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Biosynthesis and Degradation of Trehalose and Its Potential to Control Plant Growth, Development, and (A)biotic Stress Tolerance

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Osmoprotectant-Mediated Abiotic Stress Tolerance in Plants

Abstract

Trehalose is a nonreducing disaccharide that consists of two glucose monomers bound by an α,α-1,1-glucoside bond. Trehalose is present in a wide range of organisms such as bacteria, fungi, invertebrates, and plants. It has been demonstrated that trehalose stabilizes proteins and lipid membranes under various stress conditions, including heat stress, carbon starvation, osmotic or oxidative stress, etc. In most plants, trehalose levels are negligible, although there are many genes linked to trehalose biosynthesis. For instance, in Arabidopsis thaliana, there are 11 orthologues of the microbial trehalose-6-phosphate (T6P) synthase (TPS) family, divided in 2 classes, and there are 10 T6P phosphatases (TPPs). TPS converts UDP-glucose and glucose-6-phosphate into T6P with the help of TPS enzymes, and this T6P is hydrolyzed by TPPs to produce trehalose. In general, there is much less and often only one (as in A. thaliana) enzyme trehalase (TRE) that hydrolyzes trehalose into two glucose monomers. It has been shown that trehalose metabolism is critical for normal plant growth and development. Trehalose feeding causes growth arrest as stunted root growth and undeveloped primary leaves of seedlings. Modification of T6P levels by expression of either microbial TPS or TPP enzymes also results in aberrant growth phenotypes, which indicates that the level of T6P is very important for correct plant development. T6P levels also provide plants with information regarding the sugar status of the plants. Overexpression of both TPS and TPP or overexpression of active plant TPS enzymes results in small increases in trehalose levels and in an increased stress tolerance. However, the latter phenotype cannot be explained by the stress-protecting characteristics of trehalose as the concentrations are too low. Therefore, the hypothesis is that small changes in trehalose and/or T6P levels affect many plant characteristics, including growth, development, and stress tolerance. All these aspects are discussed in this chapter with a focus on what is known in A. thaliana but also including the recent findings in crop plants.

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Authors and Affiliations

  1. VIB-KU Leuven Center for Microbiology, Heverlee, Belgium

    Le Cong Huyen Bao Tran Phan & Patrick Van Dijck

  2. Laboratory of Molecular Cell Biology, KU Leuven, Leuven, Belgium

    Le Cong Huyen Bao Tran Phan & Patrick Van Dijck

  3. Department of Biology, College of Natural Sciences, Can Tho University, Can Tho, Vietnam

    Le Cong Huyen Bao Tran Phan

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  1. Le Cong Huyen Bao Tran Phan
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  2. Patrick Van Dijck
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Correspondence to Patrick Van Dijck .

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Editors and Affiliations

  1. Department of Genetics and Plant Breeding, Bangladesh Agricultural University, Mymensingh, Bangladesh

    Mohammad Anwar Hossain

  2. Department of Biotechnology, Modern College, Pune, Maharashtra, India

    Vinay Kumar

  3. Department of Botany, University of Otago, Dunedin, Otago, New Zealand

    David J. Burritt

  4. Laboratory of Plant Stress Responses, Kagawa University, Kagawa, Kagawa, Japan

    Masayuki Fujita

  5. Department of Agricultural Sciences, University of Helsinki, Helsinki, Finland

    Pirjo S. A. Mäkelä

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Phan, L.C.H.B.T., Van Dijck, P. (2019). Biosynthesis and Degradation of Trehalose and Its Potential to Control Plant Growth, Development, and (A)biotic Stress Tolerance. In: Hossain, M., Kumar, V., Burritt, D., Fujita, M., Mäkelä, P. (eds) Osmoprotectant-Mediated Abiotic Stress Tolerance in Plants. Springer, Cham. https://doi.org/10.1007/978-3-030-27423-8_8

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