Abstract
Nutrition is considered one of the key behaviours that influence healthy ageing. Evidence on the impact of traditional Mediterranean diet (MD) on health and longevity has accumulated over the years. With a consistency unusual in biomedical research, adherence to MD has been associated with better survival and lower incidence and mortality from cardiovascular diseases and malignant neoplasms. These associations were evident among diverse populations, at different points in time and by different investigators, using both observational and experimental study designs, thus strengthening the likelihood of a possible causal association. Higher adherence to MD has also been associated with reduced incidence of type 2 diabetes, dementia and hip fractures, all of which have considerable burden among older adults. Beyond primary prevention, MD seems to possess a therapeutic and favourable prognostic role among patients with cardiovascular diseases, diabetes, rheumatoid arthritis, osteoarthritis and cancer. Last but not least, MD is an excellent example of a sustainable diet, in which nutrition, local food production, food safety, culture, biodiversity and sustainability are strongly interconnected.
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References
World report on ageing and health. Geneva: World Health Organization; 2015.
Global strategy and action plan on ageing and health. Geneva: World Health Organization; 2017. Licence: CC BY-NC-SA3.0 IGO.
World Cancer Research Fund/American Institute for Cancer Research: Diet, Nutrition and Physical Activity: a Global Perspective. Continuous Update Project Expert Report; 2018. dietandcancerreport.org.
Schulze MB, Martínez-González MA, Fung TT, Lichtenstein AH, Forouhi NG. Food based dietary patterns and chronic disease prevention. BMJ. 2018;13(361):k2396.
Bamia C. Dietary patterns in association to cancer incidence and survival: concept, current evidence, and suggestions for future research. Eur J Clin Nutr. 2018;72(6):818–25.
Hu FB. Dietary pattern analysis: a new direction in nutritional epidemiology. Curr Opin Lipidol. 2002;13:3–9.
Millen BE, Abrams S, Adams-Campbell L, Anderson CA, Brenna JT, Campbell WW, et al. The 2015 dietary guidelines advisory committee scientific report: development and major conclusions. Adv Nutr. 2016;7(3):438–44.
Tapsell LC, Neale EP, Satija A, Hu FB. Foods, nutrients, and dietary patterns: interconnections and implications for dietary guidelines. Adv Nutr. 2016;7(3):445–54.
Jankovic N, Geelen A, Streppel MT, de Groot LC, Orfanos P, van den Hooven EH, et al. Adherence to a healthy diet according to the World Health Organization guidelines and all-cause mortality in elderly adults from Europe and the United States. Am J Epidemiol. 2014;180(10):978–88.
Jankovic N, Geelen A, Winkels RM, Mwungura B, Fedirko V, Jenab M, et al. Consortium on health and ageing: network of cohorts in Europe and the United States (CHANCES). Adherence to the WCRF/AICR dietary recommendations for cancer prevention and risk of cancer in elderly from Europe and the United States: a meta-analysis within the CHANCES project. Cancer Epidemiol Biomarkers Prev. 2017;26(1):136–44.
Trichopoulou A, Lagiou P. Healthy traditional Mediterranean diet: an expression of culture, history and lifestyle. Nutr Rev. 1997;55:383–9.
Keys A. Seven countries. A multivariate analysis of death and coronary heart disease. Cambridge: Harvard University Press: London; 1980.
Trichopoulou A, Costacou T, Bamia C, Trichopoulos D. Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med. 2003;348:2599–608.
Bach-Faig A, Serra-Majem L, Carrasco JL, Roman B, Ngo J, Bertomeu I, et al. The use of indexes evaluating the adherence to the Mediterranean diet in epidemiological studies: a review. Public Health Nutr. 2006;9(1A):132–46.
Sofi F, Macchi C, Abbate R, Gensini GF, Casini A. Mediterranean diet and health status: an updated meta-analysis and a proposal for a literature-based adherence score. Public Health Nutr. 2014;17(12):2769–82.
Benetou V, Orfanos P, Feskanich D, Michaëlsson K, Pettersson-Kymmer U, Byberg L, et al. Mediterranean diet and hip fracture incidence among older adults: the CHANCES project. Osteoporos Int. 2018;29(7):1591–9.
Dinu M, Pagliai G, Casini A, et al. Mediterranean diet and multiple health outcomes: an umbrella review of meta-analyses of observational studies and randomised trials. Eur J Clin Nutr. 2018;72(1):30–43.
Eleftheriou D, Benetou V, Trichopoulou A, La Vecchia C, Bamia C. Mediterranean diet and its components in relation to all-cause mortality: meta-analysis. Br J Nutr. 2018;120(10):1081–97.
Martinez-Gonzalez MA, Bes-Rastrollo M. Dietary patterns, Mediterranean diet, and cardiovascular disease. Curr Opin Lipidol. 2014;25:20–6.
Schwingshackl L, Hoffmann G. Mediterranean dietary pattern, inflammation and endothelial function: a systematic review and meta-analysis of intervention trials. Nutr Metab Cardiovasc Dis. 2014;24:929–39.
Gay HC, Rao SG, Vaccarino V, et al. Effects of different dietary interventions on blood pressure: systematic review and meta-analysis of randomized controlled trials. Hypertension. 2016;67:733–9.
Ahmad S, Moorthy MV, Demler OV, et al. Assessment of risk factors and biomarkers associated with risk of cardiovascular disease among women consuming a Mediterranean diet. JAMA Netw Open. 2018;1(8):e185708.
Estruch R, Ros E, Salas-Salvadó J, Covas MI, Corella D, Arós F, et al.; PREDIMED Study Investigators. Primary prevention of cardiovascular disease with a Mediterranean diet supplemented with extra-virgin olive oil or nuts. N Engl J Med. 2018;378(25):e34.
Couto E, Boffetta P, Lagiou P, Ferrari P, Buckland G, Overvad K, et al. Mediterranean dietary pattern and cancer risk in the EPIC cohort. Br J Cancer. 2011;104(9):1493–9.
Schwingshackl L, Missbach B, König J, Hoffmann G. Adherence to a Mediterranean diet and risk of diabetes: a systematic review and meta-analysis. Public Health Nutr. 2015;18(7):1292–9.
van de Rest O, Berendsen AA, Haveman-Nies A, de Groot LC. Dietary patterns, cognitive decline, and dementia: a systematic review. Adv Nutr. 2015;6(2):154–68.
Valls-Pedret C, Sala-Vila A, Serra-Mir M, Corella D, de la Torre R, Martínez-González MÁ, et al. Mediterranean diet and age-related cognitive decline: a randomized clinical trial. JAMA Intern Med. 2015;175(7):1094–103.
Trichopoulou A, Bamia C, Trichopoulos D. Anatomy of health effects of Mediterranean diet: Greek EPIC prospective cohort study. BMJ. 2009;23(338):b2337.
Diet, physical activity and cardiovascular disease prevention in Europe. European Heart Network; 2011.
Sköldstam L, Hagfors L, Johansson G. An experimental study of a Mediterranean diet intervention for patients with rheumatoid arthritis. Ann Rheum Dis. 2003;62(3):208–14.
Veronese N, Stubbs B, Noale M, Solmi M, Luchini C, Maggi S. Adherence to the Mediterranean diet is associated with better quality of life: data from the osteoarthritis initiative. Am J Clin Nutr. 2016;104(5):1403–9.
Dyer J, Davison G, Marcora SM, Mauger AR. Effect of a Mediterranean type diet on inflammatory and cartilage degradation biomarkers in patients with osteoarthritis. J Nutr Health Aging. 2017;21(5):562–6.
Trichopoulou A, Bamia C, Trichopoulos D. Mediterranean diet and survival among patients with coronary heart disease in Greece. Arch Intern Med. 2005;165(8):929–35.
de Lorgeril M, Salen P, Martin JL, Monjaud I, Delaye J, Mamelle N. Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. Circulation. 1999;99(6):779–85.
Frölich S, Lehmann N, Weyers S, Wahl S, Dragano N, Budde T, Kälsch H, et al.; Heinz Nixdorf Recall Study Investigators. Association of dietary patterns with five-year degree and progression of coronary artery calcification in the Heinz Nixdorf Recall Study. Nutr Metab Cardiovasc Dis. 2017;27(11):999–1007.
Esposito K, Maiorino MI, Ceriello A, Giugliano D. Prevention and control of type 2 diabetes by Mediterranean diet: a systematic review. Diabetes Res Clin Pract. 2010;89(2):97–102.
Ratjen I, Schafmayer C, di Giuseppe R, Waniek S, Plachta-Danielzik S, Koch M, Nöthlings U, Hampe J, Schlesinger S, Lieb W. Postdiagnostic Mediterranean and healthy Nordic dietary patterns are inversely associated with all-cause mortality in long-term colorectal cancer survivors. J Nutr. 2017;147(4):636–44.
Trichopoulou A. Diversity v. globalization: traditional foods at the epicentre. Public Health Nutr. 2012;15(6):951–4.
Burlingame B, Dernini S. Sustainable diets: the Mediterranean diet an example. Public Health Nutr. 2011;14(12A):2285–7.
Martínez-González MÁ, Hershey MS, Zazpe I, Trichopoulou A. Correction: Martínez-González, M.A. et al. Transferability of the Mediterranean diet to non-Mediterranean countries. What is and what is not the Mediterranean diet. Nutrients 2017, 9, 1226. Nutrients. 2018;10(7).
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Dedicated to our dear friend and colleague Christina Bamia
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Trichopoulou, A., Benetou, V. (2019). Impact of Mediterranean Diet on Longevity. In: Caruso, C. (eds) Centenarians. Springer, Cham. https://doi.org/10.1007/978-3-030-20762-5_10
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DOI: https://doi.org/10.1007/978-3-030-20762-5_10
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