal Kaur

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  1. Vandita Kakkar
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  3. Suneera Adlakha
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  4. Indu Pal Kaur
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Editors and Affiliations

  1. Nanobiotechnology Laboratory, Department of Biotechnology, SGB Amravati University, Amravati, Maharashtra, India, Department of Chemistry, Federal University of Piauí, Teresina, Piauí, Brazil

    Mahendra Rai

  2. Nanobiotechnology Laboratory, Department of Biotechnology, SGB Amravati University, Amravati, Maharashtra, India

    Alka Yadav

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Kakkar, V., Kumari, P., Adlakha, S., Kaur, I.P. (2019). Curcumin and Its Nanoformulations as Therapeutic for Alzheimer’s Disease. In: Rai, M., Yadav, A. (eds) Nanobiotechnology in Neurodegenerative Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-30930-5_14

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