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Lymph Nodes and Spleen

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Atlas of Cytopathology and Radiology

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Abstract

The main indication for fine needle aspiration (FNA) and core needle biopsy (CNB) of lymph nodes or spleen is to rule out metastatic disease of either a known or unknown primary for staging or for local or diffuse lymphadenopathy in order to exclude lymphoma. We describe the radiographic features, cytomorphology of FNA or touch preparation of the cores, histology of CNB, immunohistochemical stains, flow cytometry, and molecular studies of common hematopoietic lesions and non-neoplastic lesions as well as metastatic malignancy.

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References

  1. Steinkamp HJ, Cornehl M, Hosten N, Pegios W, Vogl T, Felix R. Cervical lymphadenopathy: ratio of long- to short-axis diameter as a predictor of malignancy. Br J Radiol. 1995;68:266–70.

    Article  CAS  PubMed  Google Scholar 

  2. Kwon SY, Kim TK, Kim YS, Lee KY, Lee NJ, Seol HY. CT findings in Kikuchi disease: analysis of 96 cases. Am J Neuroradiol. 2004;25:1099–102.

    PubMed  PubMed Central  Google Scholar 

  3. Tsujikawa T, Tsuchida T, Imamura Y, Kobayashi M, Asahi S, Shimizu K, et al. Kikuchi-Fujimoto disease: PET/CT assessment of a rare cause of cervical lymphadenopathy. Clin Nucl Med. 2011;36:661–4.

    Article  PubMed  Google Scholar 

  4. Khanna R, Sharma AD, Khanna S, Kumar M, Shukla RC. Usefulness of ultrasonography for the evaluation of cervical lymphadenopathy. World J Surg Oncol. 2011;9:29.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Choi YJ, Lee JH, Baek JH. Ultrasound elastography for evaluation of cervical lymph nodes. Ultrasonography. 2015;34:157–64.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Youk JH, Kim EK, Ko KH, Kim MJ. Sonographic features of axillary lymphadenopathy caused by Kikuchi disease. J Ultrasound Med. 2008;27:847–53.

    Article  PubMed  Google Scholar 

  7. Eisenmenger LB, Wiggins RH. Imaging of head and neck lymph nodes. Radiol Clin N Am. 2015;53:115–32.

    Article  PubMed  Google Scholar 

  8. Holzapfel K, Duetsch S, Fauser C, Eiber M, Rummeny EJ, Gaa J. Value of diffusion-weighted MR imaging in the differentiation between benign and malignant cervical lymph nodes. Eur J Radiol. 2009;72:381–7.

    Article  PubMed  Google Scholar 

  9. Si J, Huang S, Shi H, Liu Z, Hu Q, Wang G, et al. Usefulness of 3T diffusion-weighted MRI for discrimination of reactive and metastatic cervical lymph nodes in patients with oral squamous cell carcinoma: a pilot study. Dentomaxillofac Radiol. 2014;43:20130202.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Asano S. Granulomatous lymphadenitis. J Clin Exp Hematol. 2012;52:1–16.

    Article  Google Scholar 

  11. Armitage JO, Weisenburger DD. New approach to classifying non-Hodgkin’s lymphomas: clinical features of the major histologic subtypes. Non-Hodgkin’s Lymphoma Classification Project. J Clin Oncol. 1998;16:2780–95.

    Article  CAS  PubMed  Google Scholar 

  12. Hill BT, Weil AC, Kalaycio M, Cook JR. Pulmonary involvement by chronic lymphocytic leukemia/small lymphocytic lymphoma is a specific pathologic finding independent of inflammatory infiltration. Leuk Lymphoma. 2012;53:589–95.

    Article  PubMed  Google Scholar 

  13. Ghofrani M, Tantiwongkosi B, Smith AS, Wasdahl DA. Richter transformation of chronic lymphocytic leukemia presenting as a dural-based non-Hodgkin lymphoma mass. Am J Neuroradiol. 2007;28:318–20.

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Mauro FR, Chauvie S, Paoloni F, Biggi A, Cimino G, Rago A, et al. Diagnostic and prognostic role of PET/CT in patients with chronic lymphocytic leukemia and progressive disease. Leukemia. 2015;29:1360–5.

    Article  CAS  PubMed  Google Scholar 

  15. Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Dohner H, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood. 2008;111:5446–56.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Project BTN-HsLC. A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin’s lymphoma. The non-Hodgkin’s lymphoma classification project. Blood. 1997;89:3909–18.

    Article  Google Scholar 

  17. Hayashi D, Lee JC, Devenney-Cakir B, Zaim S, Ounadjela S, Solal-Celigny P, et al. Follicular non-Hodgkin’s lymphoma. Clin Radiol. 2010;65:408–20.

    Article  CAS  PubMed  Google Scholar 

  18. Barrington SF, Mikhaeel NG, Kostakoglu L, Meignan M, Hutchings M, Mueller SP, et al. Role of imaging in the staging and response assessment of lymphoma: consensus of the International Conference on Malignant Lymphomas Imaging Working Group. J Clin Oncol. 2014;32:3048–58.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Rowley JD. Chromosome studies in the non-Hodgkin’s lymphomas: the role of the 14;18 translocation. J Clin Oncol. 1988;6:919–25.

    Article  CAS  PubMed  Google Scholar 

  20. Korsmeyer SJ. Bcl-2 initiates a new category of oncogenes: regulators of cell death. Blood. 1992;80:879–86.

    Article  CAS  PubMed  Google Scholar 

  21. Zucca E, Bertoni F, Roggero E, Cavalli F. The gastric marginal zone B-cell lymphoma of MALT type. Blood. 2000;96:410–9.

    Article  CAS  PubMed  Google Scholar 

  22. Hussell T, Isaacson PG, Crabtree JE, Spencer J. The response of cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori. Lancet. 1993;342:571–4.

    Article  CAS  PubMed  Google Scholar 

  23. Swerdlow S, Campo E, Harris NL, Jaffe E, Pileri S, Stein S, Thiele J, Vardiman J, editors. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon: International Agency for Research on Cancer (IARC); 2008.

    Google Scholar 

  24. Dierlamm J, Baens M, Stefanova-Ouzounova M, Hinz K, Wlodarska I, Maes B, et al. Detection of t(11;18)(q21;q21) by interphase fluorescence in situ hybridization using API2 and MLT specific probes. Blood. 2000;96:2215–8.

    Article  CAS  PubMed  Google Scholar 

  25. Mozos A, Royo C, Hartmann E, De Jong D, Baro C, Valera A, et al. SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype. Haematologica. 2009;94:1555–62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Zukerberg LR, Yang WI, Arnold A, Harris NL. Cyclin D1 expression in non-Hodgkin's lymphomas. Detection by immunohistochemistry. Am J Clin Pathol. 1995;103:756–60.

    Article  CAS  PubMed  Google Scholar 

  27. Ahuja AT, Ying M. Sonographic evaluation of cervical lymph nodes. Am J Roentgenol. 2005;184:1691–9.

    Article  Google Scholar 

  28. Tateishi U, Muller NL, Johkoh T, Onishi Y, Arai Y, Satake M, et al. Primary mediastinal lymphoma: characteristic features of the various histological subtypes on CT. J Comput Assist Tomogr. 2004;28:782–9.

    Article  PubMed  Google Scholar 

  29. Cronin CG, Swords R, Truong MT, Viswanathan C, Rohren E, Giles FJ, et al. Clinical utility of PET/CT in lymphoma. Am J Roentgenol. 2010;194:W91–103.

    Article  Google Scholar 

  30. Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Delabie J, Ott G, et al. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood. 2004;103:275–82.

    Article  CAS  PubMed  Google Scholar 

  31. Alizadeh AA, Eisen MB, Davis RE, Ma C, Lossos IS, Rosenwald A, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature. 2000;403:503–11.

    Article  CAS  PubMed  Google Scholar 

  32. Kramer MH, Hermans J, Wijburg E, Philippo K, Geelen E, van Krieken JH, et al. Clinical relevance of BCL2, BCL6, and MYC rearrangements in diffuse large B-cell lymphoma. Blood. 1998;92:3152–62.

    Article  CAS  PubMed  Google Scholar 

  33. Johnson NA, Savage KJ, Ludkovski O, Ben-Neriah S, Woods R, Steidl C, et al. Lymphomas with concurrent BCL2 and MYC translocations: the critical factors associated with survival. Blood. 2009;114:2273–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Vitolo U, Gaidano G, Botto B, Volpe G, Audisio E, Bertini M, et al. Rearrangements of bcl-6, bcl-2, c-myc and 6q deletion in B-diffuse large-cell lymphoma: clinical relevance in 71 patients. Ann Oncol. 1998;9:55–61.

    Article  CAS  PubMed  Google Scholar 

  35. Rajkumar SV, Dimopoulos MA, Palumbo A, Blade J, Merlini G, Mateos MV, et al. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol. 2014;15:e538–48.

    Article  PubMed  Google Scholar 

  36. Treon SP, Xu L, Yang G, Zhou Y, Liu X, Cao Y, et al. MYD88 L265P somatic mutation in Waldenstrom’s macroglobulinemia. N Engl J Med. 2012;367:826–33.

    Article  CAS  PubMed  Google Scholar 

  37. Varettoni M, Arcaini L, Zibellini S, Boveri E, Rattotti S, Riboni R, et al. Prevalence and clinical significance of the MYD88 (L265P) somatic mutation in Waldenstrom’s macroglobulinemia and related lymphoid neoplasms. Blood. 2013;121:2522–8.

    Article  CAS  PubMed  Google Scholar 

  38. Vose J, Armitage J, Weisenburger D, International TCLP. International peripheral T-cell and natural killer/T-cell lymphoma study: pathology findings and clinical outcomes. J Clin Oncol. 2008;26:4124–30.

    Article  PubMed  Google Scholar 

  39. Weisenburger DD, Savage KJ, Harris NL, Gascoyne RD, Jaffe ES, MacLennan KA, et al. Peripheral T-cell lymphoma, not otherwise specified: a report of 340 cases from the International Peripheral T-cell Lymphoma Project. Blood. 2011;117:3402–8.

    Article  CAS  PubMed  Google Scholar 

  40. Murphy EL, Hanchard B, Figueroa JP, Gibbs WN, Lofters WS, Campbell M, et al. Modelling the risk of adult T-cell leukemia/lymphoma in persons infected with human T-lymphotropic virus type I. Int J Cancer. 1989;43:250–3.

    Article  CAS  PubMed  Google Scholar 

  41. Weiss LM, Jaffe ES, Liu XF, Chen YY, Shibata D, Medeiros LJ. Detection and localization of Epstein-Barr viral genomes in angioimmunoblastic lymphadenopathy and angioimmunoblastic lymphadenopathy-like lymphoma. Blood. 1992;79:1789–95.

    Article  CAS  PubMed  Google Scholar 

  42. Anagnostopoulos I, Hummel M, Finn T, Tiemann M, Korbjuhn P, Dimmler C, et al. Heterogeneous Epstein-Barr virus infection patterns in peripheral T-cell lymphoma of angioimmunoblastic lymphadenopathy type. Blood. 1992;80:1804–12.

    Article  CAS  PubMed  Google Scholar 

  43. Odejide O, Weigert O, Lane AA, Toscano D, Lunning MA, Kopp N, et al. A targeted mutational landscape of angioimmunoblastic T-cell lymphoma. Blood. 2014;123:129–36.

    Article  CAS  Google Scholar 

  44. Weiss LM, Strickler JG, Dorfman RF, Horning SJ, Warnke RA, Sklar J. Clonal T-cell populations in angioimmunoblastic lymphadenopathy and angioimmunoblastic lymphadenopathy-like lymphoma. Am J Pathol. 1986;122:392–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  45. Feller AC, Griesser H, Schilling CV, Wacker HH, Dallenbach F, Bartels H, et al. Clonal gene rearrangement patterns correlate with immunophenotype and clinical parameters in patients with angioimmunoblastic lymphadenopathy. Am J Pathol. 1988;133:549–56.

    CAS  PubMed  PubMed Central  Google Scholar 

  46. Toma P, Granata C, Rossi A, Garaventa A. Multimodality imaging of Hodgkin disease and non-Hodgkin lymphomas in children. Radiographics. 2007;27:1335–54.

    Article  PubMed  Google Scholar 

  47. Bae YA, Lee KS. Cross-sectional evaluation of thoracic lymphoma. Radiol Clin N Am. 2008;46:253–64.. viii

    Article  PubMed  Google Scholar 

  48. Jhanwar YS, Straus DJ. The role of PET in lymphoma. J Nucl Med. 2006;47:1326–34.

    PubMed  Google Scholar 

  49. Elsayes KM, Narra VR, Mukundan G, Lewis JS, Menias CO, Heiken JP. MR imaging of the spleen: spectrum of abnormalities. Radiographics. 2005;25:967–82.

    Article  PubMed  Google Scholar 

  50. Ahuja AT, Ying M, Ho SY, Antonio G, Lee YP, King AD, et al. Ultrasound of malignant cervical lymph nodes. Cancer Imaging. 2008;8:48–56.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Herndier BG, Sanchez HC, Chang KL, Chen YY, Weiss LM. High prevalence of Epstein-Barr virus in the Reed-Sternberg cells of HIV-associated Hodgkin’s disease. Am J Pathol. 1993;142:1073–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  52. Wang E, Hutchinson CB, Huang Q, Sebastian S, Rehder C, Kanaly A, et al. Histiocytic sarcoma arising in indolent small B-cell lymphoma: report of two cases with molecular/genetic evidence suggestive of a ‘transdifferentiation’ during the clonal evolution. Leuk Lymphoma. 2010;51:802–12.

    Article  CAS  PubMed  Google Scholar 

  53. Castro EC, Blazquez C, Boyd J, Correa H, de Chadarevian JP, Felgar RE, et al. Clinicopathologic features of histiocytic lesions following ALL, with a review of the literature. Pediatr Dev Pathol. 2010;13:225–37.

    Article  PubMed  Google Scholar 

  54. Arico M, Girschikofsky M, Genereau T, Klersy C, McClain K, Grois N, et al. Langerhans cell histiocytosis in adults. Report from the International Registry of the Histiocyte Society. Eur J Cancer. 2003;39:2341–8.

    Article  CAS  PubMed  Google Scholar 

  55. Gotz G, Fichter J. Langerhans’-cell histiocytosis in 58 adults. Eur J Med Res. 2004;9:510–4.

    CAS  PubMed  Google Scholar 

  56. Go H, Jeon YK, Huh J, Choi SJ, Choi YD, Cha HJ, et al. Frequent detection of BRAF (V600E) mutations in histiocytic and dendritic cell neoplasms. Histopathology. 2014;65:261–72.

    Article  PubMed  Google Scholar 

  57. Badalian-Very G, Vergilio JA, Degar BA, MacConaill LE, Brandner B, Calicchio ML, et al. Recurrent BRAF mutations in Langerhans cell histiocytosis. Blood. 2010;116:1919–23.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. King DM. Imaging of metastatic melanoma. Cancer Imaging. 2006;6:204–8.

    Article  PubMed  Google Scholar 

  59. Fishman EK, Kuhlman JE, Schuchter LM, Miller JA, Magid D. CT of malignant melanoma in the chest, abdomen, and musculoskeletal system. Radiographics. 1990;10:603–20.

    Article  CAS  PubMed  Google Scholar 

  60. Patnana M, Bronstein Y, Szklaruk J, Bedi DG, Hwu WJ, Gershenwald JE, et al. Multimethod imaging, staging, and spectrum of manifestations of metastatic melanoma. Clin Radiol. 2011;66:224–36.

    Article  CAS  PubMed  Google Scholar 

  61. Strobel K, Dummer R, Husarik DB, Perez Lago M, Hany TF, Steinert HC. High-risk melanoma: accuracy of FDG PET/CT with added CT morphologic information for detection of metastases. Radiology. 2007;244:566–74.

    Article  PubMed  Google Scholar 

  62. Saiag P, Bernard M, Beauchet A, Bafounta ML, Bourgault-Villada I, Chagnon S. Ultrasonography using simple diagnostic criteria vs palpation for the detection of regional lymph node metastases of melanoma. Arch Dermatol. 2005;141:183–9.

    Article  PubMed  Google Scholar 

  63. Civardi GVD, Berte R, Giorgio A, Filice C, Caremani M, Caturelli E, et al. Ultrasound-guided fine needle biopsy of the spleen: high clinical efficacy and low risk in a multicenter Italian Study. Am J Hematol. 2001;67:93–9.

    Article  CAS  PubMed  Google Scholar 

  64. Benter T, Kluhs L, Teichgraber U. Sonography of the spleen. J Ultrasound Med. 2011;30:1281–93.

    Article  PubMed  Google Scholar 

  65. Rabushka LS, Kawashima A, Fishman EK. Imaging of the spleen: CT with supplemental MR examination. Radiographics. 1994;14:307–32.

    Article  CAS  PubMed  Google Scholar 

  66. Robertson F, Leander P, Ekberg O. Radiology of the spleen. Eur Radiol. 2001;11:80–95.

    Article  CAS  PubMed  Google Scholar 

  67. Raber EL, Haba J, Beck P. Splenic sarcoidosis: a case report and review of the imaging findings of multiple incidental splenic lesions as the initial presentation of sarcoidosis. Can J Gastroenterol. 2011;25:477–8.

    Article  PubMed  PubMed Central  Google Scholar 

  68. Warshauer DM, Lee JK. Imaging manifestations of abdominal sarcoidosis. Am J Roentgenol. 2004;182:15–28.

    Article  Google Scholar 

  69. Koyama T, Ueda H, Togashi K, Umeoka S, Kataoka M, Nagai S. Radiologic manifestations of sarcoidosis in various organs. Radiographics. 2004;24:87–104.

    Article  PubMed  Google Scholar 

  70. Freeman JL, Jafri SZ, Roberts JL, Mezwa DG, Shirkhoda A. CT of congenital and acquired abnormalities of the spleen. Radiographics. 1993;13:597–610.

    Article  CAS  PubMed  Google Scholar 

  71. Caremani M, Occhini U, Caremani A, Tacconi D, Lapini L, Accorsi A, et al. Focal splenic lesions: US findings. J Ultrasound. 2013;16:65–74.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  72. Urrutia M, Mergo PJ, Ros LH, Torres GM, Ros PR. Cystic masses of the spleen: radiologic-pathologic correlation. Radiographics. 1996;16:107–29.

    Article  CAS  PubMed  Google Scholar 

  73. Ishida H, Konno K, Ishida J, Naganuma H, Komatsuda T, Sato M, et al. Splenic lymphoma: differentiation from splenic cyst with ultrasonography. Abdom Imaging. 2001;26:529–32.

    Article  CAS  PubMed  Google Scholar 

  74. von Herbay A, Barreiros AP, Ignee A, Westendorff J, Gregor M, Galle PR, et al. Contrast-enhanced ultrasonography with SonoVue: differentiation between benign and malignant lesions of the spleen. J Ultrasound Med. 2009;28:421–34.

    Article  Google Scholar 

  75. Gorg C. The forgotten organ: contrast enhanced sonography of the spleen. Eur J Radiol. 2007;64:189–201.

    Article  PubMed  Google Scholar 

  76. Thipphavong S, Duigenan S, Schindera ST, Gee MS, Philips S. Nonneoplastic, benign, and malignant splenic diseases: cross-sectional imaging findings and rare disease entities. Am J Roentgenol. 2014;203:315–22.

    Article  Google Scholar 

  77. Mateo M, Mollejo M, Villuendas R, Algara P, Sanchez-Beato M, Martinez P, et al. 7q31-32 allelic loss is a frequent finding in splenic marginal zone lymphoma. Am J Pathol. 1999;154:1583–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  78. Tiacci E, Trifonov V, Schiavoni G, Holmes A, Kern W, Martelli MP, et al. BRAF mutations in hairy-cell leukemia. N Engl J Med. 2011;364:2305–15.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  79. Tiacci E, Schiavoni G, Forconi F, Santi A, Trentin L, Ambrosetti A, et al. Simple genetic diagnosis of hairy cell leukemia by sensitive detection of the BRAF-V600E mutation. Blood. 2012;119:192–5.

    Article  CAS  PubMed  Google Scholar 

  80. Kotlyar DS, Osterman MT, Diamond RH, Porter D, Blonski WC, Wasik M, et al. A systematic review of factors that contribute to hepatosplenic T-cell lymphoma in patients with inflammatory bowel disease. Clin Gastroenterol Hepatol. 2011;9:36–41 e1.

    Article  CAS  PubMed  Google Scholar 

  81. Kristensen T, Vestergaard H, Bindslev-Jensen C, Moller MB, Broesby-Olsen S, Mastocytosis Centre OUH. Sensitive KIT D816V mutation analysis of blood as a diagnostic test in mastocytosis. Am J Hematol. 2014;89:493–8.

    Article  CAS  PubMed  Google Scholar 

  82. Arock M, Sotlar K, Akin C, Broesby-Olsen S, Hoermann G, Escribano L, et al. KIT mutation analysis in mast cell neoplasms: recommendations of the European Competence Network on Mastocytosis. Leukemia. 2015;29:1223–32.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  83. Du J, Shen Q, Yin H, Zhou X, Wu B. Littoral cell angioma of the spleen: report of three cases and literature review. Int J Clin Exp Pathol. 2015;8:8516–20.

    PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Northwestern University, Feinberg School of Medicine, Northwestern Memorial Hospital, Chicago, IL, USA

    Xiaoqi Lin

  2. Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA

    Juehua Gao

  3. Department of Pathology, Thomas Health System, South Charleston, WV, USA

    John K. S. S. Philip

  4. Department of Radiology, McGaw Medical Center, Northwestern University, Chicago, IL, USA

    Rosewell V. Mackey

  5. Department of Radiology, Section of Vascular and Interventional Radiology, Northwestern University, Chicago, IL, USA

    Rehan Ali

  6. Department of Pathology, Northwestern Medicine, Chicago, IL, USA

    Ahsun Riaz

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  1. Xiaoqi Lin
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  2. Juehua Gao
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  3. John K. S. S. Philip
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  4. Rosewell V. Mackey
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  5. Rehan Ali
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  6. Ahsun Riaz
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Correspondence to Xiaoqi Lin .

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Editors and Affiliations

  1. Northwestern University Feinberg School of Medicine, Northwestern Memorial Hospital, Chicago, IL, USA

    Ritu Nayar

  2. Northwestern University Feinberg School of Medicine, Northwestern Memorial Hospital, Chicago, IL, USA

    Xiaoqi Lin

  3. Northshore Medical Group, Evanston Hospital, Evanston, IL, USA

    Ajit S. Paintal

  4. Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Ramona Gupta

  5. Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Albert A. Nemcek Jr.

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Lin, X., Gao, J., Philip, J.K.S.S., Mackey, R.V., Ali, R., Riaz, A. (2020). Lymph Nodes and Spleen. In: Nayar, R., Lin, X., Paintal, A., Gupta, R., Nemcek Jr., A. (eds) Atlas of Cytopathology and Radiology. Springer, Cham. https://doi.org/10.1007/978-3-030-24756-0_4

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