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Insufficient/Inadequate

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The International Academy of Cytology Yokohama System for Reporting Breast Fine Needle Aspiration Biopsy Cytopathology

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Abstract

This chapter defines a breast smear which is insufficient for diagnosis and is based on a cytological assessment of the material on the slide. The factors affecting the inadequate rate include the inherent qualities of the lesion, the expertise of the operator and the quality of the smear. The category does not require a specific number of epithelial cells to be present, but does require clinical-radiological correlation with the cytology (the triple test).

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References

  1. National Cancer Institute sponsored conference. Bethesda, MD, 1996. Special communication: The uniform approach to breast fine-needle aspiration biopsy. Diagn Cytopathol. 1997;16:2295–311.

    Google Scholar 

  2. Layfield LJ, Mooney EE, Glasgow B, Hirschowitz S, Coogan A. What constitutes an adequate smear in fine-needle aspiration cytology of the breast? Cancer. 1997;81:16–21.

    Article  CAS  Google Scholar 

  3. Pisano ED, Fajardo LL, Tsimikas J, et al.  Rate of insufficient samples for fine-needle aspiration for nonpalpable breast lesions in a multicenter clinical trial: the Radiologic Diagnostic Oncology Group 5 Study. The RDOG5 investigators. Cancer. 1998;82:679–88.

    Article  CAS  Google Scholar 

  4. Ducatman BS, Wang HH. Breast. In: Cibas E, Ducataman B, editors. Ch 9 in Cytology: Principles and Clinical Correlates. 4th ed. Philadelphia: Elsevier/Saunders; 2014.

    Google Scholar 

  5. Rubenchik I, Sneige N, Edeiken B, Samuels B, Fornage B. In search of specimen adequacy in fine-needle aspirates of nonpalpable breast lesions. Am J Clin Pathol. 1997;108:13–8.

    Article  CAS  Google Scholar 

  6. Boerner S, Sneige N. Specimen adequacy and false-negative diagnosis rate in fine-needle aspirates of palpable breast masses. Cancer Cytopathol. 1998;84:344–8.

    Article  CAS  Google Scholar 

  7. Mendoza P, Lacambra M, Tan PH, Tse GM. Fine needle aspiration cytology of the breast: the nonmalignant categories. Pathology Res Int. 2011;2011:547580.

    Article  Google Scholar 

  8. Yu Y-H, Wei W, Liu J-L. Diagnostic value of fine needle aspiration biopsy for breast mass: a systematic review and meta-analysis. BMC Cancer. 2012;12:41–60.

    Article  Google Scholar 

  9. Pisano ED, et al. Fine needle aspiration biopsy of nonpalpable breast lesions in a multicenter clinical trial: results from the radiologic diagnostic oncology group. Radiology. 2001;219(3):785–92.

    Article  CAS  Google Scholar 

  10. Hoda R, Brachtel E. IAC Yokohama System for reporting breast FNAB cytology: a review of predictive values and risks of malignancy. Acta Cytol. 2019;63:292–301.

    Google Scholar 

  11. Montezuma D, Malheiros D, Schmitt F. Breast FNAB cytology using the newly proposed IAC Yokohama system for reporting breast cytopathology: the experience of a single institution. Acta Cytol. 2019;63:274–9.

    Google Scholar 

  12. Wong S, Rickard M, Earls P, Arnold L, Bako B, Field AS. The IAC Yokohama System for reporting breast FNAB cytology: a single institutional retrospective study of the application of the System and the impact of ROSE. Acta Cytol. 2019;63:280–91.

    Google Scholar 

  13. Eckert R, et al. Number, size and composition of cell clusters as related to breast FNA adequacy. Diagn Cytopathol. 1999;21:105–11.

    Article  CAS  Google Scholar 

  14. Howell LP, Gandour-Edwards R, Folkins K, et al. Adequacy evaluation of fine-needle aspiration biopsy in the breast health clinic setting. Cancer Cytopathol. 2004;102:295–301.

    Article  Google Scholar 

  15. Abele JS, Wagner LT, Miller TR. Fine-needle aspiration of the breast: cell counts as an illusion of adequacy. A clinical cytopathologist’s point of view. Cancer Cytopathol. 1998;84:319–23.

    Article  CAS  Google Scholar 

  16. Field AS. Chapter 5 Breast. In: Field AS, Zarka MR, editors. Practical Cytopathology: Pattern Recognition Diagnostic Approach. Saint Louis: Elsevier; 2016.

    Google Scholar 

  17. Patel JJ, Gartell PC, Smallwood JA, Herbert A, Royle G, Buchanan R, Taylor I. Fine needle aspiration cytology of breast masses: an evaluation of its accuracy and reasons for diagnostic failure. Ann R Coll Surg Engl. 1987;69:156–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  18. Feichter GE, et al. Breast cytology: statistical analysis and cytohistologic correlation. Acta Cytol. 1997;41:327–32.

    Article  CAS  Google Scholar 

  19. Park IA, Ham EK. Fine needle aspiration cytology of palpable breast lesions. Histologic subtype in false negative cases. Acta Cytol. 1997;41:1131–8.

    Article  CAS  Google Scholar 

  20. Lamb J, Anderson TJ. Influence of cancer histology on the success of fine needle aspiration of the breast. J Clin Pathol. 1989;42:733–5.

    Article  CAS  Google Scholar 

  21. Yamaguchi R, Tsuchiya SΙ, Koshikawa T, et al. Diagnostic accuracy of fine-needle aspiration cytology of the breast in Japan: report from the Working Group on the Accuracy of Breast Fine-Needle Aspiration Cytology of the Japanese Society of Clinical Cytology. Oncol Rep. 2012;28:1606–12.

    Article  Google Scholar 

  22. Hammond S, Keyhani-Rofagha S, O’Toole RV. Statistical analysis of fine needle aspiration cytology of the breast. A review of 678 cases plus 4,265 cases from the literature. Acta Cytol. 1987;37:276–80.

    Google Scholar 

  23. Lieske B, Ravichandran D, Wright D. Role of fine-needle aspiration cytology and core biopsy in the preoperative diagnosis of screen-detected breast carcinoma. Br J Cancer. 2006;95:62–6.

    Article  CAS  Google Scholar 

  24. Barrows GH, Anderson TJ, Lamb JL, Dixon JM. Fine-needle aspiration of breast cancer. Relationship of clinical factors to cytology results in 689 primary malignancies. Cancer. 1986;58:1493–8.

    Article  CAS  Google Scholar 

  25. Lee KR, Foster RS, Papillo JL. Fine needle aspiration of the breast. Importance of the aspirator. Acta Cytol. 1987;31:281–4.

    CAS  PubMed  Google Scholar 

  26. Snead DRJ, Vryenhoef P, Pinder SE, Evans A, Wilson ARM, Blamey RW, Elston CW, Ellis IO. Routine audit of breast fine needle aspiration (FNA) cytology specimens and aspirator inadequate rates. Cytopathology. 1997;8:236–47.

    Article  CAS  Google Scholar 

  27. Ljung BM, Drejet A, Chiampi N, et al. Diagnostic accuracy of FNAB is determined by physician training in sampling technique. Cancer Cytopathol. 2001;93:263–8.

    Article  CAS  Google Scholar 

  28. Palombini L, Fulciniti F, Vetrani A, et al. Fine-needle aspiration biopsies of breast masses. A critical analysis of 1956 cases in 8 years (1976-1984). Cancer. 1988;61:2273–7.

    Article  CAS  Google Scholar 

  29. Vural G, Hagmar B, Lilleng R. A one-year audit of fine needle aspiration cytology of breast lesions. Factors affecting adequacy and a review of delayed carcinoma diagnoses. Acta Cytol. 1995;39:1233–6.

    CAS  PubMed  Google Scholar 

  30. Gomez-Macias GS, Garza-Guajardo R, Segura-Luna J, Barboza-Quintana O. Inadequate FNAB Samples: Pathologists Versus Other Specialists. Cytojournal. 2009;6:9–14.

    Google Scholar 

  31. Patel JJ, Gartell PC, Guyer PB, et al. Use of ultrasound localization to improve results of fine needle aspiration cytology of breast masses. J R Soc Med. 1988;81:10–2.

    Article  CAS  Google Scholar 

  32. Pennes DR, Naylor B, Rebner M. Fine needle aspiration biopsy of the breast. Influence of the number of passes and the sample size on the diagnostic yield. Acta Cytol. 1990;34:673–6.

    CAS  PubMed  Google Scholar 

  33. Bukhari MH, Arshad M, Jamal S, et al. Use of fine needle aspiration cytology in the evaluation of breast lumps. Patholog Res Int. 2011;2011:689521.

    Google Scholar 

  34. Kline TS, Joshi LP, Neal HS. Fine-needle aspiration of the breast: diagnoses and pitfalls. A review of 3545 cases. Cancer. 1979;44:1458–64.

    Article  CAS  Google Scholar 

  35. Brown LA, Coghill SB. Fine needle aspiration cytology of the breast: factors affecting sensitivity. Cytopathology. 1991;2:67–74.

    Article  CAS  Google Scholar 

  36. Ciatto S, Cariaggi P, Bulgaresi P, Confortini M, Bonardi R. Fine needle aspiration cytology of the breast: review of 9533 consecutive cases. Breast. 1993;2:87–90.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Flinders Medical Centre, Flinders University of South Australia and Clinpath Laboratories, Adelaide, Australia

    Wendy A. Raymond

  2. University of NSW and University of Notre Dame Medical Schools, St Vincent’s Hospital, Sydney, Australia

    Andrew S. Field

  3. Department of Histopathology, Nottingham University Hospitals, Nottingham, UK

    Andrew H. S. Lee

  4. Institute of Molecular Pathology and Immunology of Porto University (IPATIMUP), Medical Faculty of Porto University, Porto, Portugal

    Fernando Schmitt

Authors
  1. Wendy A. Raymond
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  2. Andrew S. Field
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  3. Andrew H. S. Lee
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  4. Fernando Schmitt
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Corresponding author

Correspondence to Andrew S. Field .

Editor information

Editors and Affiliations

  1. University of NSW and University of Notre Dame Medical Schools, St Vincent’s Hospital, Sydney, Australia

    Andrew S. Field

  2. Flinders Medical Centre, Flinders University of South Australia and Clinpath Laboratories, Adelaide, Australia

    Wendy A. Raymond

  3. Institute of Molecular Pathology and Immunology of Porto University (IPATIMUP), Medical Faculty of Porto University, Porto, Portugal

    Fernando Schmitt

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Raymond, W.A., Field, A.S., Lee, A.H.S., Schmitt, F. (2020). Insufficient/Inadequate. In: Field, A.S., Raymond, W.A., Schmitt, F. (eds) The International Academy of Cytology Yokohama System for Reporting Breast Fine Needle Aspiration Biopsy Cytopathology. Springer, Cham. https://doi.org/10.1007/978-3-030-26883-1_2

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  • DOI: https://doi.org/10.1007/978-3-030-26883-1_2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-26882-4

  • Online ISBN: 978-3-030-26883-1

  • eBook Packages: MedicineMedicine (R0)

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