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Clinical Significance of Enzymes in Disease and Diagnosis

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Biocatalysis

Abstract

Over the years, enzymes have emerged as critical regulators of human diseases. In addition, as biomarkers, some enzymes often present consequential cue about the disease state due to their corresponding altered pattern in tissues and serum. A vast embodiment of data from experimental research in model organisms and humans has ensured the clinical utilization of specific enzymes as an evidence-based strategy in disease prevention and diagnosis. These have been incorporated in the diagnostic premises as biomarkers, which are quantifiable laboratory measure of a disease specific biologically relevant molecule that can act as an indicator of a disease burden. This chapter provides a brief review of the current paradigm on harnessing the clinical utility of enzymes with potential impact in the diagnosis of cancer disease, myocardial disorders and gastrointestinal tract related impairments in humans.

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References

  • Abbas M, Abbas Z (2017) Serum cholinesterase: a predictive biomarker of hepatic reserves in chronic hepatitis D. World J Hepatol 9(22):967

    PubMed  PubMed Central  Google Scholar 

  • Alegre MM, Weyant MJ, Bennett DT et al (2014) Serum detection of thymidine kinase 1 as a means of early detection of lung cancer. Anticancer Res 34:2145–2151

    PubMed  Google Scholar 

  • Aragon G, Younossi Z (2010) Evaluation of asymptomatic elevation of liver enzymes. Cleve Clin J Med 77(3):195–204

    PubMed  Google Scholar 

  • Aufderklamm S, Todenhöfer T, Gakis G, Kruck S, Hennenlotter J, Stenzl A, Schwentner C (2012) Thymidine kinase and cancer monitoring. Cancer Lett 316(1):6–10

    CAS  PubMed  Google Scholar 

  • Bäumer AT, Flesch M, Wang X, Shen Q, Feuerstein GZ, Böhm M (2000) Antioxidative enzymes in human hearts with idiopathic dilated cardiomyopathy. J Mol Cell Cardiol 32(1):121–130

    PubMed  Google Scholar 

  • Bayes-Genis A, Conover CA, Overgaard MT, Bailey KR, Christiansen M, Holmes DR Jr, Virmani R, Oxvig C, Schwartz RS (2001) Pregnancy-associated plasma protein A as a marker of acute coronary syndromes. N Engl J Med 345(14):1022–1029

    CAS  PubMed  Google Scholar 

  • Berdowska I (2004) Cysteine proteases as disease markers. Clin Chim Acta 342:41–69

    CAS  PubMed  Google Scholar 

  • Bhattacharjee A, Richards WG, Staunton J et al (2001) Classification of human lungcarcinomas by mRNA expression profiling reveals distinct adenocarcinomasubclasses. Proc Natl Acad Sci U S A 98:13790–13795

    CAS  PubMed  PubMed Central  Google Scholar 

  • Bi MH, Han W, Liu JJ, Wang HY, Gao ZY, Tian WL (2016) Clinical significance of serum thymidine kinase 1 (TK1) expression in patients with non-small cell lung cancer. Int J Clin Exp Med 9:8536–8542

    CAS  Google Scholar 

  • Bloomberg DJ, Kimber WD, Burke MD (1975) Creatine kinase isoenzymes. Predictive value in the early diagnosis of acute myocardial infarction. Am J Med 59:464–469

    Google Scholar 

  • Borgono CA, Michael IP, Diamandis EP (2004) Human tissue kallikreins: physiologicroles and applications in cancer. Mol Cancer Res 2:257–280

    CAS  PubMed  Google Scholar 

  • BozbaÅŸ H, Yıldırır A, KaraçaÄŸlar E, Demir O, Ulus T, EroÄŸlu S, Aydınalp A, Özin B, MüderrisoÄŸlu H (2011) Increased serum gamma-glutamyltransferase activity in patients with metabolic syndrome. Turk Kardiyol Dern Ars 39(2):122–128

    PubMed  Google Scholar 

  • Cannavo A, Komici K, Bencivenga L, D’amico ML, Gambino G, Liccardo D, Ferrara N, Rengo G (2018) GRK2 as a therapeutic target for heart failure. Expert Opin Ther Targets 22(1):75–83

    CAS  PubMed  Google Scholar 

  • Cavusoglu E, Ruwende C, Eng C, Chopra V, Yanamadala S, Clark LT, Pinsky DJ, Marmur JD (2007) Usefulness of baseline plasma myeloperoxidase levels as an independent predictor of myocardial infarction at two years in patients presenting with acute coronary syndrome. Am J Cardiol 99:1364–1368

    CAS  PubMed  Google Scholar 

  • Chen ZH, Huang SQ, Wang Y et al (2011) Serological thymidine kinase 1 is a biomarker for early detection of tumours – a health screening study on 35,365 people, using a sensitive chemiluminescent dot blot assay. Sensors (Basel) 11:11064–11080

    CAS  Google Scholar 

  • Chen G, Chen Q, Zeng F et al (2017) The serum activity of thioredoxinreductases 1 (TrxR1) is correlated with the poor prognosis in EGFR wild-type and ALK negative non-small cell lung cancer. Oncotarget 8:115270–115279

    PubMed  PubMed Central  Google Scholar 

  • Chinnery PF (2014) Mitochondrial disorders overview. In: Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJ et al (eds) GeneReviews®. University of Washington Seattle, Seattle, WA

    Google Scholar 

  • Cízková A, Stránecký V, Mayr JA, Tesarová M, Havlícková V, Paul J et al (2008) TMEM70 mutations cause isolated ATP synthase deficiency and neonatal mitochondrial encephalocardiomyopathy. Nat Genet 40:1288–1290

    PubMed  Google Scholar 

  • Clarke SLN, Bowron A, Gonzalez IL, Groves SJ, Newbury-Ecob R, Clayton N et al (2013) Barth syndrome. Orphanet J Rare Dis 8:23

    PubMed  PubMed Central  Google Scholar 

  • Cohen JA, Kaplan MM (1979) The SGOT/SGPT ratio—an indicator of alcoholic liver disease. Dig Dis Sci 24(11):835–838

    CAS  PubMed  Google Scholar 

  • Crivellari D, Price KN, Hagen M et al (1995) Routine tests during follow-up of patients after primary treatment for operable breast cancer. International (Ludwig) Breast Cancer Study Group (IBCSG). Ann Oncol 6:769–776

    CAS  PubMed  Google Scholar 

  • Cuperus FJC, Drenth JPH, Tjwa ET (2017) Mistakes in liver function test abnormalities and how to avoid them. UEG Educ 17:1–5

    Google Scholar 

  • Dong C, Zhang L, Sun R et al (2016) Role of thioredoxinreductase 1 in dysplastic transformation of human breast epithelial cells triggered by chronic oxidative stress. Sci Rep 6:36860

    CAS  PubMed  PubMed Central  Google Scholar 

  • Dorn GW 2nd (2010) Adrenergic signaling polymorphisms and their impact on cardiovascular disease. Physiol Rev 90:1013–1062

    CAS  PubMed  Google Scholar 

  • Du X, Wang F, Hu Z, Wu J, Wang Z, Yan C, Zhang C, Tang J (2017) The diagnostic value of pepsin detection in saliva for gastro-esophageal reflux disease: a preliminary study from China. BMC Gastroenterol 17(1):107

    PubMed  PubMed Central  Google Scholar 

  • Dufour DR, Lott JA, Nolte FS, Gretch DR, Koff RS, Seeff LB (2000) Diagnosis and monitoring of hepatic injury. I. Performance characteristics of laboratory tests. Clin Chem 46(12):2027–2049

    CAS  PubMed  Google Scholar 

  • Edelman MJ, Watson D, Wang X et al (2008) Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy – Cancer and Leukemia Group B Trial 30203. J Clin Oncol 26:848–855

    CAS  PubMed  Google Scholar 

  • Ege MR, Guray U, Guray Y, Demirkan B, Kisacik H (2013) Serum γ-glutamyltransferase levels correlate with epicardial adipose tissue thickness in patients with coronary artery disease. Angiology 64(1):21–25

    CAS  PubMed  Google Scholar 

  • El-Hattab AW, Scaglia F (2015) Mitochondrial disorders. In: Lee B, Scaglia F (eds) Inborn errors of metabolism: from neonatal screening to metabolic pathways. Oxford University Press, New York, NY, pp 180–202

    Google Scholar 

  • El-Hattab AW, Scaglia F (2016) Mitochondrial Cardiomyopathies. Front Cardiovasc Med 3:25

    PubMed  PubMed Central  Google Scholar 

  • Esteban MTT (2006) Myocardial disease as a cause of sudden cardiac death syndrome in children and young adults: recognition and preventive strategies needed. Rev Esp Cardiol 59:197–199

    Google Scholar 

  • Everhart JE, Wright EC (2013) Association of γ-glutamyltransferase (GGT) activity with treatment and clinical outcomes in chronic hepatitis C (HCV). Hepatology 57(5):1725–1733

    CAS  PubMed  PubMed Central  Google Scholar 

  • Figler BD, Reuther AM, Dhar N et al (2007) Preoperative PSA is still predictive of cancer volume and grade in late PSA era. Urology 70:711–716

    PubMed  Google Scholar 

  • Fizazi K, Massard C, Smith M et al (2015) Bone-related parameters are the main prognostic factors for overall survival in men with bone metastases from castration-resistant prostate cancer. Eur Urol 68(1):42–50

    PubMed  Google Scholar 

  • Frangogiannis NG (2017) Fibroblasts and the extracellular matrix in right ventricular disease. Cardiovasc Res 113(12):1453–1464

    CAS  PubMed  PubMed Central  Google Scholar 

  • Gad HM, Elsisi AM, Ali AA (2015) Thioredoxinreductase as biomarker for differential diagnosis of prostate cancer. Az J Pharm Sci 52:140–149

    Google Scholar 

  • Gerhardt W, Katus H, Ravkilde J et al (1991) S-troponin T in suspected ischemic myocardial injury compared with mass and catalytic concentrations of S-creatine kinase isoenzyme MB. Clin Chem 37:1405–1411

    CAS  PubMed  Google Scholar 

  • Giannini EG, Testa R, Savarino V (2005) Liver enzyme alteration: a guide for clinicians. CMAJ 172(3):367–379

    PubMed  PubMed Central  Google Scholar 

  • Gilbert-Barness E (2004) Review: metabolic cardiomyopathy and conduction system defects in children. Ann Clin Lab Sci 34:15–34

    CAS  PubMed  Google Scholar 

  • Gocheva V, Johanna AJ (2007) Cysteine cathepsins and the cutting edge of cancerinvasion. Cell Cycle 6:60–64

    CAS  PubMed  Google Scholar 

  • Guan H, Sun Y, Zan Q, Xu M, Li Y, Zhou J, He E, Eriksson S, Wen W, Skog S (2009) Thymidine kinase 1 expression in atypical ductal hyperplasia significantly differs from usual ductal hyperplasia and ductal carcinoma in situ: a useful tool in tumor therapy management. Mol Med Rep 2:923–929

    CAS  PubMed  Google Scholar 

  • Haghighi A, Haack TB, Atiq M, Mottaghi H, Haghighi-Kakhki H, Bashir RA et al (2014) Sengers syndrome: six novel AGK mutations in seven new families and review of the phenotypic and mutational spectrum of 29 patients. Orphanet J Rare Dis 9:119

    PubMed  PubMed Central  Google Scholar 

  • Haris M, Singh A, Mohammed I, Ittyerah R, Nath K, Nanga RPR et al (2014) In vivo magnetic resonance imaging of tumor protease activity. Sci Rep 4:6081

    CAS  PubMed  PubMed Central  Google Scholar 

  • Harris RE, Casto BC, Harris ZM (2014) Cyclooxygenase-2 and the inflammogenesis of breast cancer. World J Clin Oncol 5:677–692

    PubMed  PubMed Central  Google Scholar 

  • Harrison SA, Kadakia S, Lang KA, Schenker S (2002) Nonalcoholic steatohepatitis: what we know in the new millennium. Am J Gastroenterol 97(11):2714

    CAS  PubMed  Google Scholar 

  • Hsu JY, Chang KY, Chen SH, Lee CT, Chang ST, Cheng HC, Chang WC, Chen BK (2015) Epidermal growth factor-induced cyclooxygenase-2 enhances head and neck squamous cell carcinoma metastasis through fibronectin up-regulation. Oncotarget 6:1723–1739

    PubMed  Google Scholar 

  • Hu Z, Yang Y, Zhao Y, Huang Y (2017) The prognostic value of cyclooxygenase-2 expression in patients with esophageal cancer: evidence from a meta-analysis. Onco Targets Ther 10:2893–2901

    PubMed  PubMed Central  Google Scholar 

  • Huang S, Lin J, Guo N, Zhang M, Yun X, Liu S, Zhou J, He E, Skog S (2011) Elevated serum thymidine kinase 1 predicts risk of pre/early cancerous progression. Asian Pac J Cancer Prev 12:497–505

    PubMed  Google Scholar 

  • Iacobuzio-Donahue CA, Ashfaq R, Maitra A et al (2003) Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies. Cancer Res 63:8614–8622

    CAS  PubMed  Google Scholar 

  • Ismail OZ, Bhayana V (2017) Lipase or amylase for the diagnosis of acute pancreatitis? Clin Biochem 50(18):1275–1280

    CAS  PubMed  Google Scholar 

  • Jansen PL (2004) Non-alcoholic steatohepatitis. Eur J Gastroenterol Hepatol 16(11):1079–1085

    PubMed  Google Scholar 

  • Jedeszko C, Sloane BF (2004) Cysteine cathepsins in human cancer. Biol Chem 385:1017–1027

    CAS  PubMed  Google Scholar 

  • Jefferies JL (2013) Barth syndrome. Am J Med Genet C Semin Med Genet 163C:198–205

    PubMed  Google Scholar 

  • Jemal A, Tiwari RC, Murray T, Ghafoor A et al (2004) Cancer statistics. CA Cancer J Clin 54:8–29

    PubMed  Google Scholar 

  • Ji F, Chen YL, Jin EY, Wang WL, Yang ZL, Li YM (2005) Relationship between matrixmetalloproteinase-2 mRNA expression and clinicopathological and urokinase type plasminogen activator system parameters and prognosis in human gastric cancer. World J Gastroenterol 11:3222–3226

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kang X, Dong C, Shen B et al (2017) Serum thioredoxinreductase 1 as a diagnostic marker for non-small cell lung cancer. J Clin Oncol 35(15_suppl):e23069–e23069

    Google Scholar 

  • Kaul N, Siveski-Iliskovic N, Thomas TP, Hill M, Khaper N, Singal PK (1995) Probucol improves antioxidant activity and modulates development of diabetic cardiomyopathy. Nutrition 11:551–554

    CAS  PubMed  Google Scholar 

  • Kennedy H, Haack TB, Hartill V et al (2016) Sudden cardiac death due to defficiency of the mitochondrial inorganic pyrophosphatase PPA2. Am J Hum Genet 99:674–682

    CAS  PubMed  Google Scholar 

  • Keshaviah A, Dellapasqua S, Rotmensz N et al (2007) CA15-3 and alkaline phosphatase as predictors for breast cancer recurrence: a combined analysis of seven International Breast Cancer Study Group trials. Ann Oncologia 18(4):701–708

    CAS  Google Scholar 

  • Khan SQ, Kelly D, Quinn P, Davies JE, Ng LL (2007) Myeloperoxidase aids prognostication together with N-terminal pro-B-type natriuretic peptide in high-risk patients with acute ST elevation myocardial infarction. Heart 93:826–831

    CAS  PubMed  Google Scholar 

  • Kim H, Scorilas A, Katsaros D et al (2001) Human kallikrein gene 5 (KLK5) expressions is an indicator of poor prognosis in ovarian cancer. Br J Cancer 84:643–650

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kos J, Werle B, Lah T, Brunner N (2000) Cysteine proteinases and their inhibitors in extracellular fluids: markers for diagnosis and prognosis in cancer. Int J Biol Markers 15:84–89

    CAS  PubMed  Google Scholar 

  • Kumar JK, Aronsson AC, Pilko G et al (2016) A clinical evaluation of the TK 210 ELISA in sera from breast cancer patients demonstrates high sensitivity and specificity in all stages of disease. Tumour Biol 37:11937–11945

    CAS  PubMed  PubMed Central  Google Scholar 

  • Lawrence JB, Oxvig C, Overgaard MT et al (1999) The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A. Proc Natl Acad Sci U S A 96:3149–3153

    CAS  PubMed  PubMed Central  Google Scholar 

  • Li J, Cheng ZJ, Liu Y et al (2015) Serum thioredoxin is a diagnostic marker for hepatocellular carcinoma. Oncotarget 6:9551–9563

    PubMed  PubMed Central  Google Scholar 

  • Liang SL, Chan DW (2007) Enzymes and related proteins as cancer biomarkers: a proteomic approach. Clin Chim Acta 381:93–97

    CAS  PubMed  PubMed Central  Google Scholar 

  • Liggett SB, Cresci S, Kelly RJ, Syed FM, Matkovich SJ, Hahn HS, Diwan A, Martini JS, Sparks L, Parekh RR, Spertus JA, Koch WJ, Kardia SL, Dorn GW 2nd (2008) A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure. Nat Med 14(5):510–517

    CAS  PubMed  PubMed Central  Google Scholar 

  • Lincoln DT, Al-Yatama F, Mohammed FM et al (2010) Thioredoxin and thioredoxinreductase expression in thyroid cancer depends on tumour aggressiveness. Anticancer Res 30:767–775

    PubMed  Google Scholar 

  • Löhr JM (2016) Clinical and laboratory diagnosis of chronic pancreatitis. Pancreapedia: the exocrine pancreas knowledge base. doi:https://doi.org/10.3998/panc.2016.14

  • Lopes LR, Elliott PM (2013) Genetics of heart failure. Biochim Biophys Acta 832(12):2451–2461

    Google Scholar 

  • Memarzadeh S, Kozak KR, Chang L et al (2002) Urokinase plasminogen activator receptor: prognostic biomarker for endometrial cancer. Proc Natl Acad Sci U S A 99:10647–10652

    PubMed  PubMed Central  Google Scholar 

  • Mohamed MM, Sloane BF (2006) Cysteine cathepsins: multifunctional enzymes in cancer. Nat Rev Cancer 6:764–775

    CAS  PubMed  Google Scholar 

  • Munnich A, Rötig A, Rio M (2012) Defects of the respiratory chain. Inborn metabolic diseases diagnosis and treatment. Springer, Berlin, pp 223–238

    Google Scholar 

  • Mythili S, Malathi N (2015) Diagnostic markers of acute myocardial infarction. Biomed Rep 3(6):743–748

    PubMed  PubMed Central  Google Scholar 

  • Newsome PN, Cramb R, Davison SM, Dillon JF, Foulerton M, Godfrey EM, Hall R, Harrower U, Hudson M, Langford A, Mackie A (2018) Guidelines on the management of abnormal liver blood tests. Gut 67(1):6–19

    PubMed  Google Scholar 

  • Oh HC, Kwon CI, El Hajj II, Easler JJ, Watkins J, Fogel EL, McHenry L, Sherman S, Zimmerman MK, Lehman GA (2017) The diagnostic value of pepsin detection in saliva for gastro-esophageal reflux disease: a preliminary study from China. BMC Gastroenterol 17(1):107

    Google Scholar 

  • Oxvig C, Sand O, Kristensen T, Kristensen L, Sottrup-Jensen L (1994) Isolation and characterization of circulating complex between human pregnancy-associated plasma protein-A and proform of eosinophil major basic protein. Biochim Biophys Acta 1201:415–423

    PubMed  Google Scholar 

  • Palermo C, Johanna AJ (2008) Cysteine cathepsin proteases as pharmacologicaltargets in cancer. Trends Pharmacol Sci 29(1):22–28

    CAS  PubMed  Google Scholar 

  • Paliouras M, Borgono C, Diamandis EP (2007) Human tissue kallikreins: the cancer biomarker family. Cancer Lett 249:61–79

    CAS  PubMed  Google Scholar 

  • Parrett M, Harris R, Joarder F, Ross M, Clausen K, Robertson F (1997) Cyclooxygenase-2 gene expression in human breast cancer. Int J Oncol 10:503–507

    CAS  PubMed  Google Scholar 

  • Pitkanen S, Robinson BH (1996) Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase. J Clin Invest 98:345–351

    CAS  PubMed  PubMed Central  Google Scholar 

  • Pratt DS, Kaplan MM (2000) Evaluation of abnormal liver-enzyme results in asymptomatic patients. New Eng J Med 342(17):1266–1271

    CAS  PubMed  Google Scholar 

  • Ramachandran J, Sajith KG, Priya S, Dutta AK, Balasubramanian KA (2015) Serum cholinesterase is an excellent biomarker of liver cirrhosis. Trop Gastroenterol 35(1):15–20

    Google Scholar 

  • Rao SR, Snaith AE, Marino D et al (2017) Tumour-derived alkaline phosphatase regulates tumour growth, epithelial plasticity and disease-free survival in metastatic prostate cancer. Br J Cancer 116:227–236

    CAS  PubMed  Google Scholar 

  • Romero-Alvira D, Roche E, Placer L (1996) Cardiomyopathies and oxidative stress. Med Hypotheses 47:137–144

    CAS  PubMed  Google Scholar 

  • Rosalki SB, Tarlow D, Rau D (1971) Plasma gamma-glutamyltranspeptidase elevation in patients receiving enzyme-inducing drugs. Lancet 298(7720):376–377

    Google Scholar 

  • Rucci N, Teti A (2010) Osteomimicry: how tumor cells try to deceive the bone. Front Biosci (Schol Ed) 2:907–915

    Google Scholar 

  • Saif MW, Alexander D, Wicox CM (2005) Serum alkaline phosphatase level as a prognostic tool in colorectal cancer: a study of 105 patients. J Appl Res 5:88–95

    CAS  PubMed  PubMed Central  Google Scholar 

  • Selenius M, Rundlöf AK, Olm E, Fernandes AP, Björnstedt M (2010) Selenium and the selenoprotein thioredoxin reductase in the prevention, treatment and diagnostics of cancer. Antioxid Redox Signal 12:867–880

    CAS  PubMed  Google Scholar 

  • Shimizu K, Yukawa T, Okita R, Saisho S, Maeda A, Nojima Y, Nakata M (2015) Cyclooxygenase-2 expression is a prognostic biomarker for non-small cell lung cancer patients treated with adjuvant platinum-based chemotherapy. World J Surg Oncol 13:21

    PubMed  PubMed Central  Google Scholar 

  • Shiomi H, Eguchi Y, Tani T, Kodama M, Hattori T (2000) Cellular distribution and clinical value of urokinase-type plasminogen activator, its receptor, and plasminogen activator inhibitor-2 in esophageal squamous cell carcinoma. Am J Pathol 156:567–575

    CAS  PubMed  PubMed Central  Google Scholar 

  • Sifrim D (2015) The role of salivary pepsin in the diagnosis of reflux. Gastroenterol Hepatol 11(6):417

    Google Scholar 

  • Singal PK, Kirshenbaum LA (1990) A relative deficit in antioxidant reserve may contribute in cardiac failure. Can J Cardiol 6:47–49

    CAS  PubMed  Google Scholar 

  • Singh N, Dhalla AK, Seneviratne C, Singal PK (1995) Oxidative stress and heart failure. Mol Cell Biochem 147:77–81

    CAS  PubMed  Google Scholar 

  • Sobolewski C, Cerella C, Dicato M, Ghibelli L, Diederich M (2010) The role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies. Int J Cell Biol 2010:215158

    PubMed  PubMed Central  Google Scholar 

  • Stefanini M (1985) Enzymes, isozymes, and enzyme variants in the diagnosis of cancer. A short review. Cancer 55:1931–1936

    CAS  PubMed  Google Scholar 

  • Thapa BR, Walia A (2007) Liver function tests and their interpretation. Indian J Pediatr 74(7):663–671

    CAS  PubMed  Google Scholar 

  • Tomlins SA, Mehra R, Rhodes DR et al (2007) Integrative molecular concept modeling of prostate cancer progression. Nat Genet 39:41–51

    CAS  PubMed  Google Scholar 

  • Tracy C, Warren JS, Szulik M, Wang L, Garcia J, Makaju A, Russell K, Miller M, Franklin S (2018) The Smyd family of methyltransferases: role in cardiac and skeletal muscle physiology and pathology. Curr Opin Physiol 1:140–152

    PubMed  Google Scholar 

  • Turk B (2006) Targeting proteases: successes, failures and future prospects. Nat Rev Drug Discov 5:785–799

    CAS  PubMed  Google Scholar 

  • Turk D, Guncar G (2003) Lysosomal cysteine proteases (cathepsins): promising drugtargets. Acta Crystallogr D Biol Crystallogr 59:203–213

    PubMed  Google Scholar 

  • Ullah MF, Aatif M (2009) The footprints of cancer development: cancer biomarkers. Cancer Treat Rev 3:193–200

    Google Scholar 

  • Wang D, Dubois RN (2010) The role of COX-2 in intestinal inflammation and colorectal cancer. Oncogene 29:781–788

    CAS  PubMed  Google Scholar 

  • Wang J, Zhang S, Jin Y, Qin G, Yu L, Zhang J (2007) Elevated levels of platelet-monocyte aggregates and related circulating biomarkers in patients with acute coronary syndrome. Int J Cardiol 115:361–365

    PubMed  Google Scholar 

  • Wang Y, Jiang X, Dong S et al (2016) Serum TK1 is a more reliable marker than CEA and AFP for cancer screening in a study of 56,286 people. Cancer Biomark 16:529–536

    PubMed  Google Scholar 

  • Warren JS, Tracy CM, Miller MR et al (2018) Histone methyltransferase Smyd1 regulates mitochondrial energetics in the heart. Proc Natl Acad Sci U S A 115(33):E7871–E7880

    CAS  PubMed  PubMed Central  Google Scholar 

  • Whitfield JB (2001) Gamma glutamyltransferase. Crit Rev Clin Lab Sci 38(4):263–355

    CAS  PubMed  Google Scholar 

  • World Health Organization (WHO) working group, corp-author. The establishment of ischaemic heart disease registers (report of the fifth working group) WHO Reg Publ Eur Ser, Copenhagen. 1972;821(suppl 5)

    Google Scholar 

  • Wortmann SB, Duran M, Anikster Y, Barth PG, Sperl W, Zschocke J et al (2013) Inborn errors of metabolism with 3-methylglutaconic aciduria as discriminative feature: proper classification and nomenclature. J Inherit Metab Dis 36:923–928

    CAS  PubMed  Google Scholar 

  • Wu AH, Wang XM, Gornet TG, OrdonezLlanos J (1992) Creatine kinase MB isoforms in patients with skeletal muscle injury: Ramifications for early detection of acute myocardial infarction. Clin Chem 38:2396–2400

    CAS  PubMed  Google Scholar 

  • Yang B, Jia L, Guo Q, Ren H, Hu Y, Xie T (2016) Clinicopathological and prognostic significance of cyclooxygenase-2 expression in head and neck cancer: a meta-analysis. Oncotarget 7:47265–47277

    PubMed  PubMed Central  Google Scholar 

  • Yousef GM, Stephan C, Scorilas A et al (2003) Differential expression of the human kallikrein gene 14 (KLK14) in normal and cancerous prostatic tissues. Prostate 56:287–292

    CAS  PubMed  Google Scholar 

  • Zarghi A, Arfaei S (2011) Selective COX-2 inhibitors: a review of their structure-activity relationships. Iran J Pharm Res 10(4):655–683

    CAS  PubMed  PubMed Central  Google Scholar 

  • Zhu X, Wang X, Chen X (2017) The diagnostic value of serum microRNA-183 and TK1 as biomarkers for colorectal cancer diagnosis. Open Life Sci 12:243–247

    CAS  Google Scholar 

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Acknowledgments

We thankfully acknowledge the authors and the publishers of the articles from where the Fig. 1 has been reproduced, and note that since a brief overview on the subject was attempted, some worthwhile studies and relevant observations may have been inadvertently missed.

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  1. Faculty of Applied Medical Science, Prince Fahd Research Chair, Department of Medical Laboratory Technology, University of Tabuk, Tabuk, Saudi Arabia

    Mohammad Fahad Ullah, Showket H. Bhat, Muhammad Tariq & Faisel M. Abuduhier

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  1. Mohammad Fahad Ullah
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  2. Showket H. Bhat
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Correspondence to Mohammad Fahad Ullah .

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Editors and Affiliations

  1. Department of Biochemistry, Aligarh Muslim University, Aligarh, India

    Qayyum Husain

  2. Department of Medical Laboratory Technology, FAMS, University of Tabuk, Tabuk, Saudi Arabia

    Mohammad Fahad Ullah

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Fahad Ullah, M., Bhat, S.H., Tariq, M., Abuduhier, F.M. (2019). Clinical Significance of Enzymes in Disease and Diagnosis. In: Husain, Q., Ullah, M. (eds) Biocatalysis. Springer, Cham. https://doi.org/10.1007/978-3-030-25023-2_11

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