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Role of Oral Supplements: When and How to Choose

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Hair and Scalp Treatments

Abstract

People commonly inquire about vitamin and mineral supplementation and diet as a means to prevent or manage dermatological diseases and, in particular, hair loss. Answering these queries is frequently challenging, given the enormous and conflicting evidence that exists on this subject. There are several reasons to suspect a role for micronutrients in non-scarring alopecia. Micronutrients are major elements in the normal hair follicle cycle, playing a role in cellular turnover. The role of nutrition and diet in treating hair loss represents a dynamic and growing area of inquiry. This chapter summarizes the role of vitamins and minerals in non-scarring alopecia. Micronutrients such as vitamins and minerals play an important, but not entirely clear role in normal hair follicle development and immune cell function. Deficiency of such micronutrients may represent a modifiable risk factor associated with development, prevention, and treatment of alopecia.

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References

  1. Vitamins and Minerals: B Vitamins and Folic Acid NHS Choices: National Health Service; 2017. Available from: https://www.nhs.uk/conditions/vitamins-and-minerals/vitamin-b/.

  2. Board IoMFaN. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper. iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, DC: National Academies Press; 2001.

    Google Scholar 

  3. Yamamoto K, Sadahito K, Yoshikawa M, Nobuyuki O, Mikami O, Yamada M, et al. Hyena disease (premature physeal closure) in calves due to overdose of vitamins A, D3, E. Vet Hum Toxicol. 2003;45(2):85–7.

    PubMed  Google Scholar 

  4. McLaren DSLN, Duthie G, Bolton-Smith C. Fat soluble vitamins. In: Garrow JS, James WPT, editors. Human nutrition, dietetics. 9th ed. Edinburgh: Churchill Livingstone; 1993.

    Google Scholar 

  5. Shmunes E. Hypervitaminosis A in a patient with alopecia receiving renal dialysis. Arch Dermatol. 1979;115(7):882–3.

    CAS  PubMed  Google Scholar 

  6. Cheruvattath R, Orrego M, Gautam M, Byrne T, Alam S, Voltchenok M, et al. Vitamin A toxicity: when one a day doesn’t keep the doctor away. Liver Transpl. 2006;12(12):1888–91.

    PubMed  Google Scholar 

  7. Kmiec ML, Pajor A, Broniarczyk-Dyla G. Evaluation of biophysical skin parameters and assessment of hair growth in patients with acne treated with isotretinoin. Postepy Dermatol Alergol. 2013;30(6):343–9.

    PubMed  PubMed Central  Google Scholar 

  8. Board IoMFaN. Dietary reference intakes: thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. Washington, DC: National Academies Press; 1998.

    Google Scholar 

  9. Said HM, Ross AC. Riboflavin. In: Modern nutrition in health and disease. 11th ed. Baltimore: Lippincott Williams & Wilkins; 2014. p. 325–30.

    Google Scholar 

  10. Rivlin RS. Riboflavin. In: Encyclopedia of dietary supplements. London and New York: Informa Healthcare; 2010. p. 691–9.

    Google Scholar 

  11. Mock DM. Biotin. In: Encyclopedia of dietary supplements. 2nd ed. London and New York: Informa Healthcare; 2010. p. 43–51.

    Google Scholar 

  12. Tzellos TG, Tahmatzidis DK, Lallas A, Apostolidou K, Goulis DG. Pernicious anemia in a patient with type 1 diabetes mellitus and alopecia areata universalis. J Diabetes Complicat. 2009;23(6):434–7.

    PubMed  Google Scholar 

  13. FDA. The FDA warns that biotin may interfere with lab tests: FDA safety communication U.S. Food & Drug Administration: U.S. Department of Health and Human Services; 2017 (updated 28 Nov 2017). Available from: https://www.fda.gov/medicaldevices/safety/alertsandnotices/ucm586505.htm.

  14. Samarasinghe S, Meah F, Singh V, Basit A, Emanuele N, Emanuele MA, et al. Biotin interference with routine clinical immunoassays: understand the causes and mitigate the risks. Endocr Pract. 2017;23(8):989–98.

    PubMed  Google Scholar 

  15. Wijeratne NG, Doery JC, Lu ZX. Positive and negative interference in immunoassays following biotin ingestion: a pharmacokinetic study. Pathology. 2012;44(7):674–5.

    PubMed  Google Scholar 

  16. Trambas CM, Sikaris KA, Lu ZX. More on biotin treatment mimicking Graves’ disease. N Engl J Med. 2016;375(17):1698.

    PubMed  Google Scholar 

  17. Batista MC, Ferreira CES, Faulhaber ACL, Hidal JT, Lottenberg SA, Mangueira CLP. Biotin interference in immunoassays mimicking subclinical Graves’ disease and hyperestrogenism: a case series. Clin Chem Lab Med. 2017;55(6):e99–e103.

    CAS  PubMed  Google Scholar 

  18. Williams GR, Cervinski MA, Nerenz RD. Assessment of biotin interference with qualitative point-of-care hCG test devices. Clin Biochem. 2018;53:168–70.

    CAS  PubMed  Google Scholar 

  19. Zempleni J, Wijeratne S, Kuroishi T. Biotin. In: Present knowledge in nutrition. 10th ed. Washington, DC: Wiley-Blackwell; 2012. p. 359–74.

    Google Scholar 

  20. Boccaletti V, Zendri E, Giordano G, Gnetti L, De Panfilis G. Familial uncombable hair syndrome: ultrastructural hair study and response to biotin. Pediatr Dermatol. 2007;24(3):E14–6.

    CAS  PubMed  Google Scholar 

  21. Shelley WB, Shelley ED. Uncombable hair syndrome: observations on response to biotin and occurrence in siblings with ectodermal dysplasia. J Am Acad Dermatol. 1985;13(1):97–102.

    CAS  PubMed  Google Scholar 

  22. Trueb RM. Serum biotin levels in women complaining of hair loss. Int J Trichology. 2016;8(2):73–7.

    PubMed  PubMed Central  Google Scholar 

  23. Durusoy C, Ozenli Y, Adiguzel A, Budakoglu IY, Tugal O, Arikan S, et al. The role of psychological factors and serum zinc, folate and vitamin B12 levels in the aetiology of trichodynia: a case-control study. Clin Exp Dermatol. 2009;34(7):789–92.

    CAS  PubMed  Google Scholar 

  24. Bailey RL, Dodd KW, Gahche JJ, Dwyer JT, McDowell MA, Yetley EA, et al. Total folate and folic acid intake from foods and dietary supplements in the United States: 2003-2006. Am J Clin Nutr. 2010;91(1):231–7.

    CAS  PubMed  Google Scholar 

  25. Harvard T.H. Chan School of Public Health. Three of the B vitamins: folate, vitamin B6, and vitamin B12. Boston: Harvard T.H. Chan School of Public Health; 2018.. (updated 8 Aug 2018).

    Google Scholar 

  26. Cheung EJ, Sink JR, English JC III. Vitamin and mineral deficiencies in patients with telogen effluvium: a retrospective cross-sectional study. J Drugs Dermatol. 2016;15(10):1235–7.

    CAS  PubMed  Google Scholar 

  27. Valdes F. [Vitamin C]. Actas Dermosifiliogr. 2006;97(9):557–68.

    Google Scholar 

  28. Fleming JD, Martin B, Card DJ, Mellerio JE. Pain, purpura and curly hairs. Clin Exp Dermatol. 2013;38(8):940–2.

    CAS  PubMed  Google Scholar 

  29. D’Aurizio F, Villalta D, Metus P, Doretto P, Tozzoli R. Is vitamin D a player or not in the pathophysiology of autoimmune thyroid diseases? Autoimmun Rev. 2015;14(5):363–9.

    PubMed  Google Scholar 

  30. Zhang X, Wang W, Li Y, Wang H, Liu R, Zhu L. Serum 25-hydroxyvitamin D status in chinese children with vitiligo: a case-control study. Clin Pediatr (Phila). 2018;57(7):802–5.

    Google Scholar 

  31. Djeraba Z, Benlabidi F, Djaballah-Ider FZ, Medjeber O, Arroul-Lammali A, Belguendouz H, et al. Vitamin D status in Algerian Behcet’s disease patients: an immunomodulatory effect on NO pathway. Immunopharmacol Immunotoxicol. 2017;39(4):243–50.

    CAS  PubMed  Google Scholar 

  32. Wang LM, Zheng ZH, Li TF, Han LS, He YJ, Zhang YL, et al. 25-hydroxyvitamin D is associated with metabolic syndrome among premenopausal women with systemic lupus erythematosus in China. Lupus. 2017;26(4):403–9.

    CAS  PubMed  Google Scholar 

  33. Vasile M, Corinaldesi C, Antinozzi C, Crescioli C. Vitamin D in autoimmune rheumatic diseases: a view inside gender differences. Pharmacol Res. 2017;117:228–41.

    CAS  PubMed  Google Scholar 

  34. Thompson JM, Mirza MA, Park MK, Qureshi AA, Cho E. The role of micronutrients in alopecia areata: a review. Am J Clin Dermatol. 2017;18(5):663–79.

    PubMed  PubMed Central  Google Scholar 

  35. Takeda E, Kuroda Y, Saijo T, Naito E, Kobashi H, Yokota I, et al. 1 Alpha-hydroxyvitamin D3 treatment of three patients with 1,25-dihydroxyvitamin D-receptor-defect rickets and alopecia. Pediatrics. 1987;80(1):97–101.

    CAS  PubMed  Google Scholar 

  36. Malloy PJ, Pike JW, Feldman D. The vitamin D receptor and the syndrome of hereditary 1,25-dihydroxyvitamin D-resistant rickets. Endocr Rev. 1999;20(2):156–88.

    CAS  PubMed  Google Scholar 

  37. Vupperla D, Lunge SB, Elaprolu P. Vitamin D-dependent rickets type II with alopecia: a rare case report. Indian J Dermatol. 2018;63(2):176–9.

    PubMed  PubMed Central  Google Scholar 

  38. Aksu Cerman A, Sarikaya Solak S, Kivanc Altunay I. Vitamin D deficiency in alopecia areata. Br J Dermatol. 2014;170(6):1299–304.

    CAS  PubMed  Google Scholar 

  39. Mahamid M, Abu-Elhija O, Samamra M, Mahamid A, Nseir W. Association between vitamin D levels and alopecia areata. Isr Med Assoc J. 2014;16(6):367–70.

    PubMed  Google Scholar 

  40. Lee S, Kim BJ, Lee CH, Lee WS. Increased prevalence of vitamin D deficiency in patients with alopecia areata: a systematic review and meta-analysis. J Eur Acad Dermatol Venereol. 2018;32(7):1214–21.

    CAS  PubMed  Google Scholar 

  41. Gade VKV, Mony A, Munisamy M, Chandrashekar L, Rajappa M. An investigation of vitamin D status in alopecia areata. Clin Exp Med. 2018;18(4):577–84.

    CAS  PubMed  Google Scholar 

  42. Daroach M, Narang T, Saikia UN, Sachdeva N, Sendhil Kumaran M. Correlation of vitamin D and vitamin D receptor expression in patients with alopecia areata: a clinical paradigm. Int J Dermatol. 2018;57(2):217–22.

    CAS  PubMed  Google Scholar 

  43. Rasheed H, Mahgoub D, Hegazy R, El-Komy M, Abdel Hay R, Hamid MA, et al. Serum ferritin and vitamin d in female hair loss: do they play a role? Skin Pharmacol Physiol. 2013;26(2):101–7.

    CAS  PubMed  Google Scholar 

  44. Banihashemi M, Nahidi Y, Meibodi NT, Jarahi L, Dolatkhah M. Serum vitamin D3 level in patients with female pattern hair loss. Int J Trichology. 2016;8(3):116–20.

    PubMed  PubMed Central  Google Scholar 

  45. Moneib H, Fathy G, Ouda A. Possible association of female-pattern hair loss with alteration in serum 25-hydroxyvitamin D levels. Egypt J Dermatol Venerol. 2014;34:15–20.

    Google Scholar 

  46. Nayak K, Garg A, Mithra P, Manjrekar P. Serum vitamin D3 levels and diffuse hair fall among the student population in South India: a case-control study. Int J Trichology. 2016;8(4):160–4.

    PubMed  PubMed Central  Google Scholar 

  47. Karadag AS, Ertugrul DT, Tutal E, Akin KO. The role of anemia and Vitamin D levels in acute and chronic telogen effluvium. Turk J Med Sci. 2011;41:827–33.

    CAS  Google Scholar 

  48. Naziroglu M, Kokcam I. Antioxidants and lipid peroxidation status in the blood of patients with alopecia. Cell Biochem Funct. 2000;18(3):169–73.

    CAS  PubMed  Google Scholar 

  49. Trost LB, Bergfeld WF, Calogeras E. The diagnosis and treatment of iron deficiency and its potential relationship to hair loss. J Am Acad Dermatol. 2006;54(5):824–44.

    PubMed  Google Scholar 

  50. Shrivastava SB. Diffuse hair loss in an adult female: approach to diagnosis and management. Indian J Dermatol Venereol Leprol. 2009;75(1):20–7; quiz 7–8.

    PubMed  Google Scholar 

  51. Walters GO, Miller FM, Worwood M. Serum ferritin concentration and iron stores in normal subjects. J Clin Pathol. 1973;26(10):770–2.

    CAS  PubMed  PubMed Central  Google Scholar 

  52. Rushton DH. Nutritional factors and hair loss. Clin Exp Dermatol. 2002;27(5):396–404.

    CAS  PubMed  Google Scholar 

  53. Sinclair R. There is no clear association between low serum ferritin and chronic diffuse telogen hair loss. Br J Dermatol. 2002;147(5):982–4.

    CAS  PubMed  Google Scholar 

  54. Coenen JL, van Dieijen-Visser MP, van Pelt J, van Deursen CT, Fickers MM, van Wersch JW, et al. Measurements of serum ferritin used to predict concentrations of iron in bone marrow in anemia of chronic disease. Clin Chem. 1991;37(4):560–3.

    CAS  PubMed  Google Scholar 

  55. Rushton DH, Ramsay ID. The importance of adequate serum ferritin levels during oral cyproterone acetate and ethinyl oestradiol treatment of diffuse androgen-dependent alopecia in women. Clin Endocrinol. 1992;36(4):421–7.

    CAS  Google Scholar 

  56. Milman N, Kirchhoff M. Iron stores in 1359, 30- to 60-year-old Danish women: evaluation by serum ferritin and hemoglobin. Ann Hematol. 1992;64(1):22–7.

    CAS  PubMed  Google Scholar 

  57. Hallberg L, Bengtsson C, Lapidus L, Lindstedt G, Lundberg PA, Hulten L. Screening for iron deficiency: an analysis based on bone-marrow examinations and serum ferritin determinations in a population sample of women. Br J Haematol. 1993;85(4):787–98.

    CAS  PubMed  Google Scholar 

  58. Punnonen K, Irjala K, Rajamaki A. Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency. Blood. 1997;89(3):1052–7.

    CAS  PubMed  Google Scholar 

  59. Mast AE, Blinder MA, Gronowski AM, Chumley C, Scott MG. Clinical utility of the soluble transferrin receptor and comparison with serum ferritin in several populations. Clin Chem. 1998;44(1):45–51.

    CAS  PubMed  Google Scholar 

  60. Goldberg LJ, Lenzy Y. Nutrition and hair. Clin Dermatol. 2010;28(4):412–9.

    PubMed  Google Scholar 

  61. Vinton NE, Dahlstrom KA, Strobel CT, Ament ME. Macrocytosis and pseudoalbinism: manifestations of selenium deficiency. J Pediatr. 1987;111(5):711–7.

    CAS  PubMed  Google Scholar 

  62. Masumoto K, Nagata K, Higashi M, Nakatsuji T, Uesugi T, Takahashi Y, et al. Clinical features of selenium deficiency in infants receiving long-term nutritional support. Nutrition. 2007;23(11–12):782–7.

    CAS  PubMed  Google Scholar 

  63. Petru E, Petru C, Benedicic C. Re: “Selenium as an element in the treatment of ovarian cancer in women receiving chemotherapy”. Gynecol Oncol. 2005;96(2):559; author reply 559–60.

    CAS  PubMed  Google Scholar 

  64. Fan AM, Kizer KW. Selenium. Nutritional, toxicologic, and clinical aspects. West J Med. 1990;153(2):160–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  65. MacFarquhar JK, Broussard DL, Melstrom P, Hutchinson R, Wolkin A, Martin C, et al. Acute selenium toxicity associated with a dietary supplement. Arch Intern Med. 2010;170(3):256–61.

    PubMed  PubMed Central  Google Scholar 

  66. Abdel Fattah NS, Atef MM, Al-Qaradaghi SM. Evaluation of serum zinc level in patients with newly diagnosed and resistant alopecia areata. Int J Dermatol. 2016;55(1):24–9.

    CAS  PubMed  Google Scholar 

  67. Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D, and fluoride. The National Academies Collection: reports funded by National Institutes of Health. Washington, DC: National Academies Press; 1997.

    Google Scholar 

  68. Goskowicz M, Eichenfield LF. Cutaneous findings of nutritional deficiencies in children. Curr Opin Pediatr. 1993;5(4):441–5.

    CAS  PubMed  Google Scholar 

  69. Alhaj E, Alhaj N, Alhaj NE. Diffuse alopecia in a child due to dietary zinc deficiency. Skinmed. 2007;6(4):199–200.

    PubMed  Google Scholar 

  70. Almohanna HM, Ahmed AA, Tsatalis JP, Tosti A. The role of vitamins and minerals in hair loss: a review. Dermatol Ther (Heidelb). 2019;9(1):51–70.

    Google Scholar 

  71. Trueb RM. Pharmacologic interventions in aging hair. Clin Interv Aging. 2006;1(2):121–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  72. Fatemi Naieni F, Ebrahimi B, Vakilian HR, Shahmoradi Z. Serum iron, zinc, and copper concentration in premature graying of hair. Biol Trace Elem Res. 2012;146(1):30–4.

    CAS  PubMed  Google Scholar 

  73. Klepser TB, Klepser ME. Unsafe and potentially safe herbal therapies. Am J Health Syst Pharm. 1999;56(2):125–38; quiz 39–41.

    CAS  PubMed  Google Scholar 

  74. Prager N, Bickett K, French N, Marcovici G. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern Complement Med. 2002;8(2):143–52.

    PubMed  Google Scholar 

  75. Rossi A, Mari E, Scarno M, Garelli V, Maxia C, Scali E, et al. Comparitive effectiveness of finasteride vs Serenoa repens in male androgenetic alopecia: a two-year study. Int J Immunopathol Pharmacol. 2012;25(4):1167–73.

    CAS  PubMed  Google Scholar 

  76. Matsuda H, Yamazaki M, Asanuma Y, Kubo M. Promotion of hair growth by ginseng radix on cultured mouse vibrissal hair follicles. Phytother Res. 2003;17(7):797–800.

    CAS  PubMed  Google Scholar 

  77. Murata K, Noguchi K, Kondo M, Onishi M, Watanabe N, Okamura K, et al. Inhibitory activities of Puerariae Flos against testosterone 5alpha-reductase and its hair growth promotion activities. J Nat Med. 2012;66(1):158–65.

    CAS  PubMed  Google Scholar 

  78. Kumar N, Rungseevijitprapa W, Narkkhong NA, Suttajit M, Chaiyasut C. 5alpha-reductase inhibition and hair growth promotion of some Thai plants traditionally used for hair treatment. J Ethnopharmacol. 2012;139(3):765–71.

    PubMed  Google Scholar 

  79. Esfandiari A, Kelly AP. The effects of tea polyphenolic compounds on hair loss among rodents. J Natl Med Assoc. 2005;97(8):1165–9.

    PubMed  PubMed Central  Google Scholar 

  80. Shimizu K, Kondo R, Sakai K, Shoyama Y, Sato H, Ueno T. Steroid 5alpha-reductase inhibitory activity and hair regrowth effects of an extract from Boehmeria nipononivea. Biosci Biotechnol Biochem. 2000;64(4):875–7.

    CAS  PubMed  Google Scholar 

  81. Park WS, Lee CH, Lee BG, Chang IS. The extract of Thujae occidentalis semen inhibited 5alpha-reductase and androchronogenetic alopecia of B6CBAF1/j hybrid mouse. J Dermatol Sci. 2003;31(2):91–8.

    PubMed  Google Scholar 

  82. Murata K, Noguchi K, Kondo M, Onishi M, Watanabe N, Okamura K, et al. Promotion of hair growth by Rosmarinus officinalis leaf extract. Phytother Res. 2013;27(2):212–7.

    PubMed  Google Scholar 

  83. Wikramanayake TC, Villasante AC, Mauro LM, Perez CI, Schachner LA, Jimenez JJ. Prevention and treatment of alopecia areata with quercetin in the C3H/HeJ mouse model. Cell Stress Chaperones. 2012;17(2):267–74.

    CAS  PubMed  Google Scholar 

  84. Anbalangan K, Sadique J. Influence of an Indian medicine (Ashwagandha) on acute-phase reactants in inflammation. Indian J Exp Biol. 1981;19:245–9.

    Google Scholar 

  85. Bone K. Clinical applications of Ayurvedic and Chinese herbs. Warwick: Phytotherapy Press; 1996. p. 137–41.

    Google Scholar 

  86. Towatari K, Yoshida K, Mori N, Shimizu K, Kondo R, Sakai K. Polyphenols from the heartwood of Cercidiphyllum japonicum and their effects on proliferation of mouse hair epithelial cells. Planta Med. 2002;68(11):995–8.

    CAS  PubMed  Google Scholar 

  87. Kamimura A, Takahashi T. Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory study. Br J Dermatol. 2002;146(1):41–51.

    CAS  PubMed  Google Scholar 

  88. Kamimura A, Takahashi T, Watanabe Y. Investigation of topical application of procyanidin B-2 from apple to identify its potential use as a hair growing agent. Phytomedicine. 2000;7(6):529–36.

    CAS  PubMed  Google Scholar 

  89. Takahashi T, Kamimura A, Yokoo Y, Honda S, Watanabe Y. The first clinical trial of topical application of procyanidin B-2 to investigate its potential as a hair growing agent. Phytother Res. 2001;15(4):331–6.

    CAS  PubMed  Google Scholar 

  90. Tenore GC, Caruso D, Buonomo G, D’Avino M, Santamaria R, Irace C, et al. Annurca apple nutraceutical formulation enhances keratin expression in a human model of skin and promotes hair growth and tropism in a randomized clinical trial. J Med Food. 2018;21(1):90–103.

    CAS  PubMed  PubMed Central  Google Scholar 

  91. Shin HS, Lee JM, Park SY, Yang JE, Kim JH, Yi TH. Hair growth activity of Crataegus pinnatifida on C57BL/6 mouse model. Phytother Res. 2013;27(9):1352–7.

    PubMed  Google Scholar 

  92. Shao LX. [Effects of the extract from bergamot and boxthorn on the delay of skin aging and hair growth in mice]. Zhongguo Zhong Yao Za Zhi. 2003;28(8):766–9.

    Google Scholar 

  93. Dhanotia R, Chauhan NS, Saraf DK, Dixit VK. Effect of Citrullus colocynthis Schrad fruits on testosterone-induced alopecia. Nat Prod Res. 2011;25(15):1432–43.

    CAS  PubMed  Google Scholar 

  94. Roy RK, Thakur M, Dixit VK. Development and evaluation of polyherbal formulation for hair growth-promoting activity. J Cosmet Dermatol. 2007;6(2):108–12.

    PubMed  Google Scholar 

  95. Patel S, Sharma V, Chauhan NS, Dixit VK. An updated review on the parasitic herb of Cuscuta reflexa Roxb. Zhong Xi Yi Jie He Xue Bao. 2012;10(3):249–55.

    CAS  PubMed  Google Scholar 

  96. Hornfeldt CS. Growing evidence of the beneficial effects of a marine protein-based dietary supplement for treating hair loss. J Cosmet Dermatol. 2018;17(2):209–13.

    PubMed  Google Scholar 

  97. Hornfeldt CS, Holland M, Bucay VW, Roberts WE, Waldorf HA, Dayan SH. The safety and efficacy of a sustainable marine extract for the treatment of thinning hair: a summary of new clinical research and results from a panel discussion on the problem of thinning hair and current treatments. J Drugs Dermatol. 2015;14(9):s15–22.

    CAS  PubMed  Google Scholar 

  98. Colombo VE, Gerber F, Bronhofer M, Floersheim GL. Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy. J Am Acad Dermatol. 1990;23(6 Pt 1):1127–32.

    CAS  PubMed  Google Scholar 

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Almohanna, H.M., Ahmed, A.A., Tosti, A. (2020). Role of Oral Supplements: When and How to Choose. In: Tosti, A., Asz-Sigall, D., Pirmez, R. (eds) Hair and Scalp Treatments. Springer, Cham. https://doi.org/10.1007/978-3-030-21555-2_7

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